Goitre Prophylaxis in New Guinea With Intramuscular Injections of Iodized Oil

Hennessy, W. B.

doi:10.5694/j.1326-5377.1964.tb134328.x

Cited by 27 publications

(4 citation statements)

References 10 publications

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“…Evidence of an overall correlation between visible goitre rate and the incidence of cretinism was obtained, which supports previous evidence from the Huon Peninsula (McCullagh, 1963b ;Hennessy, 1964). This is also consistent with the South American data of Greenwald (1959), who noted a striking correlation between the incidence of goitre and deaf-mutism in Pem and Argentina.…”

Section: Discussionsupporting

confidence: 90%

Endemic Cretinism in Eastern New Guinea

Hetzel

1969

Australasian Annals of Medicine

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SUMMARY A study has been carried out of the clinical features, epidemiology and thyroid function in 254 cases of endemic cretinism in Eastern New Guinea. The clinical picture resembles closely that described for Western New Guinea and other endemic goitre areas throughout the world. Goitre was encountered more commonly in mothers of cretins than in adult females of the studied population. Examination of thyroid function revealed a significantly lower serum PBI value and I uptake in cretins when compared with neurologically normal natives. No clinical evidence of hypothyroidism was encountered in endemic cretins, and no biosynthetic defect was isolated as shown by perchlorate discharge testing and chromatography of I131 labelled thyroid glands and serum. Mothers of 13 cretins, born since the introduction of iodized oil prophylaxis, were identified, and in only one instance was there a possibility that iodine therapy had been given. These findings suggest that the condition is related to iodine deficiency and may be prevented by correction of maternal iodine deficiency.

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Section: Discussionsupporting

confidence: 90%

Endemic Cretinism in Eastern New Guinea

Hetzel

1969

Australasian Annals of Medicine

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“…The changes observed 1 year after iodized oil injections were consistent with the effect of an acute, large iodine load. The marked reduction in goitre size, in 80% of the treated population, was similar to the findings in other studies using iodized oil (Hennessy, 1964;Pretell et al, 1969;Thilly et al, 1973;Lagasse et al, 1980). After iodized oil, urinary iodine concentrations rose 15-fold to 2.6L2.5 pmol/l, which is six times higher than that required to prevent goitre (Koutras et al, 1980).…”

Section: Discussionsupporting

confidence: 89%

“…The Jod Basedow effect, i.e. an increased incidence of thyrotoxicosis (Kocher, 1910) following iodized oil injections, is said not to occur (Hennessy et al, 1964;Pretell et al, 1969;Ibbertson et al, 1971;Thilly et al, 1973Thilly et al, , 1980Lagasse et al, 1980). Therefore, a programme was designed to inject the villagers of Lubok Antu with iodized oil in an attempt to alleviate their endemic goitre.…”

Section: G F Maberly Et Almentioning

confidence: 99%

The Effect of Iodized Oil on Goitre Size, Thyroid Function and the Development of the Jod Basedow Phenomenon*

Maberly

Corcoran

Eastman

1982

Clinical Endocrinology

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SUMMARY In the Lubok Antu district of Sarawak, Malaysia, 240 subjects with 75% prevalence of goitre were studied before and at intervals of 1 and 2 years following iodized oil injection. After 1 year the prevalence of goitre was reduced to 33%, but 2 years after injection, goitres had regrown in fourteen subjects (6%). The mean urinary iodine concentration was low initially at 0±17±0±08 (SD) μmol/l, consistent with iodine deficiency, and rose to a level of 2±6 ± 2±5 μmol/l at 1 year, before falling to 0±46 ± 0±38 μmol/l, again consistent with deficiency. Such a rapid depletion of iodine may be related to the high consumption of cassava. Before injection serum TSH concentrations showed a wide scatter from normal up to 62 mU/l and at 1 year, serum TSH concentrations were undetectable. At 2 years serum TSH was again detectable in 50% of subjects with levels up to 8±6 mu/l. During the 2 years, there was a progressive rise in the mean serum T4 concentration from 92 ± 22 (SD) nmol/l to 110 ± 22 nmol/l (P < 0±05). Serum T3 concentrations rose serially in all subjects from a pre‐injection mean of 1±9 ± 0±3 nmol/l to 2±5 ± 0±9 nmol/l (P < 0±001) and then fell significantly below the baseline level to a mean of 1±7 ± 0±6 nmol/l 2 years after injection (P < 0±01). The mean serum rT3 levels followed the same trend. At 1 or 2 years following injection, eight subjects were clinically hyperthyroid. Four of these consented to venesection and hyperthyroidism was confirmed biochemically. These data reveal that: goitres decreased rapidly in size in response to iodized oil injection; 2 significant though incomplete depletion of the iodine stores occurred within 2 years of injection; the consistent increase in serum T3 was associated with a fall in serum TSH to undetectable levels; the prevalence of the Jod Basedow phenomenon was l±7%. These data suggest the need for closer biochemical monitoring of subjects receiving massive doses of iodine and a reappraisal of the use of iodized oil in the treatment of endemic goitre.

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“…Ενέσεις ιωδιωμένου ελαίου πραγματοποιήθηκαν στα πλαίσια προγραμμάτων ιωδίωσης σε πολλές χώρες (Hetzel et al, 1980;Dunn 1987) όπως Κίνα, Ινδονησία, Νέα Γουϊνέα (Me Cullagh 1963Hennessy 1964;Buttfield and Hetzel, 1967), Βραζιλία, Περού (Pretell et al, 1969;Pretell et al, 1972), κεντρική Αφρική (Delange, 1974), Zäip, στα νησιά Idjwi (Thilly et al, 1973), Τανζανία (Wächter et al, 1986), (Abdel-Wahab et al, 1984). Ιωδιωμένο έλαιο im χορηγήθηκε επίσης σε αγόρια (Azizi et al, 1996) και κορίτσια (Azizi et al, 1997) σε ιωδιοπενική περιοχή του Ιράν για τη βελτίωση της θυρεοειδικής λειτουργίας.…”

Section: αντιμετώπιση της ιωδιοπενίαςunclassified

Κλινικές Μορφολογικές Και Ανοσολογικές Μελέτες Μετά Τη Χορήγηση Ιωδιωμένου Ελαίου Σε Ασθενείς Με Μη Τοξική Βρογχοκήλη

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Goitre Prophylaxis in New Guinea With Intramuscular Injections of Iodized Oil

Cited by 27 publications

References 10 publications

Endemic Cretinism in Eastern New Guinea

Endemic Cretinism in Eastern New Guinea

The Effect of Iodized Oil on Goitre Size, Thyroid Function and the Development of the Jod Basedow Phenomenon*

Κλινικές Μορφολογικές Και Ανοσολογικές Μελέτες Μετά Τη Χορήγηση Ιωδιωμένου Ελαίου Σε Ασθενείς Με Μη Τοξική Βρογχοκήλη

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