Gold nanoparticle-assisted enhancement in bioactive properties of Australian native plant extracts, Tasmannia lanceolata and Backhousia citriodora

Khandanlou, Roshanak; Murthy, Vinuthaa; Wang, Hao

doi:10.1016/j.msec.2020.110922

Cited by 26 publications

(13 citation statements)

References 69 publications

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“…Likewise, oxyacanthine (C 37 H 40 N 2 O 6 , 608.28863) attenuated cell proliferation ability and promoted cell apoptosis in mammary, prostatic, liver cancers cells [ 32 ], while stearic acid [ 33 ] (C 18 H 36 O 2 ; 284.2715) and grandifloric acid [ 34 ] (terpene; C 20 H 30 O 3 ; 318.2194) had the same action on HepG2 cells. A recent study determined the antiproliferative activity of extracts from Australian plants leaves that contained matricin (C 17 H 22 O 5 ; 306.1467), a prenol lipid, on HepG2 cells [ 35 ].…”

Section: Resultsmentioning

confidence: 99%

Metabolomic Profile and Cytotoxic Activity of Cissus incisa Leaves Extracts

Nocedo-Mena

Rios

Ramírez-Cisneros

et al. 2021

Plants

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Cissus incisa leaves have been traditionally used in Mexican traditional medicine to treat certain cancerous illness. This study explored the metabolomic profile of this species using untargeted technique. Likewise, it determined the cytotoxic activity and interpreted all data by computational tools. The metabolomic profile was developed through UHPLC-QTOF-MS/MS for dereplication purposes. MetaboAnalyst database was used in metabolic pathway analysis and the network topological analysis. Hexane, chloroform/methanol, and aqueous extracts were evaluated on HepG2, Hep3B, HeLa, PC3, A549, and MCF7 cancer cell lines and IHH immortalized hepatic cells, using Cell Titer proliferation assay kit. Hexane extract was the most active against Hep3B (IC50 = 27 ± 3 μg/mL), while CHCl3/MeOH extract was the most selective (SI = 2.77) on the same cell line. A Principal Component Analysis (PCA) showed similar profiles between the extracts, while a Venn diagram revealed 80 coincident metabolites between the bioactive extracts. The sesquiterpenoid and triterpenoid biosynthesis pathway was the most significant identified. The Network Pharmacology (NP) approach revealed several targets for presqualene diphosphate, phytol, stearic acid, δ-tocopherol, ursolic acid and γ-linolenic acid, involved in cellular processes such as apoptosis. This work highlights the integration of untargeted metabolomic profile and cytotoxic activity to explore plant extracts, and the NP approach to interpreting the experimental results.

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Section: Resultsmentioning

confidence: 99%

Metabolomic Profile and Cytotoxic Activity of Cissus incisa Leaves Extracts

Nocedo-Mena

Rios

Ramírez-Cisneros

et al. 2021

Plants

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“…The preparation of NPs could be assisted with natural extracts and used for stabilize or encapsulate the bioactive compounds from same plant or other plants (Esmaile, Koohestani, & Abdollah‐Pour, 2020; Patil et al., 2019); their morphology, loading efficiency, drug release, and the bioactivities depend on the operation parameters (Khan, Saeed, & Khan, 2019; Khandanlou, Murthy, & Wang, 2020; Rajan, Vilas, & Philip, 2015; Ranoszek‐Soliwoda et al., 2019).…”

Section: Preparation Of Nanoparticlesmentioning

confidence: 99%

Bioavailability and antioxidant activity of nanotechnology‐based botanic antioxidants

Myint

Xia

et al. 2021

Journal of Food Science

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Botanic bioactive substances have issues with their solubility, stability, and oral bioavailability in the application, which could be improved by nanotechnologies. In another hands, green synthesis of nanoparticles (NPs) with plant extract is also a promising technology for preparation of NPs due to its safety advantage, yet the bioactive botanic substances that could be more than the assistant of the green synthesis of NPs. Based on the above concerns, this review summarized the preparation of botanic NPs with various plant extract, their solubility, stability, and oral bioavailability; specific attention has been paid to the botanic Ag/Au NPs, their capacity of antioxidant, bioavailability, antimicrobial, anti‐inflammatory, and anticancer.

