Gold nanoparticle-assisted enhancement in the anti-cancer properties of theaflavin against human ovarian cancer cells

Maity, Ritwik; Chatterjee, Manosree; Banerjee, Anmol; Das, Amlan; Mishra, Raghwendra; Mazumder, Sonal; Chanda, Nripen

doi:10.1016/j.msec.2019.109909

Cited by 29 publications

(18 citation statements)

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“…Available data indicate antitumor [9], antioxidant [17], anti-inflammatory [22], anti-microbial, anti-viral [23][24][25], anti-diabetic, anti-obesity and hypotensive effects [23][24][25] of catechins. Their beneficial effects on Gram-positive and Gram-negative bacteria, viruses, fungi and prions also need to be emphasized [1].…”

Section: Catechins: Modes Of Actionmentioning

confidence: 99%

Beneficial Properties of Green Tea Catechins

Musiał

Kuban–Jankowska

Górska‐Ponikowska

2020

IJMS

397

250

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Green tea (Camellia sinesis) is widely known for its anticancer and anti-inflammatory properties. Among the biologically active compounds contained in Camellia sinesis, the main antioxidant agents are catechins. Recent scientific research indicates that the number of hydroxyl groups and the presence of characteristic structural groups have a major impact on the antioxidant activity of catechins. The best source of these compounds is unfermented green tea. Depending on the type and origin of green tea leaves, their antioxidant properties may be uneven. Catechins exhibit the strong property of neutralizing reactive oxygen and nitrogen species. The group of green tea catechin derivatives includes: epicatechin, epigallocatechin, epicatechin gallate and epigallocatechin gallate. The last of these presents the most potent anti-inflammatory and anticancer potential. Notably, green tea catechins are widely described to be efficient in the prevention of lung cancer, breast cancer, esophageal cancer, stomach cancer, liver cancer and prostate cancer. The current review aims to summarize the potential anticancer effects and molecular signaling pathways of major green tea catechins. It needs to be clearly emphasized that green tea as well as green tea catechols cannot replace the standard chemotherapy. Nonetheless, their beneficial effects may support the standard anticancer approach.

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Section: Catechins: Modes Of Actionmentioning

confidence: 99%

Beneficial Properties of Green Tea Catechins

Musiał

Kuban–Jankowska

Górska‐Ponikowska

2020

IJMS

397

250

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“…In the last several years, AuNPs (bare or functionalized) have received important attention in nanotherapeutic cancer treatment ( Figure 1) due to their unique properties, which make them suitable candidates for conjugation with targeting ligands, imaging labels, and therapeutic drugs. Also, it has been demonstrated that functionalized AuNPs can be used for targeted molecular imaging and localized surface plasmon resonance (LSPR) [7][8][9].…”

Section: Introductionmentioning

confidence: 99%

Tailored Gold Nanoparticles for Cancer Imaging and Therapy

David

Grumezescu

2019

Mater Int

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In recent years, nanomedicine focused on the development of functional AuNPs for biomedical imaging, attributed to the intriguing optical properties of these nanoparticles, which are discussed in this review. Moreover, are presented the most important in vivo diagnostic techniques which have benefited from the development of engineered AuNPs, such as computed tomography and photothermal/photoacoustic imaging. Another important advantage related to these nanoparticles refers to their excellent performance in recent in vivo studies and clinical trials. Also, side effects of conventional drugs have been minimized by conjugation of AuNPs.

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“…The following formula was used for calculating the hemolysis rate. 28 Haemolysis (%) = (OD Sample -OD Negative )/(OD Positive -OD Negative ) X 100…”

Section: Hemolysis Test Of the Plga-pba@mtxmentioning

confidence: 99%

“…The cellular internalization mechanism was studied using a previously described method by our group. 28 For this study, a non-toxic concentration of MTX (520 nM for MDA-MB-231 and 13 μM for MCF-7) which is present in PLGA-PBA@MTX nanoparticles, was incubated with: (a) cells at 4°C and 37°C without any inhibitors; (b) cells in presence of clathrinmediated endocytosis blocker; (c) cells in presence of caveolaemediated endocytosis blocker and (d) cells in presence of macro-pinocytosis blocker. For this purpose, MDA-MB-231 and MCF-7 cells were grown in poly-L-lysine treated coverslip and treated with 50μM of chlorpromazine (affecting the clathrin lattice assembly), 50 μM of lovastatin (block the lipid raft mediated endocytosis via cholesterol depletion) and 100 μM of amiloride (block macro-pinocytosis via sub-membranous acidification).…”

Section: Pathway Blocking Studymentioning

confidence: 99%

“…For this purpose, MDA-MB-231 and MCF-7 cells were grown in poly-L-lysine treated coverslip and treated with 50μM of chlorpromazine (affecting the clathrin lattice assembly), 50 μM of lovastatin (block the lipid raft mediated endocytosis via cholesterol depletion) and 100 μM of amiloride (block macro-pinocytosis via sub-membranous acidification). 28,29,30,31,32 After treatment with the blockers, cells were incubated with PLGA-PBA@MTX for 2h at 37°C. For the energy-dependent study, cells were incubated for 30min at 4°C followed by the nanoparticles treatment for 2 h at 4°C.…”

Section: Pathway Blocking Studymentioning

confidence: 99%

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