Gold Nanocages:  Bioconjugation and Their Potential Use as Optical Imaging Contrast Agents

Chen, Jingyi; Saeki, Fusayo; Wiley, Benjamin J.; Cang, Hu; Cobb, Michael J.; Li, Zhi Yuan; Au, Leslie; Zhang, Hui; Kimmey, Michael B.; Li, Xingde; Xia, Younan

doi:10.1021/nl047950t

Cited by 929 publications

(682 citation statements)

References 24 publications

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“…(B) A fluorescence image of SK-BR-3 cells whose surfaces were treated with the anti-HER2 antibodies, followed by incubation with fluorescence-labeled IgG. Reproduced with permission from [27]. Copyright 2005 American Chemical Society).…”

Section: Discussionmentioning

confidence: 99%

“…To demonstrate this technique, we functionalized Au nanocages with tumor-specific antibodies. [27] Specifically, a breast-cancer cell line SK-BR-3 which over expresses epidermal growth factor receptor 2 (EGFR2 or HER2) was used to test the specificity. In a typical procedure, the primary antibody (monoclonal anti-HER2) was immobilized on the cancer cells by incubating the SK-BR-3 cells in a buffered anti-HER2 antibody solution.…”

Section: Bioconjugation Of Au Nanocagesmentioning

confidence: 99%

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Gold Nanocages for Biomedical Applications

et al. 2007

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Nanostructured materials provide a promising platform for early cancer detection and treatment.Here we highlight recent advances in the synthesis and use of Au nanocages for such biomedical applications. Gold nanocages represent a novel class of nanostructures, which can be prepared via a remarkably simple route based on the galvanic replacement reaction between Ag nanocubes and HAuCl 4 . The Au nanocages have a tunable surface plasmon resonance peak that extends into the near-infrared, where the optical attenuation caused by blood and soft tissue is essentially negligible. They are also biocompatible and present a well-established surface for easy functionalization. We have tailored the scattering and absorption cross-sections of Au nanocages for use in optical coherence tomography and photothermal treatment, respectively. Our preliminary studies show greatly improved spectroscopic image contrast for tissue phantoms containing Au nanocages. Our most recent results also demonstrate the photothermal destruction of breast cancer cells in vitro by using immuno-targeted Au nanocages as an effective photo-thermal transducer. These experiments suggest that Au nanocages may be a new class of nanometer-sized agents for cancer diagnosis and therapy.

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Section: Discussionmentioning

confidence: 99%

Section: Bioconjugation Of Au Nanocagesmentioning

confidence: 99%

Gold Nanocages for Biomedical Applications

et al. 2007

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“…For example, Braun et al utilized a 40 nm diameter hollow gold nanosphere with a 3 nm shell to temporally and spatially control cellular delivery of RNAi for gene silencing through a direct endosome release mechanism activated by pulsed laser [79]. RNAi desorption from the HGN, which is known to be initiated by cleavage of the Au-S bond, was monitored through Cyanine 3 (Cy3) fluorescence, which is partially quenched when attached to HGNs and unquenched when not associated [79,258,259]. In another study, Wu et al used HGNs as "nanosonicators" to trigger the release of a dye from inside liposomes in a proof of concept study demonstrating near instantaneous release of liposome contents with precise spatial and temporal control in vitro [257].…”

Section: Photothermal Transfectionmentioning

confidence: 99%

Controllable Cobalt Oxide/Au Hierarchically Nanostructured Electrode for Nonenzymatic Glucose Sensing

2016

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By electrodeposition and galvanic replacement reaction, we developed a facile, time-saving, cost-effective, and environmentally friendly, two-step synthesis route to obtain a controllable cobalt oxide/Au hierarchically nanostructured electrode for glucose sensing. The nanomaterials were characterized by transmission electron microscopy, scanning electron microscopy, Raman spectroscopy, energy-dispersive spectrometry, and X-ray photoelectron spectroscopy, meanwhile, the sensing performance was investigated by cyclic voltammetry and amperometric response. The results revealed that this novel electrode exhibited excellent electrocatalytic performance toward glucose oxidation, with a wide double-linear range from 0.2 μM to 20 mM and a low detection limit of 0.1 μM based on a signal-to-noise ratio of 3, which was mainly attributed to the ability of loading a small amount of Au with good electron conductivity on the surface of cobalt oxide nanosheets with large active surface area and synergistic electrocatalytic activity of Au and cobalt oxide toward glucose electrooxidation. This facile, sensitive, and selective glucose sensor is also proven to be suitable for the detection of glucose in human serum.

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“…[1,2] Among the other metals, silver is particularly attractive because of its significantly wide spread applications in optics, [3] electronics, [4] biology, [5] and catalysis. [6] In particular, its application in catalysis is important since it often combines the characteristics of high reactivity and selectivity.…”

Section: Introductionmentioning

confidence: 99%

Glycidyl‐Methacrylate‐Based Electrospun Mats and Catalytic Silver Nanoparticles

Demir

Uǧur

Gülgün

et al. 2008

Macro Chemistry & Physics

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P(AN‐GMA) and PGMA fibers coated with monodisperse silver nanoparticles have been prepared by a combination of electrospinning and electroless plating. The morphology of the electrospun fibers remains unchanged after surface hydrazination. Oxidation of hydrazine in an ammoniacal solution of AgNO3 reduces and deposits silver atoms along the fiber surface, which then coalesce to Ag particles. The size of the silver nanoparticles is varied between 20–60 nm. Since the density of the active sites for silver reduction is lower in P(AN‐GMA), a smaller particle size could be obtained. The catalytic activity of the silver nanoparticles has been confirmed.magnified image

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Gold Nanocages: Bioconjugation and Their Potential Use as Optical Imaging Contrast Agents

Cited by 929 publications

References 24 publications

Gold Nanocages for Biomedical Applications

Gold Nanocages for Biomedical Applications

Controllable Cobalt Oxide/Au Hierarchically Nanostructured Electrode for Nonenzymatic Glucose Sensing

Glycidyl‐Methacrylate‐Based Electrospun Mats and Catalytic Silver Nanoparticles

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