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“…The characteristic peaks of CJ and CJ-AuNPs at 1704.9-1508.2 cm -1 represented the C=O and C=C vibrations in the carbonyl group, confirming the presence of flavonoids in CJ and CJ-AuNPs 19 . Previous studies have reported the roles of the O-H and C=O groups of terpenoids, flavonoids, flavones, and phenolic compounds as capping, reducing, and stabilizing agents for NPs green synthesis 5 . From above results, we verified the reduction of gold ions by CJ phytochemicals and the formation of an organic coating on the AuNPs surface, which could enhance their biological effects.…”

Section: Resultsmentioning

confidence: 99%

“…Nanoparticles (NPs) occupy a pivotal position in various fields, such as biomedical development, pharmaceutical research, diagnosis, and drug delivery 4 . In particular, nanotechnology has great potential in the early stages of cancer detection and treatment because of its shape and size, which contribute to its targeted and toxic potential 5 . Gold nanoparticles (AuNPs) are among the most widely used nanomaterials in biomedical therapeutics because of their strong surface plasmon resonance and highly optimized protocols 6 .…”

Section: Introductionmentioning

confidence: 99%

Biologically synthesis of gold nanoparticles using Cirsium japonicum var. maackii extract and the study of anti-cancer properties on AGS gastric cancer cells

Park

Dhandapani

et al. 2022

Int. J. Biol. Sci.

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Plant extract-mediated synthesis of metal nanoparticles (NPs) is an eco-friendly and cost-effective biosynthesis method that is more suitable for biological applications than chemical ones. We prepared novel gold NPs (AuNPs), Cirsium japonicum mediated-AuNPs (CJ-AuNPs), using a biosynthetic process involving Cirsium japonicum (Herba Cirsii, CJ) ethanol extract. The physicochemical properties of CJ-AuNPs were characterized using spectrometric and microscopic analyses. The in vitro stability of CJ-AuNPs was studied for 3 months. Moreover, the selective human gastric adenocarcinoma (AGS) cell killing ability of CJ-AuNPs was verified in cancer and normal cells. An in vitro study revealed that CJ-AuNPs trigger oxidative stress and iron-dependent ferroptosis in AGS cells. Mechanistically, CJ-AuNPs induced mitochondrial reactive oxygen species (ROS), Fe 2+ , and lipid peroxidation accumulation, and mitochondrial damage by destroying the glutathione peroxidase-4 (GPX4)-dependent antioxidant capacity. Furthermore, in a xenograft mouse model implanted with AGS cells, treatment with 2.5, 5, and 10 mg/kg CJ-AuNPs for 16 days reduced tumor xenograft growth in a dose dependent manner in vivo without systemic toxicity. These results demonstrate that CJ-AuNPs exert anticancer effects in vitro and in vivo by inducing ferroptosis-mediated cancer cell death. This study, based on green-synthesized nanodrug-induced ferroptosis, provides new insight into potential developments in cancer therapies.

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Gold nanoparticle-assisted enhancement in bioactive properties of Australian native plant extracts, Tasmannia lanceolata and Backhousia citriodora

Cited by 26 publications

References 69 publications

Metabolomic Profile and Cytotoxic Activity of Cissus incisa Leaves Extracts

Metabolomic Profile and Cytotoxic Activity of Cissus incisa Leaves Extracts

Bioavailability and antioxidant activity of nanotechnology‐based botanic antioxidants

Biologically synthesis of gold nanoparticles using Cirsium japonicum var. maackii extract and the study of anti-cancer properties on AGS gastric cancer cells

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