Gold nanoclusters as prospective carriers and detectors of pramipexole

Abstract

Gold clusters as prospective carriers and detectors of pramipexole.

Adsorption/Desorption Behaviors and SERS Chemical Enhancement of 6-Mercaptopurine on a Nanostructured Gold Surface: The Au20 Cluster Model

“…The most stable forms of Au 20 with cysteine (CYS) and its deprotonated form, denoted as CYSa, are presented in Figure 6. As recently reported [49,53,75], these species tend to adsorb on the gold surface via the S-atom of the thiol group. In an aqueous solution, the binding energies to Au 20 were~35 kcal/mol for CYSa and significantly reduced tõ 16 kcal/mol for CYS.…”

“…We then examined the ability to detach the drug from the gold cluster in target cells, which is considered as the decisive step in a drug delivery process [49,75]. In a human body, the drug can be segregated from the carrier by either external stimuli or internal stimuli operated within a biologically controlled manner such as the pH and glutathione [76].…”

“…More recently, similar approaches were also applied to probe the SERS phenomenon of the chlorpyrifos, which is a pesticide using the Ag 20 cluster as a model for the silver surface [89]. Likewise, the tetrahedral gold Au 20 cluster was also used as a model to validate the SERS spectrum of pramipexole molecules adsorbed on the gold surfaces [75]. Previous reports are also available on the Raman characteristics of 6MP as well as its SERS phenomenon on gold surfaces [68,84,90].…”

Pristine and alkali and alkaline earth metals encapsulated B36N36 nanoclusters as prospective delivery agents and detectors for 5‐fluorouracil anticancer drug

“…Owing to the excessive lactic production, a cancer cell has generally more acidic than normal cells (pH < 6). [83,84] Thus, it is necessary to evaluate the effect of the protons on the stability of the considered complexes. The most suitable positions for protonation of the FU molecule are obviously the O atoms, which are rich in electrons.…”

Synthesis, molecular docking, and biological evaluation of 5‐alkyl(aryl)‐2‐isobutylthiazole derivatives: As α‐amylase, α‐glucosidase, and protein kinase inhibitors

“…Thiazole derivatives have a broad spectrum of activities, namely, antidiabetic [4], antibacterial [5], antiviral [6], antifungal [7], anticancer [8], anti‐inflammatory [4], antimalarial [9], antitubercular [10], anthelmintic [11], antioxidant [12], anticonvulsant [13], cardiovascular [2], and analgesic and antipyretic [14]. Pioglitazone and rosiglitazone [15], meloxicam, cefotaxime, thiamin (vitamin B12), dasatinib, dabrafenib, pramipexole, nizatidine, and so forth [2, 16, 17] are the most known examples of drugs containing thiazole ring (Scheme 1).…”