Gold Nanocluster Embedded Albumin Nanoparticles for Two‐Photon Imaging of Cancer Cells Accompanying Drug Delivery

Khandelia, Rumi; Bhandari, Satyapriya; Pan, Uday Narayan; Ghosh, Siddhartha Sankar; Chattopadhyay, Arun

doi:10.1002/smll.201500216

Cited by 139 publications

(133 citation statements)

References 42 publications

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“…In this regard, multifunctional nanostructures based on albumin have provided a new paradigm for advanced drug delivery and theranostic applications. For example, a recent study introduced a composite NP consisting of Au nanoclusters embedded in BSA NPs for DOX delivery to cervical cancer HeLa cells and for cell imaging through photonic excitation (Figure 5(a)) [131]. The nanostructures showed good stability and retention of their luminescence and were well taken up by cells.…”

Section: Cancer Treatmentmentioning

confidence: 99%

Albumin nanostructures as advanced drug delivery systems

Karimi

Bahrami

Ravari

et al. 2016

Expert Opinion on Drug Delivery

310

190

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Introduction One of the biggest impacts that the nanotechnology has made on medicine and biology, has been in the area of drug delivery systems (DDSs). Many drugs suffer from serious problems concerning insolubility, instability in biological environments, poor uptake into cells and tissues, suboptimal selectivity for targets and unwanted side effects. Nanocarriers can be designed as DDSs to overcome many of these drawbacks. One of the most versatile building blocks to prepare these nanocarriers is the ubiquitous, readily available and inexpensive protein, serum albumin. Areas covered This review covers the use of different types of albumin (human, bovine, rat, and chicken egg) to prepare nanoparticle and microparticle-based structures to bind drugs. Various methods have been used to modify the albumin structure. A range of targeting ligands can be attached to the albumin that can be recognized by specific cell receptors that are expressed on target cells or tissues. Expert opinion The particular advantages of albumin used in DDSs include ready availability, ease of chemical modification, good biocompatibility, and low immunogenicity. The regulatory approvals that have been received for several albumin-based therapeutic agents suggest that this approach will continue to be successfully explored.

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Section: Cancer Treatmentmentioning

confidence: 99%

Albumin nanostructures as advanced drug delivery systems

Karimi

Bahrami

Ravari

et al. 2016

Expert Opinion on Drug Delivery

310

190

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“…[67] This nuclei targeting is also the origin of several drug delivery studies, [68][69][70][71] such as DOX delivery via AuNC@BSA combined with two-photon imaging. [72] AuNCs were also covalently grafted on non-porous silica NPs for cytosol imaging and reactive oxygen species detection via the quenching of the gold fluorescence, [73] however, AuNCs were not combined with MSN.…”

Section: Accepted M Manuscriptmentioning

confidence: 99%

Protein-gold clusters-capped mesoporous silica nanoparticles for high drug loading, autonomous gemcitabine/doxorubicin co-delivery, and in-vivo tumor imaging

Croissant¹,

Zhang

Alsaiari

et al. 2016

Journal of Controlled Release

152

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, Protein-gold clusters-capped mesoporous silica nanoparticles for high drug loading, autonomous gemcitabine/doxorubicin co-delivery, and in-vivo tumor imaging, Journal of Controlled Release (2016Release ( ), doi: 10.1016Release ( /j.jconrel.2016 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.A C C E P T E D M A N U S C R I P T ACCEPTED MANUSCRIPT

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“…Moreover, they also presented that the fluorescent AuNCs could be used in CT imaging. Moreover, the biocompatible GSH-AuNCs and functionalized BSAAuNCs have been also used for two-photon fluorescence imaging of tumor cells [145,146]. For instance, Khandelia et al reported the usage of BSA-stabilized AuNCs for in vitro delivery of hydrophilic drug doxorubicin (DOX) to cancer cells [146].…”

Section: Biological Imagingmentioning

confidence: 99%

“…13 Schematic illustration of the formation of DOX loaded BSA stabilized AuNCs, followed by uptake and release of DOX inside the HeLa cells, in addition to two-photon imaging. Reprinted with permission [146] …”

Section: Summary and Perspectivementioning

confidence: 99%

Fluorescent Gold Nanoclusters: Promising Fluorescent Probes for Sensors and Bioimaging

Wang

Zhu

2017

J. Anal. Test.

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Fluorescent gold nanoclusters (AuNCs) have recently emerged as a novel kind of promising fluorescent probes for high-performance sensors and bioimaging because of their ultrasmall size (\3 nm), strong luminescence, good photostability, and excellent biocompatibility. Over the past decade, we have witnessed growing popularity of AuNCs in analytical applications and enormous efforts have been devoted to their development. In this review, we provide an update on recent advances in the development of AuNCs in terms of physicochemical properties, synthesis strategies, and bioapplications. The optical, electrochemical, catalytical, and solvatochromic properties of AuNCs are first summarized, which are followed by different ligands or template-assisted controllable synthetic methods. Afterwards functionalization of AuNCs is described in terms of ligand exchange, bioconjugation, and noncovalent interaction. We then focus on the applications of AuNCs as fluorescent probes for detection of metal ions, inorganic anions, small biomolecules, proteins, nucleic acids, drug molecules, pH, and temperature. We also summarize the usage of metal NCs in cellular and in vivo targeting and imaging. Finally, we conclude with a brief look at the future challenges and prospects of the development of AuNCs.

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Gold Nanocluster Embedded Albumin Nanoparticles for Two‐Photon Imaging of Cancer Cells Accompanying Drug Delivery

Cited by 139 publications

References 42 publications

Albumin nanostructures as advanced drug delivery systems

Albumin nanostructures as advanced drug delivery systems

Protein-gold clusters-capped mesoporous silica nanoparticles for high drug loading, autonomous gemcitabine/doxorubicin co-delivery, and in-vivo tumor imaging

Fluorescent Gold Nanoclusters: Promising Fluorescent Probes for Sensors and Bioimaging

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