Goiter of the Newborn

Petty, Charles S.; DiBENEDETTO, Robert

doi:10.1056/nejm195706062562307

Cited by 24 publications

(1 citation statement)

References 16 publications

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“…If the goitrous thyroid of the infant is large enough, the infant may not be able to breathe at birth. (34,35) Other experience indicates that the goiter of the newborn may regress and normal thyroid function ensue without therapy. (36) Long-term administration of iodide appears to be contra-indicated for individuals suffering from chronic renal and cardiac failure and in cases of pulmonary tuberculosis.…”

mentioning

confidence: 98%

Prophylactic and Therapeutic Measures for Radioiodine Contamination—A Review

Fw¹,

Jc²

1963

Health Physics

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mentioning

confidence: 98%

Prophylactic and Therapeutic Measures for Radioiodine Contamination—A Review

Fw¹,

Jc²

1963

Health Physics

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Goiter and Thyroid Dysfunction Following the Use of Iodides in Asthmatic Children

Falliers¹

1960

Arch Pediatr Adolesc Med

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Although preparations containing iodine have been employed since the dawn of medicine, when burnt seaweed was prescribed for the treatment of goiter,1 reports on the occurrence of goiter and thyroid dysfunction directly attributable to the administration of iodides appeared only since 1953 and are still relatively few.Since the discovery of the element in the early 19th century physicians have empirically prescribed its various compounds for a multiplicity of clinical disorders. The use of iodide preparations as expectorants is one of the main current therapeutic applications of the drug. The rationale for its administration is its ability to stimulate bronchial secretion and produce liquefaction and reduction of the viscosity of sputum.2 Many preparations intended for the relief of bronchial asthma contain iodide and in many cases patients have been known to take such drugs continuously for many months or years.Certain undesirable side-effects of the prolonged administration of iodides are widely recognized.3 Consequently, it seems rather surprising that reports regarding the effects of iodides on the presumably normal thyroid gland appeared only during the last decade.In the most recent edition of a textbook of pharmacology,2 it is stated that "the normal thyroid gland is uninfluenced by iodide," and as recently as 1953, Morgans and Trot¬ ter,4 reporting two cases oí myxedema at¬ tributed to iodide administration, stated that "there is no recorded instance known to us of clinical hypothyroidism resulting from the administration of iodides." They men¬ tioned, however, their familiarity with Bell's observations published that same year.5 Bell reported four patients with goiter, three of whom also had myxedema. Three of the four patients were asthmatics and had re¬ ceived iodides for varying periods of time.One of these, an 11-year-old asthmatic girl, had a subtotal thyroidectomy, and histologi¬ cal examination showed colloid-storage goiter. Turner and Howard'6 and Turner,7 reporting on the goitrogenic effect of iodides among asthmatic children, offered evidence suggesting that this syndrome may not be as rare as previously thought. Glaser, never¬ theless, noted8 that the incidence of goiter among children treated with iodides is very low, which led him to conclude, "There must be some factor other than just the allergic state and the iodine which predis¬ poses to the development of goiter." Indeed, in a review of the literature,4"7,9·15"18 a total of 29 cases of goiter, with or without myxedema were found, which were attribut¬ able to an unphysiological quantity of iodine or iodides. Of these 29 cases, 27 were asthmatics; 16 were children under the age of 14 years, 8 of them boys and 8 girls.It was felt that the present report of four cases of goiter observed at the Jewish Na¬ tional Home for Asthmatic Children, in Denver, and related to the administration of iodides and the brief review of the literature appended may be of interest, since this ap¬ pears to be another iatrogenic disorder which should be more wide...

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Human Experiences Related to Adverse Drug Reactions to the Fetus or Neonate from Some Maternally Administered Drugs

Shirkey

1972

Advances in Experimental Medicine and Biology

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Goiter of the Newborn

Cited by 24 publications

References 16 publications

Prophylactic and Therapeutic Measures for Radioiodine Contamination—A Review

Prophylactic and Therapeutic Measures for Radioiodine Contamination—A Review

Goiter and Thyroid Dysfunction Following the Use of Iodides in Asthmatic Children

Human Experiences Related to Adverse Drug Reactions to the Fetus or Neonate from Some Maternally Administered Drugs

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