Gold and aluminum based surface plasmon resonance biosensors: sensitivity enhancement

Interface‐Engineered 2D Heterojunction with Photoelectric Dual Gain: Mxene@MOF‐Enhanced SPR Spectroscopy for Direct Sensing of Exosomes

“…The results show that Oxi-Mxene causes an abnormal increase in the FWHM of SPR, corresponding to the increase in the width of the resonance angle in Figure 6B, showing the negative effect of Oxi-Mxene on the SPR sensor. The results for both D.A and FOM show (Figure 6H,I) that the values of key parameters for the Oxi-M@M-modified SPR sensors vary MoS 2 nanosheet 81.60 3.44 [48] Graphene sheet coated on silver 68.03 9.69 [49] 2D MOF 123.33 21.26 [24] Gold and aluminum thin film coating 9.56 2.31 [50] Au-graphene-MoS 2 hybrid 89.29 17.56 [51] Gold/ 3D NS 108.83 28.68 [39] Graphene-coated black phosphorus 125.00 13.62 [52] zinc oxide/gold/MoS 2 /graphene 101.58 15.11 [53] Cu-TCPP 137.67 24.81 [37] Mxene@MOF 166.17 39.6 This work relatively little. Finally, MXene and MXene@MOF aqueous suspensions were placed at the same room temperature conditions to investigate the stability of the SPR enhancement ability of both materials with increasing oxidation time.…”

Surface Plasmon Resonance: Material and Interface Design for Universal Accessibility

“…Many of these newly developed semiconductor and hybrid metamaterials, in addition to a summary of the shortcomings of conventional plasmonic materials, are thoroughly discussed within a review by Naik et al 91 As an example, one recent frontrunner material for SPR sensing is aluminum, which is capable of supporting SPPs in the visible, deep UV, and far UV regions of the electromagnetic spectrum. 92–95 Ozaki and co-workers have noted higher refractive index sensitivities using aluminum SPR sensors with UV excitation compared to gold SPR sensors with red excitation in both air and aqueous conditions under angular interrogation. 93,94 Geiss et al expanded on these studies in a more applied manner through measurement of protein binding using UV SPR.…”

“…Outside the realm of noble metals, a plethora of materials exist that are capable of supporting surface plasmons, from semiconductors to 2D materials such as graphene. Many of these newly developed semiconductor and hybrid metamaterials, in addition to a summary of the shortcomings of conventional plasmonic materials, are thoroughly discussed within a review by Naik et al As an example, one recent frontrunner material for SPR sensing is aluminum, which is capable of supporting SPPs in the visible, deep UV, and far UV regions of the electromagnetic spectrum. − Ozaki and co-workers have noted higher refractive index sensitivities using aluminum SPR sensors with UV excitation compared to gold SPR sensors with red excitation in both air and aqueous conditions under angular interrogation. , Geiss et al expanded on these studies in a more applied manner through measurement of protein binding using UV SPR . While aluminum forms a native oxide layer at the surface in ambient air, unlike silver, which is more likely to undergo sulfidation, the sensor is amenable to common silane chemistries, which were used for covalent coupling of NTA for protein attachment.…”

Rapid and Sensitive Detection by Combining Electric Field Effects and Surface Plasmon Resonance: A Theoretical Study

“…To improve the sensitivity of the SPR sensor system and conform to the needs of the ultra-sensitive detection of trace disease biomarkers, the commonly used method is to Micromachines 2024, 15, 653 2 of 14 enhance the detection sensitivity and stability of SPR by introducing nanomaterials and different topology structures. Nanomaterials (e.g., graphene and molybdenum disulfide) possess a larger specific surface area, high electron mobility, and light absorption rate; a sensitization layer to enhance the SPR signal can be built by the aid of nanomaterials without disturbing the interaction of the biomolecules, which can increase the sensitivity of the SPR and provide precise detection for trace biomarkers [8]. Zhihui Mao proposed a method via graphene to change the surface of the sensor chip to detect PD-L1 exosomes, and the detection limit of 20 particles mL −1 was reached without signal amplification [9].…”