Gold nanoparticle-directed autophagy intervention for antitumor immunotherapy via inhibiting tumor-associated macrophage M2 polarization

Zhang, Siyue; Xie, Fang; Li, Kaichun; Zhang, He; Yin, You; Yuan, Yu; Lu, Guangzhao; Zhang, Shihao; Yan, Wei; Xu, Ke; Wu, Yan; Jin, Hong; Xiao, Lan; Bao, Leilei; Xu, Can; Li, Yulin; Lü, Ying; Gao, Jie

doi:10.1016/j.apsb.2022.02.008

Cited by 47 publications

(33 citation statements)

References 59 publications

(83 reference statements)

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“…In this study, nanoparticles suppressed TAMs M2 polarization via induction of lysosome dysfunction and autophagic flux inhibition in both in vitro and in vivo models. 63 In another study, gene shifts in TAMs towards M1 type and also induced apoptosis in cancer associated fibroblasts were observed upon treating with a biodegradable nanoparticle called ONP-302 during in vivo analysis. These particles are negatively charged and were developed from poly(lactic- co -glycolic acid) (PLGA).…”

Section: Mechanism Of Targeting By Nano Drug Vehiclesmentioning

confidence: 98%

Cancer nanomedicine: a review of nano-therapeutics and challenges ahead

et al. 2023

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Section: Mechanism Of Targeting By Nano Drug Vehiclesmentioning

confidence: 98%

Cancer nanomedicine: a review of nano-therapeutics and challenges ahead

et al. 2023

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“…In addition to IL-4 and IL-13, cytokines such as IL-10 can also regulate M2 macrophage polarization by activating STAT3 through IL-10R [ 16 ]. M2 macrophages are characterized by the secretion of anti-inflammatory cytokines, namely the low expression of IL-12 and high production of IL-10 and transforming growth factor-β (TGF-β) [ 17 , 18 ]. The main function of M2 macrophages is the trophic effect on tissues, while their weak antigen-presenting ability inhibits inflammatory responses and promotes wound healing, angiogenesis and tissue repair [ 14 , 19 ].…”

Section: Introductionmentioning

confidence: 99%

Targeting macrophages: a novel treatment strategy in solid tumors

Liu

Song

et al. 2022

J Transl Med

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In the tumor microenvironment (TME), tumor-associated macrophages (TAMs) are the most abundant immune cells, which act as a key regulator in tumorigenesis and progression. Increasing evidence have demonstrated that the TME alters the nature of macrophages to maintain dynamic tissue homeostasis, allowing TAMs to acquire the ability to stimulate angiogenesis, promote tumor metastasis and recurrence, and suppress anti-tumor immune responses. Furthermore, tumors with high TAM infiltration have poor prognoses and are resistant to treatment. In the field of solid tumor, the exploration of tumor-promoting mechanisms of TAMs has attracted much attention and targeting TAMs has emerged as a promising immunotherapeutic strategy. Currently, the most common therapeutic options for targeting TAMs are as follows: the deletion of TAMs, the inhibition of TAMs recruitment, the release of phagocytosis by TAMs, and the reprogramming of macrophages to remodel their anti-tumor capacity. Promisingly, the study of chimeric antigen receptor macrophages (CAR-Ms) may provide even greater benefit for patients with solid tumors. In this review, we discuss how TAMs promote the progression of solid tumors as well as summarize emerging immunotherapeutic strategies that targeting macrophages.

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“…Preparation and Characterization of MSC-NVs-Western Blotting (WB): WB analysis of CD-9, CD-63, 𝛽-actin, GAPDH, collagen II, MMP13, and Aggrecan was carried out according to the standard methods provided by Cell Signaling Technology, as described previously. [54] More detailed procedures can be found in Materials and Methods (Supporting Information).…”

Section: Preparation and Characterization Of Msc-nvs-transmission Ele...mentioning

confidence: 99%

Treatment with Mesenchymal Stem Cell‐Derived Nanovesicle‐Containing Gelatin Methacryloyl Hydrogels Alleviates Osteoarthritis by Modulating Chondrogenesis and Macrophage Polarization

Pang

Jin

et al. 2023

Adv Healthcare Materials

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Osteoarthritis is a degenerative disorder that can severely affect joints, and new treatment strategies are urgently needed. Administration of mesenchymal stem cell (MSC)‐derived exosomes is a promising therapeutic strategy in osteoarthritis treatment. However, the poor yield of exosomes is an obstacle to the use of this modality in the clinic. Herein, a promising strategy is developed to fabricate high‐yield exosome‐mimicking MSC‐derived nanovesicles (MSC‐NVs) with enhanced regenerative and anti‐inflammatory capabilities. MSC‐NVs are prepared using an extrusion approach and are found to increase chondrocyte and human bone marrow MSC differentiation, proliferation, and migration, in addition to inducing M2 macrophage polarization. Furthermore, gelatin methacryloyl (GelMA) hydrogels loaded with MSC‐NVs (GelMA‐NVs) are formulated, which exhibit sustained release of MSC‐NVs and are shown to be biocompatible with excellent mechanical properties. In a mouse osteoarthritis model constructed by surgical destabilization of the medial meniscus (DMM), GelMA‐NVs effectively ameliorate osteoarthritis severity, reduce the secretion of catabolic factors, and enhance matrix synthesis. Furthermore, GelMA‐NVs induce M2 macrophage polarization and inflammatory response inhibition in vivo. The findings demonstrate that GelMA‐NVs hold promise for osteoarthritis treatment through modulation of chondrogenesis and macrophage polarization.

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Gold nanoparticle-directed autophagy intervention for antitumor immunotherapy via inhibiting tumor-associated macrophage M2 polarization

Cited by 47 publications

References 59 publications

Cancer nanomedicine: a review of nano-therapeutics and challenges ahead

Cancer nanomedicine: a review of nano-therapeutics and challenges ahead

Targeting macrophages: a novel treatment strategy in solid tumors

Treatment with Mesenchymal Stem Cell‐Derived Nanovesicle‐Containing Gelatin Methacryloyl Hydrogels Alleviates Osteoarthritis by Modulating Chondrogenesis and Macrophage Polarization

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