Gold‐based paper sensor for sensitive detection of procalcitonin in clinical samples

Xu, Xinxin; Lei, Xianlu; ye, liya; Song, Shanshan; Liliang, Liu; Xu, Liguang; Xu, Chuanlai; Kuang, Hua

doi:10.1016/j.cjac.2022.100062

Cited by 12 publications

(8 citation statements)

References 36 publications

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“…A gold-based paper sensor designed to detect PCT in clinical samples demonstrated a detection limit of 0.1 ng/ml and a detection range from 0.49 to 13.90 ng/ml (Fig. 10 A) [ 97 ]. To enhance sensitivity, researchers explored increasing the size of AuNPs.…”

Section: Immune Colloidal Gold Technique For Pct Detectionmentioning

confidence: 99%

Progress in Procalcitonin Detection Based on Immunoassay

Huang,

Zu,

Zhang

et al. 2024

Research

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Procalcitonin (PCT) serves as a crucial biomarker utilized in diverse clinical contexts, including sepsis diagnosis and emergency departments. Its applications extend to identifying pathogens, assessing infection severity, guiding drug administration, and implementing theranostic strategies. However, current clinical deployed methods cannot meet the needs for accurate or real-time quantitative monitoring of PCT. This review aims to introduce these emerging PCT immunoassay technologies, focusing on analyzing their advantages in improving detection performances, such as easy operation and high precision. The fundamental principles and characteristics of state-of-the-art methods are first introduced, including chemiluminescence, immunofluorescence, latex-enhanced turbidity, enzyme-linked immunosorbent, colloidal gold immunochromatography, and radioimmunoassay. Then, improved methods using new materials and new technologies are briefly described, for instance, the combination with responsive nanomaterials, Raman spectroscopy, and digital microfluidics. Finally, the detection performance parameters of these methods and the clinical importance of PCT detection are also discussed.

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Section: Immune Colloidal Gold Technique For Pct Detectionmentioning

confidence: 99%

Progress in Procalcitonin Detection Based on Immunoassay

Huang,

Zu,

Zhang

et al. 2024

Research

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“…PCT is often used as a particular biomarker for sepsis and bacterial infection, as it seldom increases due to or non‐infectious inflammatory or viral. [ 214 ]…”

Section: Functional Nanomaterials In Assaying Biomarkersmentioning

confidence: 99%

“…PCT is often used as a particular biomarker for sepsis and bacterial infection, as it seldom increases due to or non-infectious inflammatory or viral. [214] Due to the shortage of samples in this population, which is also more prone to the development of sepsis, a fluorescent immunosensor using micromotor for PCT determination in the plasma of extremely low birth weight newborns was developed. The micromotors were synthesized, and a Ni layer was integrated on the inner side of the micromotors for magnetic control.…”

Section: Procalcitonin (Pct) Sensingmentioning

confidence: 99%

Recent advances in nanomaterials‐based optical sensors for detection of various biomarkers (inorganic species, organic and biomolecules)

Harshita

Kailasa

2022

Luminescence

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This review briefly emphasizes the different detection approaches (electrochemical sensors, chemiluminescence, surface‐enhanced Raman scattering), functional nanostructure materials (quantum dots, metal nanoparticles, metal nanoclusters, magnetic nanomaterials, metal oxide nanoparticles, polymer‐based nanomaterials, and carbonaceous nanomaterials) and detection mechanisms. Furthermore, the emphasis of this review is on the integration of functional nanomaterials with optical spectroscopic techniques for the identification of various biomarkers (nucleic acids, glucose, uric acid, oxytocin, dopamine, ascorbic acid, bilirubin, spermine, serotonin, thiocyanate, Pb2+, Cu2+, Hg2+, F−, peptides), and cancer biomarkers (mucin 1, prostate specific antigen, carcinoembryonic antigen, CA15‐3, human epidermal growth factor receptor 2, C‐reactive protein, and interleukin‐6). Analytical characteristics of nanomaterials‐based optical sensors are summarized in the tables, providing the insights of nanomaterials‐based optical sensors for biomarkers detection. Finally, the opportunities and challenges of nanomaterials‐based optical analytical approaches for the detection of various biomarkers (inorganic, organic, biomolecules, peptides and proteins) are discussed.

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“…The latest test results of the National Environmental Testing Station show that the national surface water is generally lightly polluted status quo, and the main pollutants are divided into five important indicators, of which ammonia nitrogen is one of the five important indicators in urban sludge [1], sewage, rural fertilizers, feed, plant soil, and surface water is widely present, the detection of ammonia nitrogen index has therefore become a common problem faced in the treatment of drinking water [2]. At present, the gas phase reversible colorimetric method, indophenol blue method, nano reagent spectrophotometric method, and salicylic acid spectrophotometric method is the main method of ammonia nitrogen detection, because the salicylic acid method has the advantage of higher accuracy and precision, is widely used in the determination of water quality ammonia nitrogen index, so this paper selected salicylic acid method to carry out experimental verification [3][4][5][6].…”

Section: Introductionmentioning

confidence: 99%

Design of High-precision Water Quality Ammonia Nitrogen Online Detection Technology System Based on Micro-control Technology

Wang,

Wen,

Ming-Gang

et al. 2023

J. Phys.: Conf. Ser.

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Based on Lambert’s theorem, this paper adopts the integration of micro-control technology and sequential injection technology and designs a water-quality ammonia nitrogen online detection system to improve the accuracy of ammonia nitrogen detection and to solve the demand for the determination of ammonia nitrogen index in the surface I to V water. The linearity of the assay data can be improved by controlling the variables in a control experiment, reducing the volume of the digestion cell, and reducing the inner diameter of the Teflon tube. Compared with the traditional ammonia nitrogen detection system, it has higher detection accuracy, and the number of reagents used and waste liquid generated have been greatly reduced, effectively improving the accuracy of ammonia nitrogen index detection. In this experiment, the determination of the ammonia nitrogen index was accomplished by salicylic acid spectrophotometry, and the range of determination covered the standard limits of ammonia nitrogen in a surface water environment from Class I to V water. The experimental results showed that: The regression model for the detection of ammonia index by the salicylic acid method was developed using the least squares fitting algorithm, and the linear range was from 0 to 2 mg/mL. The correlation coefficient of the experimental data for the 10 mm inner diameter tube was 0.9981 and that for the 15 mm inner diameter tube was 0.923. And the concentration and absorbance were both positively correlated, and the trend of the experimental data was consistent with the theoretical analysis. The system is designed to reduce operation and maintenance costs, improve detection accuracy, and efficiently analyze the ammonia nitrogen index in surface I-V water, providing technical support for environmental protection and surface water quality monitoring.

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Gold‐based paper sensor for sensitive detection of procalcitonin in clinical samples

Cited by 12 publications

References 36 publications

Progress in Procalcitonin Detection Based on Immunoassay

Progress in Procalcitonin Detection Based on Immunoassay

Recent advances in nanomaterials‐based optical sensors for detection of various biomarkers (inorganic species, organic and biomolecules)

Design of High-precision Water Quality Ammonia Nitrogen Online Detection Technology System Based on Micro-control Technology

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