Gold nano particles synthesized from
            <i>Strychni semen</i>
            and its anticancer activity in cholangiocarcinoma cell (KMCH-1)

Li, Yuehua; Yang, Ke; Zou, Hao; Wang, Kun; Huang, Songquan; Rengarajan, Thamaraiselvan; Wang, Lin

doi:10.1080/21691401.2019.1594860

Cited by 16 publications

(3 citation statements)

References 42 publications

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“…Possible molecular mechanisms of these herbs and/or isolated compounds/synthetic analogs on CCA cells involve induction of apoptosis, autophagy, and cell cycle arrest (at G 0 /G 1 , G 1 , G 1 /S, or G 2 /M phases) through suppression of proinflammatory cytokines and growth factors (IL6, EGF, VEGF, etc.) 10 , 13 , 23 , 27 , 28 , 29 , 30 , 32 , 34 , 36 , 41 , 43 , 46 , 51 , 52 , 53 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 , 69 , 70 , 71 , 72 , 73 , 74 , 75 , 76 , 77 , 78 , 79 , 80 , 81 , 82 , 83 , 84 , 85 , suppression of expression of cell surface receptors ( Vegfr2 , EGFR peroxisome proliferator-activated receptor gamma, DR4 and DR5, and TRAIL) 69 , 86 , 87 , 88 , and deregulation of intracellular pathways (JAK/STAT3, RAS/MAPK, PI3K/AKT, GSK β / β -catenin, NF κ B/AMPK, ERK, p38/MAPK, HO1, ROS/JNK, EGFR, VEGF, COX2, FAK, MMP2, MMP9, ICAM1, caspase-3, -8, and − 9, TR1, MDR1, MRP1, 2, and 3, TRAF1, XIAP, p21, p53, p65, and CHOP dependent) ( Fig. 2 ) 7 , 11 , 16 , 19 ,…”

Section: Resultsmentioning

confidence: 99%

The Role of Herbal Medicine in Cholangiocarcinoma Control: A Systematic Review

2022

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The growing incidence of cholangiocarcinoma (bile duct cancer) and limited treatment options stimulate a pressing demand for research and the development of new chemotherapeutics against cholangiocarcinoma. This study aimed to systematically review herbs and herb-derived compounds or herbal formulations that have been investigated for their anti-cholangiocarcinoma potential. Systematic literature searches were conducted in three electronic databases: PubMed, ScienceDirect, and Scopus. One hundred and twenty-three research articles fulfilled the eligibility critera and were included in the analysis (68 herbs, isolated compounds and/or synthetic analogs, 9 herbal formulations, and 119 compounds that are commonly found in several plant species). The most investigated herbs were Atractylodes lancea (Thunb.) DC. (Compositae) and Curcuma longa L. (Zingiberaceae). Only A. lancea (Thunb.) DC. (Compositae) has undergone the full process of nonclinical and clinical development to deliver the final product for clinical use. The extracts of A. lancea (Thunb.) DC. (Compositae), Garcinia hanburyi Hook.f. (Clusiaceae), and Piper nigrum L. (Piperaceae) exhibit antiproliferative activities against human cholangiocarcinoma cells (IC50 < 15 µg/mL). Cucurbitacin B and triptolide are herbal isolated compounds that exhibit the most promising activities (IC50 < 1 µM). A series of experimental studies (in vitro, in vivo, and humans) confirmed the anti-cholangiocarcinoma potential and safety profile of A. lancea (Thunb.) DC. (Compositae) and its active compounds atractylodin and β-eudesmol, including the capsule pharmaceutical of the standardized A. lancea (Thunb.) DC. (Compositae) extract. Future research should be focused on the full development of the candidate herbs to deliver products that are safe and effective for cholangiocarcinoma control.

