Gold Nanoparticle Imaging and Radiotherapy of Brain Tumors in Mice

Hainfeld, James F.; Smilowitz, Henry M.; O’Connor, Michael J.; Dilmanian, F.A.; Slatkin, Daniel N.

doi:10.2217/nnm.12.165

Cited by 363 publications

(259 citation statements)

References 37 publications

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“…Electron-dense materials such as gold were proven to be suited for this purpose in a series of in vitro and in vivo studies [e.g., (10)(11)(12)(13)(14)(15)]. It is important to point out here that gold NP do not per se alter the cellular radiosensitivity of a tumour.…”

Section: Gold Np As a Microenvironmental Radiation Boostermentioning

confidence: 99%

Targeted nanoparticles for tumour radiotherapy enhancement—the long dawn of a golden era?

Gargioni¹,

Schulz²,

Raabe³

et al. 2016

Ann. Transl. Med.

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Despite considerable progress in (I) our understanding of the aetiopathology of head and neck cancer and (II) the precise delivery of radiotherapy, long-term survival rates for many patients with head and neck cancer remain disappointingly low. Over the past years, gold nanoparticles (NP) have emerged as promising radiation dose enhancers. In a recent study published in Nanoscale, Popovtzer et al. have used gold NP coated with an antibody against the epidermal growth factor receptor (EGFR) in an attempt to enhance radiation-induced tumour cell killing in a head and neck cancer xenograft model. They report a significant impact of the combined treatment with radiation and gold NP on tumour growth and suggest an involvement of apoptosis, inhibition of angiogenesis and diminished tissue repair. In this perspective, we illustrate the underlying radiobiophysical concepts and discuss some of the challenges associated with this and related nanoparticle-radiotherapy studies from a physics, chemistry, biology and therapy angle. We conclude that strong interdisciplinary collaborations spanning all these areas are crucially important to proceed towards effective cancer treatment with gold NP "from bench to bedside".

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Section: Gold Np As a Microenvironmental Radiation Boostermentioning

confidence: 99%

Targeted nanoparticles for tumour radiotherapy enhancement—the long dawn of a golden era?

Gargioni¹,

Schulz²,

Raabe³

et al. 2016

Ann. Transl. Med.

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“…Page 2 Q3 Author: Please check whether the citation of 'Chen et al (2013)' is correct here or you intended to cite 'Hainfeld et al (2012)' instead.…”

Section: Q1mentioning

confidence: 99%

“…Page 15 Q8 Author: Please check whether the volume number and page range is okay as included in reference 'Hainfeld et al (2012)'.…”

Section: Q1mentioning

confidence: 99%

An x-ray fluorescence imaging system for gold nanoparticle detection

et al. 2013

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Gold nanoparticles (GNPs) may be used as a contrast agent to identifytumour location and can be modified to target-and image-specific tumour biological parameters. There are currently no imaging systems in the literature that have sufficient sensitivity to GNP concentration and distribution measurement at sufficient tissue depth for use in in vivo and in vitro studies. We have demonstrated that high detecting sensitivity of GNPs can be achieved using x-ray fluorescence; furthermore this technique enables higher depth imaging in comparison to optical modalities. Two x-ray fluorescence systems were developed and used to image a range of GNP imaging phantoms. The first system consisted of a 10 mm 2 silicon drift detector coupled to a slightly focusing polycapillary optic which allowed 2D energy resolved imaging in step and scan mode. The system has sensitivity to GNP concentrations as low as 1 ppm. GNP concentrations different by a factor of 5 could be resolved, offering potential to distinguish tumour from non-tumour. The second system was designed to avoid slow step and scan image acquisition; the feasibility of excitation of the whole specimen with a wide beam and detection of the fluorescent x-rays with a pixellated controlled drift energy resolving detector without scanning was investigated. A parallel polycapillary optic coupled to the detector was successfully used to ascertain the position where fluorescence was emitted. The tissue penetration of the technique was demonstrated to be sufficient for nearsurface small-animal studies, and for imaging 3D in vitro cellular constructs. Previous work demonstrates strong potential for both imaging systems to form quantitative images of GNP concentration.

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“…Recently, the modification of GNPs with polyethylene glycol (PEG)-binding (PEGylation) has been reported to achieve a favorable treatment effect (15)(16)(17)(18). As a foreign body, GNPs are rapidly incorporated and removed by the reticuloendothelial system; PEGylation inhibits this reaction (18) and may lead to a tumor-specific treatment effect.…”

Section: Introductionmentioning

confidence: 99%

Optimal method of gold nanoparticle administration in melanoma‑bearing mice

et al. 2018

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Abstract. The present study assessed different methods of administering gold nanoparticles (GNPs) using different formulations to determine which of the methods achieved optimal radiosensitization. Cells from the B16F10 mouse melanoma cell line were implanted in the femoral area of mice, assigned to one of the eight following groups: i) Control; ii) intravenous (IV) injection of polyethylene glycol (PEG)-binding GNPs (Peg-GNPs) alone; iii) direct intratumoral (IT) injection of Peg-GNPs alone; iv) radiotherapy (RT)-alone; v) Peg-GNP IV + RT; vi) Peg-GNP IT + RT; vii) naked GNP (N-GNPs) IV + RT; and viii) N-GNP IT + RT. Injection volumes of the Peg-GNPs (particle size, 15 nm; dose, 2.8 mg/ml) and N-GNPs (particle size, 15 nm; dose, 200 mg Au/cc) were 0.3 and 0.2 ml per mouse, respectively, for IV and IT. The femoral area was irradiated with a single dose of 10 Gy. To evaluate the effects of GNPs, the current study measured the changes in the tumor volume ratio to the initial tumor volume over time and observed the survival rate. Administration of GNPs with RT did not improve the suppression of tumor growth or survival to a statistically significant extent. The administration of Peg-GNPs alone indicated a slight tumor suppressing effect at the early stage. The current study was not able to confirm the radiosensitization effect of GNPs in melanoma-bearing mice with tumors that were large in comparison to previous studies. Further research is required to validate the radiosensitizing effect on large tumors.

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Gold Nanoparticle Imaging and Radiotherapy of Brain Tumors in Mice

Cited by 363 publications

References 37 publications

Targeted nanoparticles for tumour radiotherapy enhancement—the long dawn of a golden era?

Targeted nanoparticles for tumour radiotherapy enhancement—the long dawn of a golden era?

An x-ray fluorescence imaging system for gold nanoparticle detection

Optimal method of gold nanoparticle administration in melanoma‑bearing mice

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