Gold nanoparticle-assembled capsules and their application as hydrogen peroxide biosensor based on hemoglobin

Xuan, Jie; Jia, X.J.; Jiang, Liping; Abdel-Halim, E.S.; Zhu, Jun‐Jie

doi:10.1016/j.bioelechem.2011.10.007

Cited by 50 publications

(20 citation statements)

References 28 publications

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“…At the molecular level, amino groups and carboxyl groups in Hb and chitosan are responsible for opposite behaviors toward Fe(CN) 6 3− between pH value of 4.0 and 8.0, (chitosan, Hb). Chitosan assists in the formation of the chitosan-Hb membrane and provides a favorable environment for Hb [12,22]. So the addition of chitosan enhances the performance of the pHswitchable procedure.…”

Section: A Study On the Mechanismmentioning

confidence: 97%

“…To date, metal nanomaterials have been extensively used as components to fabricate biosensors due to their unique large surface area and improved conductivity [13][14][15][16][17][18][19][20][21][22]. For example, Au-NPs were used to enhance electron exchange between redox enzymes immobilized on the surface of electrodes in our previous works [23][24][25].…”

Section: Introductionmentioning

confidence: 99%

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Glassy carbon electrode modified with gold nanoparticles and hemoglobin in a chitosan matrix for improved pH-switchable sensing of hydrogen peroxide

et al. 2015

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Hemoglobin (Hb) has been demonstrated to endow electrochemical sensors with pH-switchable response because of the presence of carboxyl and amino groups. Hb was deposited in a chitosan matrix on a glassy carbon electrode (GCE) that was previously coated with clustered gold nanoparticles (Au-NPs) by electrodeposition. The switching behavior is active ("on") to the negatively charged probe [Fe(CN) 63− ] at pH 4.0, but inactive ("off") to the probe at pH 8.0. This switch is fully reversible by simply changing the pH value of the solution and can be applied for pH-controlled reversible electrochemical reduction of H 2 O 2 catalyzed by Hb. The modified electrode was tested for its response to the different electroactive probes. The response to these species strongly depends on pH which was cycled between 4 and 8. The effect is also attributed to the presence of pH dependent charges on the surface of the electrode which resulted in either electrostatic attraction or repulsion of the electroactive probes. The presence of Hb, in turn, enhances the pH-controllable response, and the electrodeposited Au-NPs improve the capability of switching. This study reveals the potential of protein based pH-switchable materials and also provides a simple and effective strategy for fabrication of switchable chemical sensors as exemplified in a pH-controllable electrode for hydrogen peroxide.

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Section: A Study On the Mechanismmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

Glassy carbon electrode modified with gold nanoparticles and hemoglobin in a chitosan matrix for improved pH-switchable sensing of hydrogen peroxide

et al. 2015

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“…It is well known that nanoparticles have unique photonic, electronic, magnetic and catalytic attributes, and that their physical and chemical properties are related to their structures and morphologies [1]. Many different types of nanoparticle have been synthesized in various ways, and in this context, many different metallic nanostructures have been reported.…”

Section: Introductionmentioning

confidence: 99%

Electrochemical hydrogen peroxide sensor based on a glassy carbon electrode modified with nanosheets of copper-doped copper(II) oxide

Song

You

et al. 2015

Microchim Acta

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A new electrochemical sensor for H 2 O 2 was constructed by depositing copper doped CuO nanosheets on a glassy carbon electrode (GCE). The morphology and composition of the modified electrode were characterized via scanning electron microscopy, energy dispersive X-ray spectroscopy and X-ray diffraction. The electrochemical properties of the electrode were studied using cyclic voltammetry and electrochemical impedance spectroscopy. The catalytic performance of the sensor was studied in 100 mM NaOH solution via differential pulse voltammetry and revealed the sensor to display significantly improved electrocatalytic activity with respect to the analysis of the H 2 O 2 in comparison to a plain GCE or a GCE modified with copper only. The response to H 2 O 2 at a working voltage of −0.46 V (vs. Ag/AgCl) is linear in the 0.003 -8 mM concentration range, and the detection limit is 0.21 mM (at an S/N ratio of 3). Satisfactory results were obtained in the analysis of tap, rain and river waters spiked with H 2 O 2 . The analytical performance of this electrode compares favorably to the results obtained with other commonly used techniques for analysis of H 2 O 2 .

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“…[1][2][3][4][5][6]. Such expanding applications have resulted in an increased focus on studying the method of synthesis of nanopar ticles.…”

Section: Introductionmentioning

confidence: 99%

Metallic nanoparticles made in flow and their catalytic applications in organic synthesis

Shahbazali

Hessel

Noël

et al. 2014

Nanotechnology Reviews

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This paper reviews recent developments on the synthesis of noble metal nanoparticles in micro and milli fluidic devices and their catalytic application in organic flow synthesis. A variety of synthesis methods using microfluidics is presented for gold, silver, palladium, platinum, and copper nanoparticles, including the for mation in singlephase flows and multiphase flows. In the field of organic chemistry, metal nanoparticles can be used as catalysts. This can lead to remarkably improved reaction performance in terms of minimizing the reaction time and higher yields. In this context, various applica tions of those metal nanoparticles as catalysts in micro fluidic devices are highlighted at selected examples. As a new direction and operational window, nanocatalysts may be synthesized in situ in flow and directly utilized in an organic synthesis. This allows making use of highly active, yet instable catalyst species, which may only have a very short life of a few seconds -a type of flashed nano catalyst organic synthesis.

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Gold nanoparticle-assembled capsules and their application as hydrogen peroxide biosensor based on hemoglobin

Cited by 50 publications

References 28 publications

Glassy carbon electrode modified with gold nanoparticles and hemoglobin in a chitosan matrix for improved pH-switchable sensing of hydrogen peroxide

Glassy carbon electrode modified with gold nanoparticles and hemoglobin in a chitosan matrix for improved pH-switchable sensing of hydrogen peroxide

Electrochemical hydrogen peroxide sensor based on a glassy carbon electrode modified with nanosheets of copper-doped copper(II) oxide

Metallic nanoparticles made in flow and their catalytic applications in organic synthesis

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