Gold(I) Nitrogen Chemistry

Abdou, Hanan E.; Mohamed, Ahmed A.; Fackler, John P.

doi:10.1002/9783527626724.ch1

Cited by 21 publications

(23 citation statements)

References 81 publications

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“…Thiol molecules are chemisorbed on Au by strong thiolate-Au bonds (40-50 kcal mol −1 ) compared to NH 2 forming weak covalent binding with Au-N bond strengths estimated to be 8 kcal mol −1 [49,50]. It is suggested that all three peptides bind to the AuNP surface via the free thiol of the cysteine residues [51,52]. This binding was observed be optimized by adjusting the pH to 8 which results in the protonation of the thiol group.…”

Section: Discussionmentioning

confidence: 99%

Peptide functionalized gold nanoparticles: the influence of pH on binding efficiency

Harrison¹,

Hamilton²,

Macías-Montero³

et al. 2017

Nanotechnology

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We report herein on the synthesis of mixed monolayer gold nanoparticles (AuNPs) capped with both polyethylene glycol (PEG) and one of three peptides. Either a receptor-mediated endocytosis peptide, an endosomal escape pathway (H5WYG) peptide or the Nrp-1 targeting RGD peptide (CRGDK) labeled with FITC. All three peptides have a thiol containing cysteine residue which can be used to bind the peptides to the AuNPs. In order to investigate the influence of pH on peptide attachment, PEGylated AuNPs were centrifuged, the supernatant removed, and the nanoparticles were then re-suspended in a range of pH buffer solutions above, below and at the respective isoelectric points of the peptides before co-functionalization. Peptide attachment was investigated using dynamic light scattering, Ultra-violet visible spectroscopy (UV/Vis), FTIR and photo luminescence spectroscopy. UV/Vis analysis coupled with protein assay results and photoluminescence of the FITC tagged RGD peptide concluded that a pH of ∼8 optimized the cysteine binding and stability, irrespective of the peptide used.

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Section: Discussionmentioning

confidence: 99%

Peptide functionalized gold nanoparticles: the influence of pH on binding efficiency

Harrison¹,

Hamilton²,

Macías-Montero³

et al. 2017

Nanotechnology

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“…Recently, spontaneous occurrence of anti-idiotypic antibodies in human diseases has been described in myasthaenia gravis by us [9. IU] and others [3] and in systemic lupus erythematosus [1], In this regard, the reccptor-likf properties of our monoclonal anti-idiotype are of special interest. The role of anti-idiotypic antibodies in myasthenia may thus be twofold: protection from the damaging effects of the receptor antibody by inhibition of its binding to receptor, and the reverse: stimulation of the production of receptor antibodies, leading to persistence of antibody synthesis (16,20].…”

Section: Discussionmentioning

confidence: 99%

Receptor‐like Activity of a Monoclonal Anti‐Idiotypic Antibody against an Anti Acetylcholine Receptor Antibody

Lefvert

Fulpius

1984

Scand J Immunol

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A monoclonal anti-idiotypic antibody against an anti-acetylcholine receptor antibody from a patient with myasthenia gravis was shown to bind the cholinergic ligand alpha-bungarotoxin. This binding could be inhibited by other cholinergic ligands, both antagonists and agonists. The anti-idiotype was also able to elicit the production of anti-receptor antibodies in mice. Thus, the anti-idiotype had functional properties similar to those of the original antigen, the acetylcholine receptor.

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“…Red crystals suitable for X-ray diffraction analysis were obtained by heating a saturated THF solution and slowly cooling to room temperature. 1 …”

Section: Synthesis Of Au2[cs2(26-me2c6h3nc(h)=nc6h3me2)]2mentioning

confidence: 99%

“…Hence, gold-nitrogen bonds are uncommon [1] and the reactivity of these bonds is relatively unexplored [2]. With the recent advances in gold amidinate chemistry [3], we sought to develop this reactivity by examining insertion and oxidative chemistry in Au(I) amidinate complexes.…”

Section: Introductionmentioning

confidence: 99%

“…The oxidative chemistry of dinuclear Au(I) amidinate complexes is characterized by a two-electron redox process with one-electron being produced from each Au(I) center to create Au(II,II) amidinate complexes, and maintains its dinuclear core. For example, reactions of PhICl2, Br2, and I2 with Au2[(2,6-Me2C6H3N)2C(H)]2 produce Au2[(2,6-Me2C6H3N)2C(H)]2(X)2, X = Cl, Br, and I [5], respectively, Equation (1). (1) While the redox chemistry of these species has been observed, no insertion chemistry has been explored which affords the opportunity to expand to polymetallic complexes.…”

Section: Introductionmentioning

confidence: 99%

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Reactivity of Mononuclear and Dinuclear Gold(I) Amidinate Complexes with CS2 and CsBr3

et al. 2014

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Gold(I) Nitrogen Chemistry

Cited by 21 publications

References 81 publications

Peptide functionalized gold nanoparticles: the influence of pH on binding efficiency

Peptide functionalized gold nanoparticles: the influence of pH on binding efficiency

Receptor‐like Activity of a Monoclonal Anti‐Idiotypic Antibody against an Anti Acetylcholine Receptor Antibody

Reactivity of Mononuclear and Dinuclear Gold(I) Amidinate Complexes with CS2 and CsBr3

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