Gold micro‐particles for knee osteoarthritis

Rasmussen, Sten; Petersen, Kristian Kjær; Kristiansen, Martin Kaae; Skallerup, Jakob; Aboo, Christopher; Thomsen, Mikkel Eggert; Skjoldemose, Emilie; Jørgensen, Nia Kristine; Stensballe, Allan; Arendt-Nielsen, Lars

doi:10.1002/ejp.1909

Cited by 10 publications

(20 citation statements)

References 57 publications

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“…No SAE was reported. Another clinical study showed that intra-articular gold microparticles injection in knee osteoarthritis joints relieved perceived pain of OA patients [ 14 ]. The results from these two clinical studies in OA patients are consistent with the results from the present study in both RA and OA patients.…”

Section: Discussionmentioning

confidence: 99%

“…In a recent open-label study with 63 osteoarthritis (OA) patients, intra-articular gold injection improved their Knee injury and Osteoarthritis Outcome Score (KOOS) and Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) scores, with no reported severe adverse effects (SAE) [ 13 ]. In another newly published exploratory clinical study, gold microparticles injected intra-articularly in osteoarthritic knee joints relieved perceived pain and generated an inflammation modulatory effect based on proteome changes found in synovial fluid SF and serum [ 14 ].…”

Section: Introductionmentioning

confidence: 99%

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A Clinical Study to Evaluate the Safety and Efficacy of Oral Administration of Microscopic Dose Gold Nanoparticle (AuNP) on Knee Joint Health and Function in Arthritis Patients

Han¹,

Avelar²,

Mathai³

et al. 2022

JFMK

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The purpose of this clinical study was to determine whether gold nanoparticle (AuNP) supplementation at a dosage of 0.17 mg elemental gold per day can improve knee joint health, function, and quality of life for arthritis patients. A total of 51 participants (24 male and 27 female, age 62.1 ± 13.1) were followed for 20 weeks through a three-phase longitudinal study. Both subjective and objective parameters were used to measure changes in joint health and function, as well as quality of life. The study found patients’ Knee injury and Osteoarthritis Outcome Score (KOOS) improved with statistical significance. It was reported that 71.42% of the cohort experienced improvements in their perceived knee pain and 61.22% with improvements in knee stiffness. Majority of objective measurements such as pain with range of motion and specific exercises requiring proper knee health and function did not show statistically significant improvement but did show a positive improving trend in support of AuNP supplement. Study cohort showed statistically significant improvements in two specific exercises: sit-to-stand and single-leg squat. By the end of the study, 70% of the study cohort indicated that they would continue to take the supplement even after the study concluded. Though the study has limitations and is not definitely conclusive, it was the first clinical study to show that oral micro-dosage of AuNP as low as 0.17 mg daily is safe and effective for both rheumatoid arthritis and osteoarthritis patients. This study opened way for the use of AuNP in both clinical and daily settings to improve joint health and function for both average and athletic users.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

A Clinical Study to Evaluate the Safety and Efficacy of Oral Administration of Microscopic Dose Gold Nanoparticle (AuNP) on Knee Joint Health and Function in Arthritis Patients

Han¹,

Avelar²,

Mathai³

et al. 2022

JFMK

View full text Add to dashboard Cite

show abstract

“…Prior studies do support the role of inflammation in the pathogenesis of osteoarthritis including nodal osteoarthritis of the hand [9,10]. Injection of gold microparticles directly into osteoarthritic knee joints may provide pain relief and improved joint function [11]. The use of gold-based autologous conditioned serum injection into affected joints is now being explored as a treatment in osteoarthritis [12].…”

Section: Clinical Image Peer Reviewed | Open Accessmentioning

confidence: 99%

Gold wedding bands: Attenuation of Heberden’s nodal expression in osteoarthritis

Rabinovitch

Kravitz

2022

J Case Rep Images Med

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“…We evaluated pain and function at baseline and at a two-year follow in two groups of patients with painful KOA. One group, I, received intra-articular 20 mg gold micro-particles using the patient's synovial uid (SF) as the carrier [4]. The other group, II, received intra-articular 20 mg gold micro-particles using hyaluronic acid (HA) as the carrier.…”

Section: Study Owmentioning

confidence: 99%

“…During the inclusion of our open pilot study, we excluded a larger group of KOA patients due to multisite pain, co-morbidities, and other exclusion criteria [4]. This group received intra-articular gold microparticles using hyaluronic acid, whereas the included group received the treatment using the patient's synovial uid.…”

Section: Introductionmentioning

confidence: 99%

Intra-articular injection of gold micro-particles for painful knee osteoarthritis

Rasmussen

Petersen

Aboo

et al. 2022

Preprint

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Background: Gold microparticles injected intra-articular in knee osteoarthritic joints (OA) may provide pain relief. The present open, exploratory study sought to identify the efficacy and factors associated with the outcomes. Methods: This study included thirty patients with knee OA who received intraarticular injections with 20 mg gold microparticles (72.000 particles, 20–40 µm in diameter) using the patient’s synovial fluid as the carrier, and 136 patients with knee OA who received 20 mg gold microparticles using hyaluronic acid as the carrier. In the analysis, we included the Global Rating of Change Scale, PainDetectQuestionnaire (PDQ), the use of a carrier, Body Mass Index (BMI), and Kellgren Lawrence score at the inclusion, Western Ontario, and McMaster Universities Osteoarthritis Index (WOMAC) sub-scores for pain, stiffness, and function at inclusion and two years. Results: On the Global Rating Change Scale, 72.9% of patients reported a positive effect, 23.5% no effect, and 2.4% worse. PDQ and the three WOMAC subscores all improved at two years of follow-up. The use of carrier did not influence the effect at two years of follow-ups corrected for the other selected co-variables (P = 0.36). PainDetect ≥ 13 (P = 0.0027), BMI (P = 0.008) and Kellgren-Lawrence grade 4 (P = 0.049) at inclusion reduced the effect with a minor odds ratio compared to the baseline effect of treatment (P = 0.03). WOMAC subscores at inclusion did not influence the effect (P > 0.5). Conclusions: A single intra-articular injection of gold microparticles was associated with pain reduction and improved function in patients with knee OA. Neuropathic pain, obesity, and severe osteoarthritis, to a minor degree, reduced the effect of intra-articular gold microparticles for knee OA. Trial registration The study followed the principles of the Declaration of Helsinki and was approved by the local ethics committee of the North Denmark Region by 27/07/2016 (N-20160045). The regional data protection agency approved the project by 06/07/2016 (2008-58-0028, ID 2016-116) and registered in ClinicalTrial.Gov by 04/01/2018 (NCT03389906).

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Gold micro‐particles for knee osteoarthritis

Abstract: This is an open access article under the terms of the Creat ive Commo ns Attri butio n-NonCo mmerc ial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

Cited by 10 publications

References 57 publications

A Clinical Study to Evaluate the Safety and Efficacy of Oral Administration of Microscopic Dose Gold Nanoparticle (AuNP) on Knee Joint Health and Function in Arthritis Patients

A Clinical Study to Evaluate the Safety and Efficacy of Oral Administration of Microscopic Dose Gold Nanoparticle (AuNP) on Knee Joint Health and Function in Arthritis Patients

Gold wedding bands: Attenuation of Heberden’s nodal expression in osteoarthritis

Intra-articular injection of gold micro-particles for painful knee osteoarthritis

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