Gold Nanomaterials and Bone/Cartilage Tissue Engineering: Biomedical Applications and Molecular Mechanisms

Shi, Yifeng; Han, Xuyao; Pan, Shuang; Wu, Yuhao; Jiang, Yuhan; Lin, Jinghao; Chen, Yihuang; Jin, Haiming

doi:10.3389/fchem.2021.724188

Cited by 17 publications

(12 citation statements)

References 91 publications

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“…On the other hand, nanogold (13 nm, 10 μg) could inhibit the mechanism of RA by binding to VEGF and inhibiting the proliferation and migration of endothelial cells. AuNPs (13 or 50 nm; 3.76 μg) can also inhibit ROS and prevent the destruction of RA synovitis [ 7 ]. Therefore, AuNPs can inhibit angiogenic activity, inhibit inflammation, or act as antioxidants, to protect cartilage tissue in arthritis.…”

Section: Bone Cartilage Disordermentioning

confidence: 99%

“…Therefore, AuNPs can inhibit angiogenic activity, inhibit inflammation, or act as antioxidants, to protect cartilage tissue in arthritis. Studies have shown that AuNPs have the ability to inhibit osteoclasts and are one of the most effective nanoparticles for the treatment of bone tissue diseases [ 7 , 39 ].…”

Section: Bone Cartilage Disordermentioning

confidence: 99%

“…With the difference in nanoscale, gold changes from red to purple. Gold nanoparticles, due to their excellent properties, such as easy synthesis, controllable size, specific surface plasmon resonance, and excellent biocompatibility, have shown fascinating feasibility for the treatment of various diseases [ 7 ]. Therefore, the content of this review article is based on the foundational research of nanogold particles in recent years, with the goal of understanding their physiological and pharmacological functions in various organ systems and diseases ( Figure 1 and Table 1 ).…”

Section: Introductionmentioning

confidence: 99%

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Pharmacological Role of Functionalized Gold Nanoparticles in Disease Applications

Wang

Hsiao

et al. 2022

Molecules

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Gold has always been regarded as a symbol of nobility, and its shiny golden appearance has always attracted the attention of many people. Gold has good ductility, molecular recognition properties, and good biocompatibility. At present, gold is being used in many fields. When gold particles are as small as several nanometers, their physical and chemical properties vary with their size in nanometers. The surface area of a nano-sized gold surface has a special effect. Therefore, gold nanoparticles can, directly and indirectly, give rise to different biological activities. For example, if the surface of the gold is sulfided. Various substances have a strong chemical reactivity and are easy to combine with sulfhydryl groups; hence, nanogold is often used in biomedical testing, disease diagnosis, and gene detection. Nanogold is easy to bind to proteins, such as antibodies, enzymes, or cytokines. In fact, scientists use nanogold to bind special antibodies, as a tool for targeting cancer cells. Gold nanoparticles are also directly cytotoxic to cancer cells. For diseases caused by inflammation and oxidative damage, gold nanoparticles also have antioxidant and anti-inflammatory effects. Based on these unique properties, gold nanoparticles have become the most widely studied metal nanomaterials. Many recent studies have further demonstrated that gold nanoparticles are beneficial for humans, due to their functional pharmacological properties in a variety of diseases. The content of this review will be the application of gold nanoparticles in treating or diagnosing pressing diseases, such as cancers, retinopathy, neurological diseases, skin disorders, bowel diseases, bone cartilage disorders, cardiovascular diseases, infections, and metabolic syndrome. Gold nanoparticles have shown very obvious therapeutic and application potential.

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Section: Bone Cartilage Disordermentioning

confidence: 99%

Section: Bone Cartilage Disordermentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Pharmacological Role of Functionalized Gold Nanoparticles in Disease Applications

Wang

Hsiao

et al. 2022

Molecules

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“…Therefore, developing fast and accurate hydrogen sensors is of great importance for safely using hydrogen energy. Hydrogen sensors based on various structures and mechanisms have been reported in the past decade, including micro-electro-mechanical systems, semiconductors, optical, , electrochemical, TE, , and other hybrid catalytic systems. − TE hydrogen sensors (TEHs) attracted the attention of researchers for their high selectivity, fast response, low power consumption, and minimum maintenance requirements …”

Section: Introductionmentioning

confidence: 99%

Self-Powered Thermoelectric Hydrogen Sensors Based on Low-Cost Bismuth Sulfide Thin Films: Quick Response at Room Temperature

Lien

et al. 2022

ACS Appl. Mater. Interfaces

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Thermoelectric (TE)-based gas sensors have attracted significant attention due to their high selectivity, low power consumption, and minimum maintenance requirements. However, it is challenging to find low-cost, environmentally friendly materials and simple device fabrication processes for large-scale applications. Herein, we report self-powered thermoelectric hydrogen (TEH) sensors based on bismuth sulfide (Bi2S3) fabricated from a low-cost Bi2S3 TE layer and platinum (Pt) catalyst. When working at room temperature, the monomorphic-type TEH sensor obtained an output response signal of 42.2 μV with a response time of 17 s at a 3% hydrogen atmosphere. To further improve device performance, we connected the patterned Bi2S3 films in series to increase the Seebeck coefficient to −897 μV K–1. For comparison, the resulting N tandem-type TEH sensor yielded a distinguished output voltage of 101.4 μV, which was greater than the monomorphic type by a factor of 2.4. Significantly, the response and recovery time of the N-tandem-type TEH sensor to 3% hydrogen were shortened to 14 and 15 s, respectively. This work provides a simple, environmentally friendly, and low-cost strategy for fabricating high-performance TEH sensors by applying low-cost Bi2S3 TE materials.

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“…In addition, the more sensitive and collective biosensor is potential. Meanwhile, the nanomaterials are the most potential and hot one [1].…”

Section: Introductionmentioning

confidence: 99%

Applications of Gold Nanomaterials in Biomedicine

Wu,

Wang

2022

HSET

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With more deeply recent researches and studies about nanomaterials, such as nanoparticles, nanospheres and nanoshells, scientists found that nanomaterials have some specific advantages in terms of physical and chemical, optical, nuclear characteristics due to quantum size effect, which are ideally satisfied strict demand of high sensitivity and accuracy of biosensors. Nowadays, nanomaterials are widely used in the detection and treatment in medical domain. Among many categories of nanoparticles, gold nanomaterials are the most attractive one. As a result, this research mainly introduces a number of applications based on gold nanomaterials in different fields, such as DNA detection, cell imaging, protein detection and disease treatment. It will hope this research would expand the knowledge sight of advanced nanotechnology of readers. However, there also have many aspects of applications of gold nanomaterials waited to be found in future.

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Gold Nanomaterials and Bone/Cartilage Tissue Engineering: Biomedical Applications and Molecular Mechanisms

Cited by 17 publications

References 91 publications

Pharmacological Role of Functionalized Gold Nanoparticles in Disease Applications

Pharmacological Role of Functionalized Gold Nanoparticles in Disease Applications

Self-Powered Thermoelectric Hydrogen Sensors Based on Low-Cost Bismuth Sulfide Thin Films: Quick Response at Room Temperature

Applications of Gold Nanomaterials in Biomedicine

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