Goji Berry Effects on Macular Characteristics and Plasma Antioxidant Levels

Bucheli, Peter; Vidal, Karine; Shen, Lisong; Gu, Zhencheng; Zhang, Charlie; Miller, Larry E.; Wang, Junkuan

doi:10.1097/opx.0b013e318205a18f

Cited by 72 publications

(44 citation statements)

References 20 publications

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“…Individuals in the S group included 14 g of in natura GB on meals. The choice of the amount of GB administered was based on a previous study conducted by Bucheli et al [28] in volunteers between 65 and 70 years. In that study, Bucheli et al showed positive effects in the use of GB.…”

Section: Methodsmentioning

confidence: 99%

“…Lycium barbarum , a traditional Chinese medicine plant, is a small red fruit widely consumed in China due to its benefits to vision, kidney, liver, and diseases such as diabetes mellitus and obesity [19]. It is considered the richest natural source of antioxidants vitamin C, flavonoids, and carotenoids especially zeaxanthin, quercetin, and rutin [20–22].…”

Section: Introductionmentioning

confidence: 99%

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Lycium barbarum Reduces Abdominal Fat and Improves Lipid Profile and Antioxidant Status in Patients with Metabolic Syndrome

Zanchet

Nardi

Bratti

et al. 2017

Oxidative Medicine and Cellular Longevity

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Natural antioxidants present in fruits have attracted considerable interest due to their presumed safety and potential nutritional value. Even though antioxidant activities of many fruits have been reported, the effects of phytochemicals of goji berry (GB) in patients with metabolic syndrome have not been investigated. In this study, we examined anthropometric and biochemical parameters in patients with metabolic syndrome after the consumption of GB. The patients were divided into two groups, control (C) and supplemented (S), and followed up for 45 days. Participants were individually instructed to carry out a healthy diet, but additionally, an inclusion of 14 g of the natural form of goji berry in the diet during 45 days for the S group was proposed. After 45 days of study, a significant reduction in transaminases as well as an improvement in lipid profile in the S group was observed. Likewise, a significant reduction in the waist circumference of the S group was observed when compared with that of the C group, and increased glutathione and catalase levels associated with a reduction of lipid peroxidation. These results suggest that this is an effective dietary supplement for the prevention of cardiovascular diseases in individuals with metabolic syndrome.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Lycium barbarum Reduces Abdominal Fat and Improves Lipid Profile and Antioxidant Status in Patients with Metabolic Syndrome

Zanchet

Nardi

Bratti

et al. 2017

Oxidative Medicine and Cellular Longevity

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“…A mouse consumes ;3 g/d of diet, which translates into a daily consumption of wolfberry at 5 g/kg body weight for a mouse weighing 30 g. When this dose is converted from mice consuming 12 kJ/d to humans consuming 2000 kJ/d, using isocaloric calculation (51,52), it is equivalent to 0.18 g/kg body weight in humans, or 12.6 g/d consumed by a person weighing 70 kg. A recent study showed that the elderly subjects (aged 65-70 y) receiving 13.7 g/d of LWB for 3 mo had improved macular characteristics compared with the placebo group (50). Thus, the dose used in the current study is both feasible to be consumed by humans and could have translational potential.…”

Section: Discussionmentioning

confidence: 84%

Dietary Supplementation with Lacto-Wolfberry Enhances the Immune Response and Reduces Pathogenesis to Influenza Infection in Mice,

Ren

et al. 2012

The Journal of Nutrition

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Despite the availability of vaccines, influenza is a considerable public health problem, which emphasizes the need for development of additional strategies to enhance host defense against influenza. Wolfberry, or goji berry, long used as a medicinal food in China, has recently been shown to improve immune response in mice. Because immune response plays a key role in the body's defense against pathogens, we hypothesized that wolfberry may increase host resistance to influenza infection by enhancing immune response. To test this hypothesis, we fed adult mice (4 mo old) a milk-based preparation of wolfberry called Lacto-Wolfberry (LWB) for 4 wk and then infected them with influenza A/Puerto Rico/8/34 (H1N1) while continuing the same experimental diets. Viral titer, lung pathology, and immune response were determined at different time points postinfection. LWB supplementation prevented infection-induced weight loss and reduced lung pathology on days 6 and 9 postinfection (P < 0.05). LWB-fed mice showed overall, significantly higher concanavalin A-induced IL-2 production (P < 0.05). Furthermore, we found positive correlations between weight loss and lung viral titer, pathology score, TNFα, and IL-6 production as well as negative correlations with T cell proliferation and IL-2 production (all P ≤ 0.05). These results indicate that LWB supplementation can attenuate symptoms and pathology of influenza infection by decreasing inflammatory cytokines in lungs while enhancing systemic T cell-mediated function as measured by their ability to produce IL-2.

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“…Considering this, some experiments have investigated the therapeutic effect of the LBA on the visual defect. As LBA is one of the richest natural sources of ze axanthin [2], previous investigations found that daily dietary supplementation with LBA could increase plasma zeaxanthin and antioxidant levels as well as protects from hypopigmentation in the macula of elderly subjects [5]. In addition, oral administration of LBA could significantly reduce the loss of retinal ganglion cells in rats with glaucoma by decreasing the ocular hypertension [7].…”

Section: Introductionmentioning

confidence: 99%

Original article Neuroprotective effect of Lycium barbarum on retina of Royal College of Surgeons (RCS) rats: a preliminary study

Wei²,

Yin³

et al. 2013

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A b s t r a c t Hereditary retinal dystrophy usually leads to blindness. Using Royal College of Surgeons (RCS) rats as a hereditary retinal dystrophy model, we investigated the possible neuroprotective effects of the aqueous extract of dried Lycium barbarum (LBA). Sixty postnatal RCS rats were selected and randomly divided into a control group (CG, thirty rats) and an experimental group (EG). Ten days after birth, EG rats were treated by 1 mg/kg of LBA per day, and CG rats were normally fed. These rats were killed at postnatal day (P) 25, P35 and P50, and retinal tissue was prepared for analysis. Photoreceptor cells were assessed by hematoxylin and eosin (HE) staining, TUNEL detection and Caspase-2 protein expression. We found that in rats at P25, the outer nuclear layer (ONL) of EG was thicker and more photoreceptor cells survived. Meanwhile, the TUNEL expression in EG was

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Goji Berry Effects on Macular Characteristics and Plasma Antioxidant Levels

Cited by 72 publications

References 20 publications

Lycium barbarum Reduces Abdominal Fat and Improves Lipid Profile and Antioxidant Status in Patients with Metabolic Syndrome

Lycium barbarum Reduces Abdominal Fat and Improves Lipid Profile and Antioxidant Status in Patients with Metabolic Syndrome

Dietary Supplementation with Lacto-Wolfberry Enhances the Immune Response and Reduces Pathogenesis to Influenza Infection in Mice,

Original article Neuroprotective effect of Lycium barbarum on retina of Royal College of Surgeons (RCS) rats: a preliminary study

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