Gold nanoparticle-carbon nanotube multilayers on silica microspheres: Optoacoustic-Raman enhancement and potential biomedical applications

Nozdriukhin, Daniil; Besedina, Nadezhda A.; Chernyshev, Vasiliy S.; Efimova, Olga; Rudakovskaya, Polina G.; Новоселова, М. В.; Bratashov, Daniil N.; Chuprov‐Netochin, Roman N.; Kamyshinsky, Roman; Vasiliev, Alexander L.; Chermoshentsev, Dmitry A.; Dyakov, Sergey A.; Zharov, Vladimir P.; Gippius, N. A.; Gorin, Dmitry A.; Yashchenok, Alexey M.

doi:10.1016/j.msec.2020.111736

Cited by 17 publications

(13 citation statements)

References 35 publications

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“…Owing to the absence of intrinsic contrast inside the lymph nodes, exogenous contrast agents are used for photoacoustic detection. The development of contrast agents for photoacoustic applications has been the subject of much research [84][85][86][87][88][89]. Noninvasive mapping of SLNs by photoacoustic imaging has involved the use of various contrast agents, including methylene blue, single-walled carbon nanotubes and gold nanospheres, nanocages and nanorods [90][91][92][93][94].…”

Section: Photoacoustic Imagingmentioning

confidence: 99%

Sentinel lymph node detection by combining nonradioactive techniques with contrast agents: State of the art and prospects

Kurochkin

German

Abalymov

et al. 2021

Journal of Biophotonics

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The status of sentinel lymph nodes (SLNs) has a substantial prognostic value because these nodes are the first place where cancer cells accumulate along their spreading route. Routine SLN biopsy ("gold standard") involves peritumoral injections of radiopharmaceuticals, such as technetium-99m, which has obvious disadvantages. This review examines the methods used as "gold standard" analogs to diagnose SLNs. Nonradioactive preoperative and intraoperative methods of SLN detection are analyzed. Promising photonic tools for SLNs detection are reviewed, including NIR-I/NIR-II fluorescence imaging, photoswitching dyes for SLN detection, in vivo photoacoustic detection, imaging and biopsy of SLNs. Also are discussed methods of SLN detection by magnetic resonance imaging, ultrasonic imaging systems including as combined with photoacoustic imaging, and methods based on the magnetometer-aided detection of superparamagnetic nanoparticles. The advantages and disadvantages of nonradioactive SLN-detection methods are shown. The review concludes with prospects for the use of conservative diagnostic methods in combination with photonic tools.

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Section: Photoacoustic Imagingmentioning

confidence: 99%

Sentinel lymph node detection by combining nonradioactive techniques with contrast agents: State of the art and prospects

Kurochkin

German

Abalymov

et al. 2021

Journal of Biophotonics

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“…The double MWCNT/AuNP layered structure aimed at increasing light absorbance in the NIR spectral region (from 680 to 850 nm) as recently demonstrated. 31 Layers of carbon nanotubes provide increased roughness of the surface of the particle in comparison to the smooth surface of silica. This increases the amount of absorbed gold nanoparticles, which in turn increases the OA amplitude.…”

Section: ■ Resultsmentioning

confidence: 99%

“…72 Integrating various nanomaterials such as fluorescent dyes, plasmonic nanoparticles, carbon nanotubes, and others in one particle allows multimodal imaging, sensing, and treatment. 31,73 Such multimodal particles may also be used to enhance the OA imaging performance. 74,75 ■ CONCLUSION…”

Section: ■ Discussionmentioning

confidence: 99%

“…Core–shell microparticles providing OA contrast were produced utilizing a layer-by-layer approachsequential deposition of opposite-charged building blocks (low molecular weight and polymer molecules, inorganic nanoparticles) from an aqueous solution (Figure a). − All polyelectrolytes were dissolved at a concentration 2 mg/mL in 0.15 M NaCl solution. A 200 μL silica microsphere suspension was diluted 10 times and rinsed with double-deionized water.…”

Section: Methodsmentioning

confidence: 99%

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Rapid Volumetric Optoacoustic Tracking of Individual Microparticles In Vivo Enabled by a NIR-Absorbing Gold–Carbon Shell

Nozdriukhin

Kalva

et al. 2021

ACS Appl. Mater. Interfaces

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Rapid volumetric in vivo visualization of circulating microparticles can facilitate new biomedical applications, such as blood flow characterization or targeted drug delivery. However, existing imaging modalities generally lack the sensitivity to detect the weak signals generated by individual micrometer-sized particles distributed across millimeter-to centimeter-scale depths in living mammalian tissues. Also, the temporal resolution is typically insufficient to track the particles in an entire three-dimensional region. Herein, we introduce a new type of monodisperse (4 μm) silica-core microparticle coated with a shell formed by a multilayered structure of carbon nanotubes (CNT) and gold nanoparticles (AuNP) to provide strong optoacoustic (OA) absorption-based contrast. We capitalize on the unique advantages of a state-of-the-art high-frame-rate OA tomography system to visualize and track the motion of these core−shell particles individually and volumetrically as they flow throughout the mouse brain vasculature. The feasibility of localizing individual solid particles smaller than red blood cells opens new opportunities for mapping the blood flow velocity, enhancing the resolution and visibility of OA images, and developing new biosensing assays.

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“…Nozdriukhin et al developed a AuNP–CNT multilayer on silica microspheres for a PA-Raman enhanced probe [ 155 ]. The PA-Raman bimodal contrast agents were fabricated by the layer-by-later self-assembly method of CNT and AuNPs around the silica–PDDA/PSS/PDDA microsphere ((PDDA/PSS/PDDA–silica)/CNT/AuNP).…”

Section: Carbon-nanotube-based Photoacoustic Imagingmentioning

confidence: 99%

State of the Art in Carbon Nanomaterials for Photoacoustic Imaging

et al. 2022

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Photoacoustic imaging using energy conversion from light to ultrasound waves has been developed as a powerful tool to investigate in vivo phenomena due to their complex characteristics. In photoacoustic imaging, endogenous chromophores such as oxygenated hemoglobin, deoxygenated hemoglobin, melanin, and lipid provide useful biomedical information at the molecular level. However, these intrinsic absorbers show strong absorbance only in visible or infrared optical windows and have limited light transmission, making them difficult to apply for clinical translation. Therefore, the development of novel exogenous contrast agents capable of increasing imaging depth while ensuring strong light absorption is required. We report here the application of carbon nanomaterials that exhibit unique physical, mechanical, and electrochemical properties as imaging probes in photoacoustic imaging. Classified into specific structures, carbon nanomaterials are synthesized with different substances according to the imaging purposes to modulate the absorption spectra and highly enhance photoacoustic signals. In addition, functional drugs can be loaded into the carbon nanomaterials composite, and effective in vivo monitoring and photothermal therapy can be performed with cell-specific targeting. Diverse applied cases suggest the high potential of carbon nanomaterial-based photoacoustic imaging in in vivo monitoring for clinical research.

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Gold nanoparticle-carbon nanotube multilayers on silica microspheres: Optoacoustic-Raman enhancement and potential biomedical applications

Cited by 17 publications

References 35 publications

Sentinel lymph node detection by combining nonradioactive techniques with contrast agents: State of the art and prospects

Sentinel lymph node detection by combining nonradioactive techniques with contrast agents: State of the art and prospects

Rapid Volumetric Optoacoustic Tracking of Individual Microparticles In Vivo Enabled by a NIR-Absorbing Gold–Carbon Shell

State of the Art in Carbon Nanomaterials for Photoacoustic Imaging

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