Gold nanodisc arrays as near infrared metal-enhanced fluorescence platforms with tuneable enhancement factors

Pang, Jiangli; Theodorou, Ioannis G.; Centeno, Anthony; Petrov, Peter K.; Alford, Neil McN.; Ryan, Mary P.; Xie, Fang

doi:10.1039/c6tc04965f

Cited by 40 publications

(46 citation statements)

References 42 publications

(70 reference statements)

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“…Interestingly, instead of complete overlap, it has been shown that enhanced fluorescence occurs when the fluorophore emission peaks at a slightly longer wavelength than the LSPR peak. 23,24 In the past decade, there have been plentiful novel nanoparticle structures showing an ability to improve both the fluorescence intensity and the photostability of fluorophores via this mechanism, including nanorods, 25 nanocubes, 26 nanodisks, 27 nanotriangles 28 and nanostars 29 (Fig. 3A 30 ).…”

Section: General Criteria For a Mef Based Biosensormentioning

confidence: 99%

“…114 The variability of structures that can be produced is still expanding and ranges from rod arrays to rings, discs and crescents. 27,[115][116][117] In 2016, the amplification of light in NIR-II from Ag 2 S quantum dots was reported for the first time, achieving an enhancement of over 100 times when conjugated to nanotriangular arrays as produced via colloidal lithography. 67 Most notably, in 2017, protein microarrays based on NIR plasmonic gold nanostructures were reported for the highly sensitive detection of the pancreatic biomarker CA19-9.…”

Section: Towards Nir I and Nir Ii Biosensingmentioning

confidence: 99%

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Metal enhanced fluorescence biosensing: from ultra-violet towards second near-infrared window

2018

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Section: General Criteria For a Mef Based Biosensormentioning

confidence: 99%

Section: Towards Nir I and Nir Ii Biosensingmentioning

confidence: 99%

Metal enhanced fluorescence biosensing: from ultra-violet towards second near-infrared window

2018

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“…This leads to larger field enhancement at the LSPR, leading to a larger excitation enhancement in MEF. The LSPR is dependent not just upon material but also on the shape of the nanoparticle, and MEF has been successfully demonstrated in the NIR using triangular-like Ag nanoparticles immobilized on glass substrate [26,27], nanocylinders [22], and Nanostar [23]. Table 1 summarizes some of the results presented in published work by the Xie group at Imperial College for MEF in the NIR, for both Au and Ag nanoparticles, for excitation wavelengths up to 780 nm.…”

Section: Of 13mentioning

confidence: 97%

“…A higher carrier (doping) density is obtainable using ion implantation and annealing. Prucnal et al [22] achieved carrier concentrations of ~2.2 × 10 20 using rear side flash-lamp annealing (r-FLA). This gave n-Ge films of thickness 140 nm.…”

Section: Considering the Extinction Peaks Inmentioning

confidence: 99%

“…One application that exploits the LSPR, which has received much attention for the purpose of bio-sensing, is metal enhanced fluorescence (MEF) [11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28]. MEF is now a well-recognized form of technology wherein the near-field interaction of fluorophores with metallic nanostructures can lead to substantial fluorescence enhancement.…”

