Goitrogenic activity of <i>p</i>‐coumaric acid in rats

Khelifi-Touhami, Fatima; Taha, Ragia A.; Badary, Osama A.; Lezzar, A.; Hamada, Farid M.A.

doi:10.1002/jbt.10094

Cited by 14 publications

(5 citation statements)

References 21 publications

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“…Despite its enormous usefulness and potential health benefits, flavonoids emerge as phytochemicals of great concern due to their antithyroidal and goitrogenic effect. It has previously been reported that the consumption of flavonoids and some phenolic acids by experimental animals induced enlargement and histological changes in the thyroid gland [5][6][7][8][9] . Studies on effects of tea extracts on thyroid physiology are not available though it is used as whole beverage rather taking any single component of it, so this is very plausible to investigate the effect of total green tea extract on rats.…”

Section: Introductionmentioning

confidence: 99%

Goitrogenic and Antithyroid Potential of Green Tea of Indian Origin

Chandra

2015

J Bangladesh Soc Physiol

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Polyphenolic flavonoids, specially catechins are major constituents of tea. Antithyroidal and goitrogenic effect of flavonoids have been reported however such effects of green tea on thyroid physiology has not been explored earlier. Green tea is derived from the tea leaves of Camellia sinensis and widely consumed globally. The green tea extracts(GTE) at different concentrations (1.25g% a 5 cups of tea/ day; 2.5g% a 10 cups of tea/ day and 5.0g% a 20 cups of tea/ day) were orally fed to male rats for 30 days. Similarly, pure catechin was administered orally to male albino rats for 30 days at doses of 25, 50 and 100 mg/kg body weight that are equivalent to above doses of green tea extract in terms of its total catechin content and the morphological and functional changes of the thyroid have been investigated. The overall results reveal that oral administration of green tea extract at 2.5g% and 5.0g% concentrations for 30 days changed the morphology and histology resembling hypertrophy of thyroid follicles with differential colloid sizes as found in hypothyroid due to environment influences associated with significant inhibited activities of thyroid peroxidase(TPO) and 5 monodeiodinase (5 DI1) with elevated Na+,K+ ATPase and concomitant decrease in serum thyroxine (T4), triiodothyronine (T3) and increase in serum thyrotropin (TSH) levels developing a state of absolute biochemical hypothyroidism. All these suggest that catechin present in green tea has the antithyroidal as well as goitrogenic potential and its regular consumption at relatively high doses pose a threat to the functioning of thyroid. DOI: http://dx.doi.org/10.3329/jbsp.v9i2.22807 Bangladesh Soc Physiol. 2014, December; 9(2): 105-116

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Section: Introductionmentioning

confidence: 99%

Goitrogenic and Antithyroid Potential of Green Tea of Indian Origin

Chandra

2015

J Bangladesh Soc Physiol

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“…It has previously been reported that the consumption of flavonoids and some phenolic acids by experimental animals induced enlargement and histological changes in the thyroid gland. [8][9][10][11][12] Previous study reported that after a 13-weeks oral administration of polyphenone-60 (P-60), which is green tea extract (GTE) catechins, it was found that this treatment at high dose induced goiters in rats. 13,14 However, studies on the un-fractionated tea extracts on thyroid physiology are not available though tea is used as whole beverage rather than taking any single component of it, so it is very essential to study the effect of un-fractionated green and black tea extracts on rats.…”

Section: Introductionmentioning

confidence: 99%

Effect of different doses of un-fractionated green and black tea extracts on thyroid physiology

Chandra

Choudhury

2010

Hum Exp Toxicol

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Tea is a rich source of polyphenolic flavonoids including catechins, which are thought to contribute to the health benefits of it. Flavonoids have been reported to have antithyroid and goitrogenic effect. The purpose of this study was to evaluate whether high doses of green and black tea have a harmful effect on thyroid physiology. Un-fractionated green and black tea extracts were administered orally to male rats for 30 days at doses of 1.25 g%, 2.5 g% and 5.0 g%. The results showed that green tea extract at 2.5 g% and 5.0 g% doses and black tea extract only at 5.0 g% dose have the potential to alter the thyroid gland physiology and architecture, that is, enlargement of thyroid gland as well as hypertrophy and/or hyperplasia of the thyroid follicles and inhibition of the activity of thyroid peroxidase and 5′-deiodinase I with elevated thyroidal Na+, K+-ATPase activity along with significant decrease in serum T3 and T4, and a parallel increase in serum thyroid stimulating hormone (TSH). This study concludes that goitrogenic/antithyroidal potential of un-fractionated green tea extract is much more than black tea extract because of the differences in catechin contents in the tea extracts.

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“…However, m-coumaric acid has been suggested as the weakest antioxidant among hydroxycinnamic acids ( 22 , 23 ). Although oral supplementation of p-coumaric acid had significant goitrogenic effect in rat models ( 24 ), the impact of m-coumaric acid on thyroid has not been studied. In the present study, we found that p-coumaric acid levels were not different between the two groups, while m-coumaric acid levels were significantly higher in GD groups, compared to those in controls.…”

Section: Discussionmentioning

confidence: 99%

Identification of Novel Environmental Substances Relevant to Pediatric Graves’ Disease

Qin

Liu

et al. 2021

Front. Endocrinol.

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Graves’ disease (GD) is the most common cause of hyperthyroidism, yet a relatively rare disease in the pediatric population. GD is a complex disorder influenced by both genetic and environmental factors. In this study, we aimed to find new environmental factors influencing the pathogenesis of GD. We investigated serum substances in 30 newly diagnosed GD children and 30 age- and gender-matched healthy controls. We measured total iodine by inductively coupled plasma-mass spectrometry (ICP-MS), analyzed perfluorinated compounds via ultra-high-performance liquid chromatography coupled with multiple reaction monitoring mass spectrometry (UHPLC-MRM-MS), and explored other environmental substances using ultra-high-performance liquid chromatography–quadrupole time-of-flight mass spectrometry (UHPLC–QTOF/MS) analysis. Twenty-nine single-nucleotide polymorphisms (SNPs) in eight genes related to GD were analyzed by SNaPshot. The serum total iodine was significantly higher in GD group, but its association with GD onset was weak, only with Exp(B) value near 1. The perfluorinated compound levels were not different between the two groups. More importantly, we found 16 environmental substances significantly different between GD and control groups, among which ponasterone A is a risk factor (p = 0.007 and Exp(B) = 14.14), while confertifoline is a protective factor against GD onset (p = 0.002 and Exp(B) = 0.001). We also identified 10 substances correlated significantly with thyroid indices in GD patients, among which seven associated with levels of the thyroid autoantibody TPOAb. No known SNPs were found predisposing GD. In this study, we explored a broad variety of environmental substances and identified novel factors that are potentially involved in the pediatric GD pathogenesis.

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Goitrogenic activity of p‐coumaric acid in rats

Cited by 14 publications

References 21 publications

Goitrogenic and Antithyroid Potential of Green Tea of Indian Origin

Goitrogenic and Antithyroid Potential of Green Tea of Indian Origin

Effect of different doses of un-fractionated green and black tea extracts on thyroid physiology

Identification of Novel Environmental Substances Relevant to Pediatric Graves’ Disease

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