Gold(III) chloride (HAuCl4·3H2O) in PEG: A new and efficient catalytic system for the synthesis of functionalized spirochromenes

Kidwai, Mazaahir; Jahan, Anwar; Mishra, Neeraj Kumar

doi:10.1016/j.apcata.2012.02.043

Cited by 42 publications

(13 citation statements)

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“…The Kidwai group developed a protocol for the efficient synthesis of functionalized spirochromenes 50 and 51 mediated by a gold(III) catalyst [ 93 ]. They used PEG 400 as it is an eco-friendly solvent medium, being inexpensive, thermally stable, recyclable and biodegradable ( Scheme 15 and Scheme 16 ) [ 94 ]. Several parameters were explored in order to optimize the processes.…”

Section: Gold-catalyzed Multicomponent Reactionsmentioning

confidence: 99%

Gold Catalyzed Multicomponent Reactions beyond A3 Coupling

et al. 2018

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The preparation of complex architectures has inspired the search for new methods and new processes in organic synthesis. Multicomponent reactions have become an interesting approach to achieve such molecular diversity and complexity. This review intends to illustrate important gold-catalyzed examples for the past ten years leading to interesting skeletons involved in biologically active compounds.

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Section: Gold-catalyzed Multicomponent Reactionsmentioning

confidence: 99%

Gold Catalyzed Multicomponent Reactions beyond A3 Coupling

et al. 2018

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“…A number of methods have been developed for the synthesis of such compounds and the chemistry was comprehensively reviewed by several groups [12,13,19,[31][32][33][34][35][36][37][38].…”

Section: Introductionmentioning

confidence: 99%

Caspian Isinglass, a versatile and sustainable biocatalyst for domino synthesis of spirooxindoles and spiroacenaphthylenes in water

et al. 2016

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Isinglass, derived from swim bladders of Caspian Sea fish and consisting predominantly of protein collagen, was found to be an effective, easily accessible heterogeneous biocatalyst for the synthesis of biologically important functionalized spirooxindoles and spiroacenaphthylenes in water. This facile and efficient one-pot, three-component synthesis route involving isatin or acenaphthenequinone, activated methylene reagent, and 1,3-dicarbonyl compounds provides a new strategy giving rise to spiro derivatives in quantitative yields in very short reaction times. Graphical abstract N CN X O O R 2 R 1 N O X H2N R 2 R 1 O O O O H2O, 60 °C H2O, 60 °C O O O O X H2N O 6 2 3 4 5 1 X= CN, CO2Et R 1 = H, Me, Et, Bn, Ph R 2 = H, Cl, Br, NO2 IG IG

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“…These compounds are acknowledged for display of various biological activities like anti‐HIV, antitumor, antitubercular, antimalarial, and central nervous system (CNS) activities and effects . Therefore, different catalysts have been used to synthesize these spirooxindole scaffolds such as alum, l ‐proline, Caspian Isinglass, borax, and gold (III) chloride . Although such protocols reported by others find certain merits of their own.…”

Section: Introductionmentioning

confidence: 99%