Section: Introductionmentioning

confidence: 99%

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Infra-Red Plasmonic Sensors

Centeno

Aid²,

Xie

2018

Chemosensors

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Plasmonic sensors exploiting the localized surface plasmon resonance (LSPR) of noble metal nanoparticles are common in the visual spectrum. However, bio-sensors near the infra-red (NIR) windows (600-900 nm and 1000-1400 nm) are of interest, as in these regions the absorption coefficients of water, melanin deoxyglobin, and hemoglobin are all low. The first part of this paper reviews the work that has been undertaken using gold (Au) and silver (Ag) particles in metal enhanced fluorescence (MEF) in the NIR. Despite this success, there are limitations, as there is only a narrow band in the visual and NIR where losses are low for traditional plasmonic materials. Further, noble metals are not compatible with standard silicon manufacturing processes, making it challenging to produce on-chip integrated plasmonic sensors with Au or Ag. Therefore, it is desirable to use different materials for plasmonic chemical and biological sensing, that are foundry-compatible with silicon (Si) and germanium (Ge). One material that has received significant attention is highly-doped Ge, which starts to exhibit metallic properties at a wavelength as short as 6 µm. This is discussed in the second part of the paper and the results of recent analysis are included.Fluorescent molecules emitting at wavelengths in the infra-red window, in which penetration depth is high and the autofluorescence minimum is of particular interest, are potentially an attractive technology for bio-applications [27]. However, the low quantum yield and poor photostability of near infra-red (NIR) dyes currently limits their applicability. Design and synthesis of NIR dyes with high quantum yield and photostability have proved to be extremely challenging, due to the complex synthetic routes required for these large, complex molecules [27]. The amplification of light from NIR fluorophores by MEF is a promising strategy for dramatically improving both the detection sensitivity and image enhancement, thereby realizing the potential advantages of the NIR fluorophores. Section 2 of this paper discusses the physical process of MEF and reviews some of the published work by the authors.NIR losses arise in Au and Ag from intraband (or Drude) losses. There is, therefore, only a narrow band in the visual and NIR range where losses are low for traditional plasmonic materials. A further challenge associated with noble metals is that they are not compatible with standard silicon manufacturing processes. Further, noble metals diffuse into the semiconductor, forming deep-level traps which have an adverse effect on device performance. While Au and Ag are the obvious choice for visible and NIR applications, there is a desire and need for chemical and biological sensing in the mid-infrared (MIR) range [29][30][31] using materials that are foundry-compatible with silicon (Si) and germanium (Ge), that might lead to on-chip integration of devices governed by plasmonic effects [25,26]. One material that has received significant attention as a potential plasmonic material in the MIR is highly-...

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Metal‐Enhanced Fluorescence and Its Applications

Sugawa¹

2018

Encyclopedia of Analytical Chemistry

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The fluorescence‐enhancement phenomenon of fluorophores positioned near metal nanostructures (metal‐enhanced fluorescence, MEF) is the result of the interaction between the fluorophores and the localized surface plasmon resonance (LSPR) of the nanostructures. This enhancement phenomenon can contribute to the development of novel sensors based on unprecedented mechanisms, as well as improving the sensitivity of existing biosensors and imaging techniques. In this article, the two main mechanisms for MEF are briefly explained: the light‐harvesting nanoantenna effect and the increase in the radiative decay rate. This is followed by an introduction to metal nanostructures and nanoparticles (substrate‐based platforms and solution‐dispersed colloidal nanoparticle‐based platforms), which can act as MEF platforms. In addition, the efficient suppression of fluorescence blinking and photobleaching induced by the interaction with LSPR are described, as these are secondary advantages for fluorescence‐based sensors. Subsequently, the generation of hot spots, which could be one of the key phenomena for significant fluorescence enhancement, is outlined. An examination of usability of MEF platforms consisting of Al and Cu (metal species other than Au and Ag) to further improve their applicability is also discussed. Finally, some recent applications such as the development of imaging techniques, nanoprobes, and biosensors utilizing the MEF phenomenon are briefly introduced.

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Gold nanodisc arrays as near infrared metal-enhanced fluorescence platforms with tuneable enhancement factors

Abstract: Au nanodisc arrays with nanoscale control of their structural characteristics, allow significant NIR fluorescence enhancement with tunable sensitivities.

Cited by 40 publications

References 42 publications

Metal enhanced fluorescence biosensing: from ultra-violet towards second near-infrared window

Metal enhanced fluorescence biosensing: from ultra-violet towards second near-infrared window

Infra-Red Plasmonic Sensors

Metal‐Enhanced Fluorescence and Its Applications

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