Gold complexes with thiosemicarbazones: reactions of bi- and tridentate thiosemicarbazones with dichloro[2-(dimethylaminomethyl)phenyl-C 1,N ]gold(III), [Au(damp-C 1,N )Cl2]

Synthesis, characterisation and biological activity of gold(III) catecholate and related complexes

“…Today, a range of platinum (II) [and platinum(IV)] complexes are available in the clinic for cancer chemotherapy. [1,2] The similarity between platinum(II) and the isoelectronic (d 8 ) gold(III) suggests that certain complexes of the latter metal centre might also have promising cytotoxicity, [3] though the cytotoxicity of gold(III) complexes has been less studied than gold(I) thus far. [4] Although many simple gold(III) complexes such as [AuCl 4 ] -are too strongly oxidising to show useful antitumour properties, [1,5,6] derivatives containing cyclo-aurated aryl-amine or aryl-pyridine ligands show much greater stability, and are not reduced by sulfur-based ligands such as thiols and related ligands.…”

“…[4] Although many simple gold(III) complexes such as [AuCl 4 ] -are too strongly oxidising to show useful antitumour properties, [1,5,6] derivatives containing cyclo-aurated aryl-amine or aryl-pyridine ligands show much greater stability, and are not reduced by sulfur-based ligands such as thiols and related ligands. [7][8][9] This is significant since sulfur-based reductants occur widely in the cysteinyl and methionine residues in biological materials. Initial studies in this area showed that the gold(III) complexes 1 show good antitumour activity, and both the chemistry and biological activity have been evaluated quite extensively.…”

Chemistry, antiproliferative activity and low nephrotoxicity of 3,5-diacetyl-1,2,4-triazol bis(4N-thiosemicarbazone) ligands and their platinum(ii) complexes

“…27 The azomethine bond distances of 1.288(3) and 1.290(2) are in conformity with a formal C=N double bond and the C-S bond distances of 1.678 (2) and 1.684(2) Å , are very close to a formal C=S double bond 10 length, these facts confirm the existence of the thiosemicarbazone groups in the thione form, in the solid state. 28 However, the N( The molecular structure of platinum complex [Pt(m-H 1 L 1 )] 2 together with the atomic numbering scheme is shown in Fig. 2.…”

Complexes of pyridoxal thiosemicarbazones formed with vanadium(IV/V) and copper(II): Solution equilibrium and structure

“…In these complexes the PxTSC or its derivatives coordinate in a tridentate mode (except a few cases e.g. Au III [21] or dimethyl-Tl III [22] with bidentate coordination). The exact composition of the complexes depends on the coordination properties of the metal ion.…”