Gold(I)-Catalyzed Asymmetric Aldol Reaction of N-Methoxy-N-methyl-.alpha.-isocyanoacetamide (.alpha.-Isocyano Weinreb Amide). An Efficient Synthesis of Optically Active .beta.-Hydroxy .alpha.-Amino Aldehydes and Ketones

Sawamura, Masaya; Nakayama, Yuki; Kato, Tomoki; Ito, Yoshihiko

doi:10.1021/jo00111a034

Cited by 118 publications

(49 citation statements)

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“…This may provide new opportunities in organic chemistry using gold as a catalyst. In 1986, the Ito-Hayashi asymmetric aldol reaction catalyzed by homogeneous gold was successfully reported for the first time (Sawamura et al, 1995). Thereafter, Fukuda and Utimoto, (1991) and Teles et al, (1998) as well as the Hashmi group (Hashmi et al, 2000) and others (Hayashi et al, 1992) initiated an impressive growth of activities on homogeneous gold catalysis.…”

Section: Catalytic Propertiesmentioning

confidence: 99%

Biopharmaceutical applications of nanogold

Alanazi

Radwan

Alsarra

2010

Saudi Pharmaceutical Journal

143

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The application of nanogold in biopharmaceutical field is reviewed in this work. The properties of nanogold including nanogold surface Plasmon absorption and nanogold surface Plasmon light scattering are illustrated. The physical, chemical, biosynthesis methods of nanogold preparation are presented. Catalytic properties as well as biomedical applications are highlighted as one of the most important applications of nanogold. Biosensing, and diagnostic and therapeutic applications of gold nanoparticles are evaluated. Moreover, gold nanoparticles in drugs, biomolecules and proteins' delivery are analyzed. Gold nanoparticles for the site-directed photothermal applications are reviewed as the most fruitful research area in the future.

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Section: Catalytic Propertiesmentioning

confidence: 99%

Biopharmaceutical applications of nanogold

Alanazi

Radwan

Alsarra

2010

Saudi Pharmaceutical Journal

143

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“…In addition, Ito and coworkers have also demonstrated the suitability of a-isocyano Weinreb amide for the aldol reaction with different aldehydes, which allowed facile access to the synthesis of optically active a-amino aldehydes [47].…”

Section: Applications Of Gold or Silver-catalyzed Asymmetric Aldol Rementioning

confidence: 99%

Unsymmetrical 1,1′‐Bidentate Ferrocenyl Ligands

You

2009

Chiral Ferrocenes in Asymmetric Catalysis

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This chapter focuses on the preparation of enantiopure 1,1 0 -unsymmetrically disubstituted ferrocenes and their applications in asymmetric catalysis. Notably, Gibson, Long, and coworkers have documented a comprehensive review on the synthesis and catalytic applications of unsymmetrical ferrocene ligands [1]. Enantiopure 1,1 0 -bidentate ferrocenyl ligands attracted much attention soon after the discovery of ferrocene, mainly due to their unique rigid binding mode and relatively straightforward synthesis. Even today, 1,1 0 -bidentate ferrocenes still serve as an important scaffold for the design of new chiral ligands. It should be noted that the symmetrical 1,1 0 -bidentate ferrocenyl ligands, a very important class of this family, are discussed in Chapter 7. In this chapter, in addition to those having two different substituents at the 1,1 0 -positions of ferrocene I, the scope of ferrocenyl ligands will also cover unsymmetrical ferrocenyl ligands bearing identical coordination groups at the 1,1 0 -positions of ferrocene (II), for example, L1a [(R,Sp)-BPPFA] (Figure 8.1).Due to the ready availability of BPPFA and its close analogs, they have been used for many catalytic asymmetric reactions. However, the corresponding work in which BPPFA and its close analogs were simply screened and unable to afford the optimal result will not be discussed in detail. This chapter will be divided into several parts based on the reaction type. Palladium-Catalyzed Asymmetric Allylic Substitution ReactionPalladium-catalyzed allylic substitution reactions have been used extensively in asymmetric carbon-carbon and carbon-heteroatom bonds formation to provide chemo-, regio-, diastereo-, and enantioselectivity [2]. The enantioselective version of this reaction has been demonstrated successfully in organic synthesis, including the Chiral Ferrocenes in Asymmetric Catalysis. Edited by Li-Xin Dai and Xue-Long Hou

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“…Cationic NCN-pincer palladium(II) aqua complexes can serve as catalyst in Lewis acid catalyzed aldol type reactions, such as the addition of methyl isocyanoacetate to benzaldehydes, to produce a diastereomeric mixture of oxazolines (Scheme 5) [34][35][36][37][38].…”

Section: Catalytic Activity In Aldol Condensationsmentioning

confidence: 99%