Gold nanomaterials as key suppliers in biological and chemical sensing, catalysis, and medicine

Falahati, Mojtaba; Attar, Farideh; Sharifi, Majid; Saboury, Ali Akbar; Salihi, Abbas; Aziz, Falah Mohammad; Kostova, Irena; Burda, Clemens; Priecel, Peter; López-Sánchez, José Antonio; Laurent, Sophie; Hooshmand, Nasrin; El‐Sayed, Mostafa A.

doi:10.1016/j.bbagen.2019.129435

Cited by 97 publications

(59 citation statements)

References 426 publications

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“…The excited PS will transfer energy to the surrounding O 2 to generate reactive oxygen species (ROS) and increase ROS level in the target sites. ROS can react with adjacent biological macromolecules to produce significant cytotoxicity, cell damage, even death or apoptosis ( Imanparast et al, 2018 ; Falahati et al, 2019 ; Singh et al, 2020 ). As a PS, AuNPs can absorb the NIR light, accumulate in the tumor area, raise the temperature, and generate high levels of ROS, which can ultimately damage the tumor growth and promote cancer cell death ( Jing et al, 2014 ).…”

Section: Medical Applications Of Multifunctional Aunpsmentioning

confidence: 99%

Multifunctional Gold Nanoparticles: A Novel Nanomaterial for Various Medical Applications and Biological Activities

Zhang

Ding

et al. 2020

Front. Bioeng. Biotechnol.

356

206

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Nanotechnology has become a trending area in science and has made great advances with the development of functional, engineered nanoparticles. Various metal nanoparticles have been widely exploited for a wide range of medical applications. Among them, gold nanoparticles (AuNPs) are widely reported to guide an impressive resurgence and are highly remarkable. AuNPs, with their multiple, unique functional properties, and easy of synthesis, have attracted extensive attention. Their intrinsic features (optics, electronics, and physicochemical characteristics) can be altered by changing the characterization of the nanoparticles, such as shape, size and aspect ratio. They can be applied to a wide range of medical applications, including drug and gene delivery, photothermal therapy (PTT), photodynamic therapy (PDT) and radiation therapy (RT), diagnosis, X-ray imaging, computed tomography (CT) and other biological activities. However, to the best of our knowledge, there is no comprehensive review that summarized the applications of AuNPs in the medical field. Therefore, in this article we systematically review the methods of synthesis, the modification and characterization techniques of AuNPs, medical applications, and some biological activities of AuNPs, to provide a reference for future studies.

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Section: Medical Applications Of Multifunctional Aunpsmentioning

confidence: 99%

Multifunctional Gold Nanoparticles: A Novel Nanomaterial for Various Medical Applications and Biological Activities

Zhang

Ding

et al. 2020

Front. Bioeng. Biotechnol.

356

206

View full text Add to dashboard Cite

show abstract

“…On the other hand, some limitations in targeted drug delivery 13 result in severe toxicity to liver, kidney and spleen [13][14][15] , as well as the poor distribution of anti-cancer drugs in tumor site 6,16 . Therefore, several strategies like development of some NP-based platforms for targeted drug delivery have been reported 4,17,18 .…”

mentioning

confidence: 99%

Combined chemo-magnetic field-photothermal breast cancer therapy based on porous magnetite nanospheres

Sharifi

Hasan

Nanakali

et al. 2020

Sci Rep

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The efficacy of different modalities of treating breast cancer is inhibited by several limitations such as off-targeted drug distribution, rapid drug clearance, and drug resistance. To overcome these limitations, we developed Lf-Doxo-PMNSs for combined chemo-MF-PTT. The PMNSs were synthesized by hydrothermal method and their physicochemical properties were examined by FE-SEM, TEM, DLS, TGA, XRD investigations. The cytotoxicity of as-synthesized NPs against 4T1 cells was carried out by MTT and flow cytometry assays. Afterwards, the anti-cancer activities of as-synthesized Lf-Doxo-PMNSs on the tumor status, drug distribution and apoptosis mechanism were evaluated. The anti-cancer assays showed that Lf-Doxo-PMNSs significantly suppressed the cancer cell proliferation and tumor weight by prolonging drug availability and potential drug loading in tumor cells; whereas they showed a minimum cytotoxicity against non-cancerous cells. Likewise, combined chemo-MF-PTT using Lf-Doxo-PMNSs displayed the highest anti-cancer activity followed by combined chemo-PTT and combined chemo-MF therapy based on altering the apoptosis mechanism. Therefore, these results showed that combined chemo-MF-PTT based on Lf-Doxo-PMNSs can be used as a promising therapeutic platform with potential targeted drug delivery and high loading capacity features as well as reducing cancer drug resistance.

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“…With the advent of nanotechnology in the 1960s, this technology has received a great deal of attention in various fields of biomedicine, with the improvement of biological and chemical analysis based on unique optical, electrochemical, magnetical, and mechanical properties [ 33 , 92 ]. However, as mentioned earlier, the first use of nanomaterials in the detection of viruses in the late 1990s was used to detect human papillomavirus [ 93 ].…”

Section: Application Of Nanobiosensors In Covid-19 Detectionmentioning

confidence: 99%

Rapid diagnostics of coronavirus disease 2019 in early stages using nanobiosensors: Challenges and opportunities

Sharifi

Hasan

Haghighat

et al. 2021

Talanta

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The rapid outbreak of coronavirus disease 2019 (COVID-19) around the world is a tragic and shocking event that demonstrates the unpreparedness of humans to develop quick diagnostic platforms for novel infectious diseases. In fact, statistical reports of diagnostic tools show that their accuracy, specificity and sensitivity in the detection of COVID-face challenges that can be eliminated by using nanoparticles (NPs). In this study, we aimed to present an overview on the most important way to diagnose different kinds of viruses followed by the introduction of nanobiosensors. Afterward, some methods of coronavirus detection such as imaging, laboratory and kit-based diagnostic tests are surveyed. Furthermore, nucleic acids/protein- and-immunoglobulin (Ig)-based nanobiosensors for the COVID-19 detection infection are reviewed. Finally, current challenges and future perspective for the development of diagnostic or monitoring technologies in the control of COVID-19 are discussed to persuade the scientists in advancing their technologies beyond imagination. In conclusion, it can be deduced that as rapid COVID-19 detection infection can play a vital role in disease control and treatment, this review may be of great help for controlling the COVID-19 outbreak by providing some necessary information for the development of portable, accurate, selectable and simple nanobiosensors.

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Gold nanomaterials as key suppliers in biological and chemical sensing, catalysis, and medicine

Cited by 97 publications

References 426 publications

Multifunctional Gold Nanoparticles: A Novel Nanomaterial for Various Medical Applications and Biological Activities

Multifunctional Gold Nanoparticles: A Novel Nanomaterial for Various Medical Applications and Biological Activities

Combined chemo-magnetic field-photothermal breast cancer therapy based on porous magnetite nanospheres

Rapid diagnostics of coronavirus disease 2019 in early stages using nanobiosensors: Challenges and opportunities

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