Gold and gold salts

doi:10.1016/b978-0-444-53717-1.00818-0

Cited by 1 publication

(1 citation statement)

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“…However, much higher doses of AF, alone or in combination with other drugs, were needed in vivo to inhibit TrxR activity in the tumors of mice, as shown by our results and others (Table 1). Therefore, it might prove challenging to obtain sufficiently high concentrations of AF in the patient's tumor without increasing unwanted side-effects [4,64,65]. New technological innovations, such as AF-loaded nanoparticles, could offer a possible solution since they are able to enhance drug localization in the target site and minimize systemic cytotoxicity [66,67].…”

Section: Discussionmentioning

confidence: 99%

Optimization of the Solvent and In Vivo Administration Route of Auranofin in a Syngeneic Non-Small Cell Lung Cancer and Glioblastoma Mouse Model

et al. 2022

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The antineoplastic activity of the thioredoxin reductase 1 (TrxR) inhibitor, auranofin (AF), has already been investigated in various cancer mouse models as a single drug, or in combination with other molecules. However, there are inconsistencies in the literature on the solvent, dose and administration route of AF treatment in vivo. Therefore, we investigated the solvent and administration route of AF in a syngeneic SB28 glioblastoma (GBM) C57BL/6J and a 344SQ non-small cell lung cancer 129S2/SvPasCrl (129) mouse model. Compared to daily intraperitoneal injections and subcutaneous delivery of AF via osmotic minipumps, oral gavage for 14 days was the most suitable administration route for high doses of AF (10–15 mg/kg) in both mouse models, showing no measurable weight loss or signs of toxicity. A solvent comprising 50% DMSO, 40% PEG300 and 10% ethanol improved the solubility of AF for oral administration in mice. In addition, we confirmed that AF was a potent TrxR inhibitor in SB28 GBM tumors at high doses. Taken together, our results and results in the literature indicate the therapeutic value of AF in several in vivo cancer models, and provide relevant information about AF’s optimal administration route and solvent in two syngeneic cancer mouse models.

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