Gold nanoparticle-enhanced target (AuNPET) as universal solution for laser desorption/ionization mass spectrometry analysis and imaging of low molecular weight compounds

Sekuła, Justyna; Nizioł, Joanna; Rode, Wojciech; Ruman, Tomasz

doi:10.1016/j.aca.2015.01.046

Cited by 90 publications

(75 citation statements)

References 60 publications

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“…ions (AuNPET plate Fig. 7 IR spectrum of anhydrous oligoetherol [15]) as well as by-products-glycols (PG, DPG and TPG), one can observe molecular peaks different from each other by m/z units = 58 (in Table 3, e.g. sn.…”

Section: Resultsmentioning

confidence: 99%

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Oligoetherols based on melamine–formaldehyde–butanone resins

Głowacz-Czerwonka

2016

Polym. Bull.

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New oligoetherols with 1,3,5-triazine ring were obtained from melamineformaldehyde-butanone resins using 12 molar excess propylene oxide (with respect to the amount of introduced melamine). The resins were obtained from melamine solutions in reactive solvent obtained from simple chemical compound-methyl ethyl ketone (butan-2-one) in its reaction with 3 molar excess formaldehyde. Physical and chemical properties of obtained oligoetherols were determined and their structure was confirmed on the basis of proton magnetic resonance, infrared spectral data and MALDI-ToF mass analysis. The amount of by-products was specified on the basis of chromatographic analysis. Initial tests proved that obtained oligoetherols can constitute a potential substrate for obtaining polyurethane foams of increased thermal resistance.

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Section: Resultsmentioning

confidence: 99%

“…Sample solutions (ca. 5 mg/ml in CH 3 OH) were placed on AuNPET [15] (0.5 lL) with 0.5 lL standard DHB solution. Sum of ca.…”

Section: Spectral Analysismentioning

confidence: 99%

Oligoetherols based on melamine–formaldehyde–butanone resins

Głowacz-Czerwonka

2016

Polym. Bull.

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“…Peaks of all expected adducts of 5 were registered in the mass spectrum recorded according to the surface-assisted laser desorption/ionization (SALDI) technique [42] …”

Section: Mass Spectrummentioning

confidence: 99%

Synthesis, structural characterization and thermal studies of a novel reagent 1-[(5-benzyl-1,3-thiazol-2-yl)diazenyl]naphthalene-2-ol

Tupys

Kalembkiewicz

Ostapiuk

et al. 2016

J Therm Anal Calorim

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A new thiazolylazo reagent 1-[(5-benzyl-1,3-thiazol-2-yl)diazenyl]naphthalene-2-ol has been synthesized via arylation of acrolein and further diazotization and diazocoupling with 2-naphthol. The chemical structure of the compound was confirmed by IR, NMR: 1 H, 13 C, COSY, HSQC and SALDI-MS spectral data. The DSC method was employed to determine the melting point and the enthalpy of fusion (T fus = 159.7°C and DH fus = 28.0 kJ mol -1 , respectively). Thermal stability and decomposition studies of the obtained azo dye were performed in air and nitrogen atmosphere using the TG technique. The evolved gases from the heated sample were registered on FTIR spectra. The decomposition of the azo dye in air atmosphere occurred in five consecutive stages. The pK a ionization constants of the substance were determined in ethanol-water mixture (1:1 v/v) by means of the spectroscopic method and were found to be equal to 0.41 for pK a1 and 9.59 for pK a2 . Using the spectrophotometric procedures, the methods for determination of trace amounts of toxic metallic ions with the new reagent were characterized and limits of detection were calculated.

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“…In fact, both metal-and carbon-based nanoparticles have been evaluated [12][13][14][15]. For example, gold nanoparticles were recently shown to enhance the analysis of small organic compounds with diverse polarity, such as amino acids, saccharides, nucleosides, and nucleic bases [16]. However, enrichment of sodium was intentionally applied so that sodiated adducts are formed to facilitate the MALDI-MS analysis [16].…”

Section: Introductionmentioning

confidence: 99%

“…For example, gold nanoparticles were recently shown to enhance the analysis of small organic compounds with diverse polarity, such as amino acids, saccharides, nucleosides, and nucleic bases [16]. However, enrichment of sodium was intentionally applied so that sodiated adducts are formed to facilitate the MALDI-MS analysis [16]. Gold nanoparticles were also surface-modified with α-cyano-4-hydroxycinnamic acid (CHCA) conventional matrix for the effective analysis of protein digests [17].…”

Section: Introductionmentioning

confidence: 99%

The Development of Novel Nanodiamond Based MALDI Matrices for the Analysis of Small Organic Pharmaceuticals

Chitanda

Zhang

Pahl

et al. 2016

J. Am. Soc. Mass Spectrom.

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Abstract. The utility of novel functionalized nanodiamonds (NDs) as matrices for matrix-assisted laser desorption ionization-mass spectrometry (MALDI-MS) is described herein. MALDI-MS analysis of small organic compounds (<1000 Da) is typically complex because of interferences from numerous cluster ions formed when using conventional matrices. To expand the use of MALDI for the analysis of small molecules, novel matrices were designed by covalently linking conventional matrices (or a lysine moiety) to detonated NDs. Four new functionalized NDs were evaluated for their ionization capabilities using five pharmaceuticals with varying molecular structures. Two ND matrices were able to ionize all tested pharmaceuticals in the negative ion mode, producing the deprotonated ions [M -H] -. Ion intensity for target analytes was generally strong with enhanced signal-to-noise ratios compared with conventional matrices. The negative ion mode is of great importance for biological samples as interference from endogenous compounds is inherently minimized in the negative ion mode. Since the molecular structures of the tested pharmaceuticals did not suggest that negative ion mode would be preferable, this result magnifies the importance of these findings. On the other hand, conventional matrices primarily facilitated the ionization as expected in the positive ion mode, producing either the protonated molecules [M + H] + or cationic adducts (typically producing complex spectra with numerous adduct peaks). The data presented in this study suggests that these matrices may offer advantages for the analysis of low molecular weight pharmaceuticals/metabolites.

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Gold nanoparticle-enhanced target (AuNPET) as universal solution for laser desorption/ionization mass spectrometry analysis and imaging of low molecular weight compounds

Cited by 90 publications

References 60 publications

Oligoetherols based on melamine–formaldehyde–butanone resins

Oligoetherols based on melamine–formaldehyde–butanone resins

Synthesis, structural characterization and thermal studies of a novel reagent 1-[(5-benzyl-1,3-thiazol-2-yl)diazenyl]naphthalene-2-ol

The Development of Novel Nanodiamond Based MALDI Matrices for the Analysis of Small Organic Pharmaceuticals

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