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Section: Resultsmentioning

confidence: 99%

The Role of Herbal Medicine in Cholangiocarcinoma Control: A Systematic Review

2022

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“…Caspases are a family of protease enzymes, which play major roles in the events of apoptosis. Specifically, the initiators caspase-8 and caspase-9 trigger the executioner caspase-3 by cleavage activation, leading to the proteolysis of poly(ADP-ribose) polymerase (PARP) and apoptosis through impairment of DNA repair [13]. Here, we show that treatment of HepG2 cells with gold nanoparticles with C. militaris extract induced caspase-3 activation to enhance apoptosis.…”

Section: Introductionmentioning

confidence: 85%

Green synthesis of gold nanoparticles using a Cordyceps militaris extract and their antiproliferative effect in liver cancer cells (HepG2)

Yang

Song

2019

Artificial Cells, Nanomedicine, and Biotechnology

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“…The chemical components of SS are complex and diverse, that mainly including alkaloids, phenolic acids, terpenoids, steroids and glycosides 9 – 13 . Modern pharmacological studies showed that SS has significant pharmacological effects in anti-tumor 14 , anti-rheumatism 15 , analgesia 16 , neuroprotection 17 and other diseases. SS contains a variety of monomers and acts on a variety of cell targets.…”

Section: Introductionmentioning

confidence: 99%

Systematic pharmacology-based strategy to explore the mechanism of Semen Strychni for treatment of papillary thyroid carcinoma

Mao,

Tang,

Fang

et al. 2023

Sci Rep

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The aim of the study was to investigated the mechanism of Strychnos nux-vomica L. (Semen Strychni, SS) against papillary carcinoma thyroid (PTC) by combined of network pharmacology and experimental verification. By searching the TCMSP, SEA and SwissTarget Prediction database, the main active ingredients and related targets were obtained. Utilizing Venny 2.1.0 String database and Cytoscape 3.7.2 to screened the intersection target and constructed protein–protein interaction (PPI) network diagram. Using R 4.0.4 software carried out the enrichment analysis of GO and KEGG. HPLC was carried out using LC-20A modular HPLC system to identify the bioactive compound brucine present in SS. Molecular docking was performed using Discovery 2019 software. The inhibition rate was detected by CCK8 method. Western blot was used to detect the expression levels of brucine anti-PTC related pathway proteins. 14 active components were screened out, of which 4 main components showed tight relationship with PTC. SS may play the anti-PTC role by acting on two main pathways (TNF signaling pathway and MAPK signaling pathway) and mediating various biological functions. HPLC analysis revealed that brucine was a suitable marker for standardization of the SS. 4 active components exhibit strong binding energy with core protein. Brucine could significantly reduce the activity of BCPAP cells compared with isobrucine, stigmasterol, (+)-catechin. Brucine may reduce the protein expression levels of IL-6, VEGFA, JUN, TP53, 1L1B, PTGS2, BCL2, CASP3, CASP8, and CASP9 while increase the protein expression levels of BAD, cleaved-CASP3, cleaved-CASP8, and cleaved-CASP9 in BCPAP cells, respectively. The active components of SS against PTC mainly include isobrucine, stigmasterol, (+)-catechin, brucine. Among them, brucine exhibits the strongest anti-PTC activity in BCPAP cells, which may reduce the PTC-related protein expression levels. Therefore, SS may exhibits the anti-PTC activities through multiple targets and pathways.

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Gold nano particles synthesized from Strychni semen and its anticancer activity in cholangiocarcinoma cell (KMCH-1)

Abstract: View related articles View Crossmark data Citing articles: 2 View citing articles Gold nano particles synthesized from Strychni semen and its anticancer activity in cholangiocarcinoma cell (KMCH-1

Cited by 16 publications

References 42 publications

The Role of Herbal Medicine in Cholangiocarcinoma Control: A Systematic Review

The Role of Herbal Medicine in Cholangiocarcinoma Control: A Systematic Review

Green synthesis of gold nanoparticles using a Cordyceps militaris extract and their antiproliferative effect in liver cancer cells (HepG2)

Systematic pharmacology-based strategy to explore the mechanism of Semen Strychni for treatment of papillary thyroid carcinoma

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