Gold-Decorated Silicon Nanowire Photocatalysts for Intracellular Production of Hydrogen Peroxide

Phillips, Andrew W.; Parameswaran, Ramya; Lichter, Emma; Jeong, Junyoung; Meng, Lingyuan; Burke, Michael J.; Koehler, Kelliann; Lee, Youjin V.; Tian, Bozhi

doi:10.1021/acsami.0c23164

Cited by 6 publications

(4 citation statements)

References 89 publications

(159 reference statements)

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“…In just the past few years, a nascent field of faradaic delivery concepts for neuromodulation has begun to emerge. Recently, Tian and colleagues reported a photoactivated silicon/Au nanowire system for intracellular H 2 O 2 delivery, [ 34 ] suggesting this as a potent approach to enable novel experimental procedures to understand ROS effects. In pioneering works from Antognazza and coworkers, the photochemical production of peroxide/ROS by organic semiconductors, namely polythiophenes, was demonstrated at the level of several biological targets: charge‐transfer to redox proteins, [ 35 ] stimulation of transient‐receptor vanilloid subtype ion channels, [ 36 ] and ultimately control of stem cell differentiation.…”

Section: Introductionmentioning

confidence: 99%

Faradaic Pixels for Precise Hydrogen Peroxide Delivery to Control M‐Type Voltage‐Gated Potassium Channels

et al. 2021

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H2O2 plays a significant role in a range of physiological processes where it performs vital tasks in redox signaling. The sensitivity of many biological pathways to H2O2 opens up a unique direction in the development of bioelectronics devices to control levels of reactive‐oxygen species (ROS). Here a microfabricated ROS modulation device that relies on controlled faradaic reactions is presented. A concentric pixel arrangement of a peroxide‐evolving cathode surrounded by an anode ring which decomposes the peroxide, resulting in localized peroxide delivery is reported. The conducting polymer (poly(3,4‐ethylenedioxythiophene) (PEDOT), is exploited as the cathode. PEDOT selectively catalyzes the oxygen reduction reaction resulting in the production of hydrogen peroxide (H2O2). Using electrochemical and optical assays, combined with modeling, the performance of the devices is benchmarked. The concentric pixels generate tunable gradients of peroxide and oxygen concentrations. The faradaic devices are prototyped by modulating human H2O2‐sensitive Kv7.2/7.3 (M‐type) channels expressed in a single‐cell model (Xenopus laevis oocytes). The Kv7 ion channel family is responsible for regulating neuronal excitability in the heart, brain, and smooth muscles, making it an ideal platform for faradaic ROS stimulation. The results demonstrate the potential of PEDOT to act as an H2O2 delivery system, paving the way to ROS‐based organic bioelectronics.

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Section: Introductionmentioning

confidence: 99%

Faradaic Pixels for Precise Hydrogen Peroxide Delivery to Control M‐Type Voltage‐Gated Potassium Channels

et al. 2021

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“…Application of new material systems, such as a low-dimensional carbon-based composite, 42 , 43 can potentially improve modulation efficiency. Advances in nanostructure synthesis and further modification on the nanoscale and atomic scale are promising to yield more robust signal transduction interfaces, where biomechanical sensing by the cellular machinery 44 or biocatalysis 45 may play additional roles. We believe that many paradigms previously successfully applied in energy science and catalysis can be adapted to improve bioelectronic devices.…”

Section: Discussionmentioning

confidence: 99%

Nanoenabled Bioelectrical Modulation

Promiński

Miao

et al. 2021

Acc. Mater. Res.

