Gold(I) and silver(I) complexes of 2,3-bis(diphenylphosphino)maleic acid: Structural studies and antitumour activity

Targeting the mitochondrial cell death pathway with gold compounds

“…4) [79]. Interestingly, [Au(dpmaa) 2 ]Cl exhibited no significant cytotoxicity when assessed against eight different cancer lines [79]. The complex was shown to be stable after prolonged incubation in cell culture media containing 5% fetal calf serum and the lack of cytotoxicity maybe a reflection of a low degree of cellular uptake.…”

“…The bis-chelated 2:1 adduct of Au(I) with 2,3-bis(diphenylphosphino)maleic acid, [Au(dpmaa) 2 ]Cl (7; Scheme 2), is highly water soluble and the crystal structure shows a well defined hydrogen bond network involving the carboxyl groups (Fig. 4) [79]. Interestingly, [Au(dpmaa) 2 ]Cl exhibited no significant cytotoxicity when assessed against eight different cancer lines [79].…”

Anti-cancer potential of gold complexes

“…The cationic compounds related to (6) can be chemically modified to moderate their lipophilicity by substituting the phosphorus-bound phenyl groups with, for example, pyridyl groups (Berners-Price et al, 1999). Alternatively, the nature of the bridge between phosphorus atoms can be changed but these water-soluble derivatives are inactive (Berners-Price et al, 2005). A three-coordinate analogue, (14) (1)-(6).…”

Water‐Soluble (Phosphane)gold(I) Complexes – Applications as Recyclable Catalysts in a Three‐Component Coupling Reaction and as Antimicrobial and Anticancer Agents

“…[12] Some of the phosphanes used are depicted in figure 1. Sulfonated aryl phosphanes (abbreviated TPPMS, TPPDS, TPPTS), [13] mono o di-phosphanes containing pyridyl groups such as D n PYPE, D n PYPP [14] or maleic acid (DPMAA), [15] phosphanes like 1,3,5-triaza-7-phosphaneadamantane (TPA) or 3,7-diacetyl-1,3,7-triaza-5-phosphabicyclo[3.3.1] nonane (DAPTA) [16] have been employed in the preparation of gold compounds with simple halide ligands (Cl, Br) or other coordination/organometallic complexes with thiolato, thionato, or alkynyl ligands. More recently, phosphanes containing hydroxyl groups [17] and water-soluble cyclodiphosphazanes [18] have been employed in the preparation of gold(I) compounds.…”