Gold-Loaded Nanoporous Ferric Oxide Nanocubes with Peroxidase-Mimicking Activity for Electrocatalytic and Colorimetric Detection of Autoantibody

Masud, Mostafa Kamal; Yadav, Sharda; Islam, Md. Nazmul; Nguyen, Nam‐Trung; Salomón, Carlos; Kline, Richard; Alamri, Hatem R.; ALOthman, Zeid A.; Yamauchi, Yusuke; Hossain, Md. Shahriar A.; Shiddiky, Muhammad J. A.

doi:10.1021/acs.analchem.7b02880

Cited by 138 publications

(143 citation statements)

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“…In other report, Masud et al reported the significant enhancement in catalytic properties of porous Fe 2 O 3 nanocubes for TMB oxidation through the loading of Au NPs. This enhancement was attributed to the provision of a larger contact area to promote improved interaction with the positively charged TMB.…”

Section: Functional Applications Of Iron Oxide‐based Nanoarchitecturesmentioning

confidence: 92%

A Review on Iron Oxide‐Based Nanoarchitectures for Biomedical, Energy Storage, and Environmental Applications

et al. 2019

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Iron oxide nanoarchitectures with distinct morphologies from 1D to 3D have been developed using various wet chemical methods. They have been employed for a wide range of applications, including energy storage, biomedical, and environmental applications. The functional properties of iron oxide nanoarchitectures depend on the size, shape, composition, magnetic properties, and surface modification. To overcome the limitations of pure iron oxide nanostructures, hybridizations with various inorganic materials (e.g., silica, metals, metal oxides) and carbon‐based materials have been proposed. Herein, the recent advances in the preparation of various iron oxide nanoarchitectures are reviewed along with their functional applications in energy storage, biomedical, and environmental fields. Finally, the effects of various parameters on the functional performance of iron oxide nanostructures for these applications are summarized and the trends and future outlook on the development of iron oxide nanoarchitectures for these applications are also given.

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Section: Functional Applications Of Iron Oxide‐based Nanoarchitecturesmentioning

confidence: 92%

A Review on Iron Oxide‐Based Nanoarchitectures for Biomedical, Energy Storage, and Environmental Applications

et al. 2019

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“…This reaction has been widely used to design sensitive biosensors for detecting hydrogen peroxide, glucose, cells, and disease‐specific biomolecules ,,,. Recently, we have reported the synthesis and peroxidase mimetic activity of gold‐loaded nanoporous iron oxide materials for colorimetric and electrochemical detection of cancer biomarker, p53 autoantibody . Herein, we have elaborately studied the mechanism involved in the peroxidase mimetics of four different engineered IONF samples and compared their performance to obtain the optimum nanozyme for future biosensing.…”

Section: Resultsmentioning

confidence: 99%

“…More importantly, the IONF_250 sample exhibited a much higher absorbance compared to the control sample by almost 13‐fold (0.546 versus 0.042) at 652 nm (Figure b). The possible mechanism for IONFs‐induced peroxidase mimetics could be due to the ferric ions (Fe 3+ ) (from IONFs) initiating the oxidation of TMB by generating hydroxyl free radical (⋅OH) from H 2 O 2 following the Fenton reaction, as shown in Equations (i) to (iv)

true Fe^{3 +} + normalH_{2} normalO_{2} \to FeOOH^{2 +} + normalH^{+}

true FeOOH^{2 +} \to Fe^{2 +} + HO_{2 •}

true Fe^{2 +} + normalH_{2} normalO_{2} \to Fe^{3 +} + OH^{-} +^{•} OH

true^{•} OH + TMB_{(colourless)} \to TMB_{ox (blue)}

…”

Section: Resultsmentioning

confidence: 99%

“…As a result, they have been exploited for the development of novel assays for the detection of a wide range of chemicals and biomolecules . The iron oxide peroxidase mimetics are highly attractive over natural enzyme horseradish peroxidase (HRP) owing to their higher stability towards the denaturation or protease digestion, inexpensive and easy synthesis and engineered substrate binding pockets for specific molecular recognition ,. However, many previously reported iron oxide materials only demonstrated peroxidase mimetics at higher temperatures (35–45 °C), which is unfavorable for room‐temperature biosensing applications .…”

Section: Introductionmentioning

confidence: 99%

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Enhanced Peroxidase Mimetic Activity of Porous Iron Oxide Nanoflakes

et al. 2019

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Porous nanomaterials with superior peroxidase mimetic activity (nanozyme) at room temperature have gained increasing attention as potential alternatives to natural peroxidase enzymes. Herein, we report the application of porous iron oxide nanoflakes (IONFs), synthesized using the combination of solvothermal method and high-temperature calcination as peroxidase nanozyme for the oxidation of 3,3',5,5'-tetramethylbenzidine (TMB) in the presence of H 2 O 2 . The four IONF catalysts possess porous structures with a wide pore size distribution between 2-30 nm and high specific surface areas around to 200 m 2 g À1 . The increase of calcination temperature of the IONFs from 250 8C to 400 8C resulted in a gradual decrease in their specific surface area and Michaelis-Menten constant (K m ) for TMB oxidation. The optimum IONF sample showed a much lower K m at 0.24 mM (towards TMB) compared to natural enzyme horseradish peroxidase (HRP) at 0.434 mM, revealing the promising potential of the asprepared IONFs as alternatives to HRP for biosensing applications.[a] Dr.

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“…A peroxidase-mimetic nanomaterials-based sensor was demonstrated recently (Figure 8b) [63]. The recognition element was the antigen attached to the carbon electrode.…”

Section: Sensitive Detection Strategymentioning

confidence: 96%

Recent Developments of Electrochemical and Optical Biosensors for Antibody Detection

Wang

et al. 2019

IJMS

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Detection of biomarkers has raised much interest recently due to the need for disease diagnosis and personalized medicine in future point-of-care systems. Among various biomarkers, antibodies are an important type of detection target due to their potential for indicating disease progression stage and the efficiency of therapeutic antibody drug treatment. In this review, electrochemical and optical detection of antibodies are discussed. Specifically, creating a non-label and reagent-free sensing platform and construction of an anti-fouling electrochemical surface for electrochemical detection are suggested. For optical transduction, a rapid and programmable platform for antibody detection using a DNA-based beacon is suggested as well as the use of bioluminescence resonance energy transfer (BRET) switch for low cost antibody detection. These sensing strategies have demonstrated their potential for resolving current challenges in antibody detection such as high selectivity, low operation cost, simple detection procedures, rapid detection, and low-fouling detection. This review provides a general update for recent developments in antibody detection strategies and potential solutions for future clinical point-of-care systems.

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Gold-Loaded Nanoporous Ferric Oxide Nanocubes with Peroxidase-Mimicking Activity for Electrocatalytic and Colorimetric Detection of Autoantibody

Cited by 138 publications

References 51 publications

A Review on Iron Oxide‐Based Nanoarchitectures for Biomedical, Energy Storage, and Environmental Applications

A Review on Iron Oxide‐Based Nanoarchitectures for Biomedical, Energy Storage, and Environmental Applications

Enhanced Peroxidase Mimetic Activity of Porous Iron Oxide Nanoflakes

Recent Developments of Electrochemical and Optical Biosensors for Antibody Detection

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