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Conspectus Studying the formation and interactions between biological systems and artificial materials is significant for probing complex biophysical behaviors and addressing challenging biomedical problems. Bioelectrical interfaces, especially nanostructure-based, have improved compatibility with cells and tissues and enabled new approaches to biological modulation. In particular, free-standing and remotely activated bioelectrical devices demonstrate potential for precise biophysical investigation and efficient clinical therapies. Interacting with single cells or organelles requires devices of sufficiently small size for high resolution probing. Nanoscale semiconductors, given their diverse functionalities, are promising device platforms for subcellular modulation. Tissue-level modulation requires additional consideration regarding the device’s mechanical compliance for either conformal contact with the tissue surface or seamless three-dimensional (3D) biointegration. Flexible or even open-framework designs are essential in such methods. For chronic organ integration, the highest level of biocompatibility is required for both the materials and device configurations. Additionally, a scalable and high-throughput design is necessary to simultaneously interact with many individual cells in the organ. The physical, chemical, and mechanical stabilities of devices for organ implantation may be improved by ensuring matching of mechanical behavior at biointerfaces, including passivation or resistance designs to mitigate physiological impacts, or incorporating self-healing or adaptative properties. Recent research demonstrates principles of nanostructured material designs that can be used to improve biointerfaces. Nanoenabled extracellular interfaces were frequently used for either electrical or remote optical modulation of cells and tissues. In particular, methods are now available for designing and screening nanostructured silicon, especially chemical vapor deposition (CVD)-derived nanowires and two-dimensional (2D) nanostructured membranes, for biological modulation in vitro and in vivo. For intra- and intercellular biological modulation, semiconductor/cell composites have been created through the internalization of nanowires, and such cellular composites can even integrate with living tissues. This approach was demonstrated for both neuronal and cardiac modulation. At a different front, laser-derived nanocrystalline semiconductors showed electrochemical and photoelectrochemical activities, and they were used to modulate cells and organs. Recently, self-assembly of nanoscale building blocks enabled fabrication of efficient monolithic carbon-based electrodes for in vitro stimulation of cardiomyocytes, ex vivo stimulation of retinas and hearts, and in vivo stimulation of sciatic nerves. Future studies on nanoenabled bioelectrical modulation should focus on improving efficiency and stability of current and emerging technologies. New materials and devices can access new ...

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“…Such a film could also bring benefits in biological applications that require H 2 O 2 . Phillips et al demonstrated that Au-sputtered Si NW films produced 6.2 μM/cm 2 H 2 O 2 in 30 minutes in water under visible light and without any sacrificial agents suitable for intracellular H 2 O 2 production[63]. However, the exact mechanism requires further studies, but it is believed the gold-silicon interface is responsible for the production of H 2 O 2 .…”

mentioning

confidence: 99%

Gold photocatalysis in sustainable hydrogen peroxide generation

Adnan

Jalil

2022

Preprint

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Hydrogen peroxide (H2O2) is a mild and green oxidant widely employed in organic syntheses, medical sector, disinfection, bleaching, environmental remediation and biological processes. However, its production via the expensive, multiple steps and energy intensive anthraquinone process renders it less sustainable. Photocatalysis is a viable, sustainable and promising strategy to produce H2O2 from green sources: water and molecular O2. This article presents the key developments of photocatalytic H2O2 production using gold (Au) nanoparticles supported on semiconductor photocatalysts. Several photocatalytic systems containing Au nanoparticles and the roles of Au nanoparticles in enhancing the photocatalytic H2O2 production including increasing visible light absorption, facilitating the charge carrier separation and transfer, and as a catalytic Au active site are discussed. Factors defining the photocatalytic activity such as the effects of Au particle size and loading, localised surface plasmon resonance, mixed-gold component, and design of photocatalysts are reviewed. Finally, the challenges and prospect for further developments of Au photocatalysis in sustainable H2O2 synthesis are highlighted.

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Gold-Decorated Silicon Nanowire Photocatalysts for Intracellular Production of Hydrogen Peroxide

Cited by 6 publications

References 89 publications

Faradaic Pixels for Precise Hydrogen Peroxide Delivery to Control M‐Type Voltage‐Gated Potassium Channels

Faradaic Pixels for Precise Hydrogen Peroxide Delivery to Control M‐Type Voltage‐Gated Potassium Channels

Nanoenabled Bioelectrical Modulation

Gold photocatalysis in sustainable hydrogen peroxide generation

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