Gold Nanoparticle as an Alternative Tool for a Urine Pregnancy Test

Rojanathanes, Rojrit; Sereemaspun, Amornpun; Pimpha, Nuttaporn; Buasorn, Vanida; Ekawong, Prapawadee; Wiwanitkit, Viroj

doi:10.1016/s1028-4559(08)60127-8

Cited by 22 publications

(13 citation statements)

References 5 publications

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“…The ICT format of point-of-care tests is, certainly, the most widely utilized test and it is well known as urinebased pregnancy tests. 18 However, the use of ICT in medicine is now much broader and it is continuing to expand, covering a range of uses such as serodiagnosis, 19 the detection of a bacterial soluble protein in blood, urine, or sputum, 20 the detection of parasites in vaginal swabs, 21 the detection of toxins or viruses in stool, [22][23][24] or the detection of viruses in nasopharyngeal aspirates. 25 An ICT has been also demonstrated for the detection of prostate-specific antigen as a screen for prostate cancer 26 and the ICT concept might also be developed to detect environmental contamination (for a review of ICTs, see e.g., Posthuma-Trumpie et al 27 ) In this study, an ICT test, intended to become a screening test for the triage of persons having inhaled ricin, was tested against ricins extracted from 19 cultivars collected from various countries throughout the world.…”

Section: Discussionmentioning

confidence: 99%

Broad recognition of ricin toxins prepared from a range ofRicinuscultivars using immunochromatographic tests

Thullier¹,

Griffiths²

2009

Clinical Toxicology

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Section: Discussionmentioning

confidence: 99%

Broad recognition of ricin toxins prepared from a range ofRicinuscultivars using immunochromatographic tests

Thullier¹,

Griffiths²

2009

Clinical Toxicology

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“…Depending on the size of the AuNPs, controlled aggregation of the particles can result in colour changes, [13][14][15] from pink to violet to pale blue. This phenomenon has been used in home pregnancy tests and in analyses for specific gene sequences 16,17 and for colorimetric detection of a variety of analytes. [18][19][20] It is the anticipated colour changes during aggregation (or dispersion of aggregates) that provide a platform for colorimetric detection using AuNPs as signal transducers.…”

Section: -5mentioning

confidence: 99%

Gold nanoparticle-based colorimetric biosensors

et al. 2018

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Gold nanoparticles (AuNPs) provide excellent platforms for the development of colorimetric biosensors as they can be easily functionalised, displaying different colours depending on their size, shape and state of aggregation. In the last decade, a variety of biosensors have been developed to exploit the extent of colour changes as nano-particles (NPs) either aggregate or disperse, in the presence of analytes. Of critical importance to the design of these methods is that the behaviour of the systems has to be reproducible and predictable. Much has been accomplished in understanding the interactions between a variety of substrates and AuNPs, and how these interactions can be harnessed as colorimetric reporters in biosensors. However, despite these developments, only a few biosensors have been used in practice for the detection of analytes in biological samples. The transition from proof of concept to market biosensors requires extensive long-term reliability and shelf life testing, and modification of protocols and design features to make them safe and easy to use by the population at large. Developments in the next decade will see the adoption of user friendly biosensors for point-of-care and medical diagnosis as innovations are brought to improve the analytical performances and usability of the current designs. This review discusses the mechanisms, strategies, recent advances and perspectives for the use of AuNPs as colorimetric biosensors.

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“…In osteoporosis, various bone turnover markers could be measured quickly and easily using point-of-care tests by nanoparticle based immunoassay. Essentially, immunoassays-based on gold nanoparticle aggregation have been used in numerous ways to characterize ligand-receptor interactions, for example, they have been used for pregnancy testing (Rojanathanes et al, 2008), and for investigating the cellular interactions of human cells and DNA hybridization (Zhu et al, 2006).…”

Section: Introductionmentioning

confidence: 99%