Gold-core silica shell nanoparticles application in imaging and therapy: A review

Moreira, André F.; Rodrigues, Carolina; Reis, Catarina A.; Costa, Elisabete C.; Correia, Ilídio J.

doi:10.1016/j.micromeso.2018.05.022

Cited by 74 publications

(57 citation statements)

References 122 publications

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“…In this nano-era, NPs from all kinds of raw materials have been tried to provide the designed drug-controlled release profiles, such as polymer, lipid, inorganic, and magnetic substances [ 11 , 70 , 71 , 72 , 73 , 74 ]. Based on the present protocols, there are some new strategies that can be applied for developing novel polymer coating NPs.…”

Section: Resultsmentioning

confidence: 99%

Electrosprayed Ultra-Thin Coating of Ethyl Cellulose on Drug Nanoparticles for Improved Sustained Release

Huang

Hanlin

et al. 2020

Nanomaterials

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In nanopharmaceutics, polymeric coating is a popular strategy for modifying the drug release kinetics and, thus, new methods for implementing the nanocoating processes are highly desired. In the present study, a modified coaxial electrospraying process was developed to formulate an ultra-thin layer of ethyl cellulose (EC) on a medicated composite core consisting of tamoxifen citrate (TAM) and EC. A traditional single-fluid blending electrospraying and its monolithic EC-TAM nanoparticles (NPs) were exploited to compare. The modified coaxial processes were demonstrated to be more continuous and robust. The created NPs with EC coating had a higher quality than the monolithic ones in terms of the shape, surface smoothness, and the uniform size distribution, as verified by the SEM and TEM results. XRD patterns suggested that TAM presented in all the NPs in an amorphous state thanks to the fine compatibility between EC and TAM, as indicated by the attenuated total reflection (ATR)-FTIR spectra. In vitro dissolution tests demonstrated that the NPs with EC coating required a time period of 7.58 h, 12.79 h, and 28.74 h for an accumulative release of 30%, 50%, and 90% of the loaded drug, respectively. The protocols reported here open a new way for developing novel medicated nanoparticles with functional coating.

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Section: Resultsmentioning

confidence: 99%

Electrosprayed Ultra-Thin Coating of Ethyl Cellulose on Drug Nanoparticles for Improved Sustained Release

Huang

Hanlin

et al. 2020

Nanomaterials

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“…Debido a la composición química relativamente inerte [3] de las NPs y a su capacidad de carga [48], estas han sido útiles para mejorar propiedades de biocompatibilidad en otras nanopartículas como por ejemplo las nanopartículas magnéticas (MNP) [43], así lo muestran Khanna et al [49] en donde se sintetizaron nanopartículas magnéticas por medio del proceso Sol-gel que fueron recubiertas con NPs como estabilizador para mejorar el comportamiento de las MNP en el entorno biológico, se observó que la viabilidad celular aumentó con el recubrimiento de NPs lo que refleja su biocompatibilidad mejorada. Jia et al [50], también usaron nanopartículas magnéticas con recubrimiento de sílice y observaron que hubo aceleración en la regeneración ósea lo que a su vez aumentó la biocompatibilidad y funcionalización del compuesto.…”

Section: Funcionalizaciones Y Recubrimientos De Las Nanopartículas Deunclassified

“…La primera capa (interna) tiene un revestimiento denso de NPs y la segunda capa (externa) se recubrió con MSN lo que dio como resultado un compuesto (Co@Silica@meso-Silica) altamente biocompatible. Moreira et al [48] también utilizaron la sílice como recubrimiento dando como resultado nanopartículas de sílice con núcleo de oro para aplicarlos principalmente en imagenología.…”

Section: Funcionalizaciones Y Recubrimientos De Las Nanopartículas Deunclassified

Obtención, funcionalización y aplicaciones biomédicas de las Nanopartículas de Sílice Mesoporosa: una revisión

Hincapie

Hernández

González

et al. 2020

DYNA

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Recientemente, las nanopartículas inorgánicas han sido ampliamente investigadas como agentes terapéuticos en los campos biomédicos debido a sus propiedades físicas, químicas y biológicas excepcionales, su fácil funcionalización superficial, su capacidad de carga y su excelente biocompatibilidad. El creciente aumento en investigaciones centradas en nanopartículas inorgánicas en especial las de sílice ha permitido entender su comportamiento en aplicaciones biomédicas, debido a que es un biomaterial con alta resistencia mecánica, bioactividad y reabsorbilidad mejoradas. En este artículo, se realiza la revisión de estudios recientes basados en Nanopartículas de Sílice Mesoporosa (MSN) cuyo enfoque principal se centra en diferentes métodos de síntesis, funcionalización y recubrimiento de superficie y algunas aplicaciones biomédicas como liberación controlada de fármacos e imágenes diagnósticas. Finalmente, se presentan los impactos de las modificaciones químicas de la superficie de las nanopartículas en cuanto a su biocompatibilidad y las diversas aplicaciones biomédicas debido a sus destacables características.

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“…Among these, some photothermal agents have attracted much attention. They can be used in treating prostate cancer by converting light into heat energy under laser irradiation resulting in thermal destruction of cancer cells at treatment sites [13][14][15][16][17][18][19][20][21][22][23]. One of the great advantages of photothermal therapy (PTT) is done through the use of near-IR (NIR) radiation.…”

Section: Introductionmentioning

confidence: 99%

Gold nanoparticle clusters for the investigation of therapeutic efficiency against prostate cancer under near-infrared irradiation

et al. 2020

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Gold particles have been widely used in the treatment of prostate cancer due to their unique optical properties, such as their light-heat conversion in response to near-infrared radiation. Due to well-defined synthesis mechanisms and simple manufacturing methods, gold particles have been fabricated in various sizes and shapes. However, the low photothermal transduction efficiency in their present form is a major obstacle to practical and therapeutic uses of these particles. In the current work, we present a silica-coated gold nanoparticle cluster to address the therapeutic limit of single gold nanoparticles (AuNPs) and use its photothermal effect for treatment against PC-3, a typical prostate cancer. Due to its specific nanostructure, this gold nanocluster showed three times higher photothermal transduction efficiency than free single AuNPs. Moreover, while free single particles easily clump and lose optical properties, this silica-coated cluster form remained stable for a longer time in a given medium. In photothermal tests under near-infrared radiation, the excellent therapeutic efficacy of gold nanoclusters, referred to as AuNC@SiO 2 , was observed in a preclinical sample. Only the samples with both injected nanoclusters followed by photothermal treatment showed completely degraded tumors after 15 days. Due to the unique intrinsic biocompatibility and higher therapeutic effect of these silica-coated gold nanoclusters, they may contribute to enhancement of therapeutic efficacy against prostate cancer.

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Gold-core silica shell nanoparticles application in imaging and therapy: A review

Cited by 74 publications

References 122 publications

Electrosprayed Ultra-Thin Coating of Ethyl Cellulose on Drug Nanoparticles for Improved Sustained Release

Electrosprayed Ultra-Thin Coating of Ethyl Cellulose on Drug Nanoparticles for Improved Sustained Release

Obtención, funcionalización y aplicaciones biomédicas de las Nanopartículas de Sílice Mesoporosa: una revisión

Gold nanoparticle clusters for the investigation of therapeutic efficiency against prostate cancer under near-infrared irradiation

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