Gold-catalyzed intermolecular tandem cyclization/[4 + 3] cycloaddition of 2-(1-alkynyl)-cyclopropyl pyridines with nitrones: an efficient strategy for the synthesis of [1,2]oxazepino[5,4-a] indolizines

Abstract

A new and efficient approach is described for diastereoselective synthesis of [1,2]oxazepino[5,4-a] indolizines via Gold-catalyzed [4+3] cycloaddition reaction of 2-(1-alkynyl)-cyclopropyl pyridine with nitrones. This methodology provides great potential to build...