Going below and beyond the surface: Microneedle structure, materials, drugs, fabrication, and applications for wound healing and tissue regeneration

Lyu, Shang; Dong, Zhifei; Xu, Xinhe; Bei, Ho‐Pan; Yuen, Ho Yin; Cheung, James Chung-Wai; Wong, Man Sang; He, Yong; Zhao, Xin

doi:10.1016/j.bioactmat.2023.04.003

Cited by 46 publications

(36 citation statements)

References 193 publications

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“…Therefore, inorganic MNs are usually used to open pores on the skin to promote drug penetration in the form of hollow MNs or solid MNs coated with drugs on their surfaces. 16…”

Section: Characteristics Of the Mn Partmentioning

confidence: 99%

“…A wide variety of polymer monomers, various cross-linking methods and chemical modification techniques enable polymers to be mixed with different types of drug (including small molecules, macromolecules, nanoparticles, EVs and nucleic acids) into various materials. 16 The first example of polymer science is that Henri Braconnot derivatized naturally occurring cellulose into celluloids and cellulose acetate in 1830. In 1922, Hermann Staudinger first proposed that polymers are long-chain atoms held together by covalent bonds.…”

Section: Characteristics Of the Mn Partmentioning

confidence: 99%

“…Therefore, inorganic MNs are usually used to open pores on the skin to promote drug penetration in the form of hollow MNs or solid MNs coated with drugs on their surfaces. 16 As a pure element, silicon is the eighth most common in the universe and the second most common on Earth. 17 Moreover, it is an anisotropic crystal material whose characteristics depend on the relative orientation of the crystal lattice, yielding different elastic modulus values ranging from 50 to 180 GPa.…”

Section: Different Kinds Of Mn Materialsmentioning

confidence: 99%

“…3F) (stacking several layers of matrix onto a single tip), such as the two-stage needle body MN, whose different layers start to degrade at the same time, leading to the simultaneous release of multiple drugs and achieving drug pairing coaction. 16,27 More importantly, if the most terminal level of the MN is coated with metal plating to become an MN electrode, microelectronic technology can be successfully applied to MNs to promote drug release or assist in treatment by an electric current. As we know, there are open grooves on the surface of the fangs of the back-toothed snake.…”

Section: Different Shapes Of Mnsmentioning

confidence: 99%

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Modern microelectronics and microfluidics on microneedles

Han,

Li,

Chen

et al. 2023

Analyst

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show abstract

“…Therefore, inorganic MNs are usually used to open pores on the skin to promote drug penetration in the form of hollow MNs or solid MNs coated with drugs on their surfaces. 16…”

Section: Characteristics Of the Mn Partmentioning

confidence: 99%

Section: Characteristics Of the Mn Partmentioning

confidence: 99%

Section: Different Kinds Of Mn Materialsmentioning

confidence: 99%

Section: Different Shapes Of Mnsmentioning

confidence: 99%

See 2 more Smart Citations

Modern microelectronics and microfluidics on microneedles

Han,

Li,

Chen

et al. 2023

Analyst

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“…Besides, due to their excellent properties, microneedles can also be extended to other applications, such as insulin administration, vaccine delivery, dermatological treatment, blood sampling, and stem cell transplantation. [ 14–18 ] Over the years, various materials have been developed to meet the requirements of new‐generation microneedles, including hyaluronic acid (HA), methacrylate (HAMA), polyvinyl alcohol, and gelatin. [ 19–22 ] However, the main challenges facing these materials are poor mechanical capabilities and low flexible properties.…”

Section: Introductionmentioning

confidence: 99%

Advanced Silk Fibroin Biomaterials‐Based Microneedles for Healthcare

Wang

et al. 2023

Macromolecular Bioscience

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Microneedles are a promising transdermal drug delivery system that has the advantages of minimal invasiveness, painlessness, and on‐demand drug delivery compared with commonly used medical techniques. Natural resources are developed as next‐generation materials for microneedles with varying degrees of success. Among them, silk fibroin is a natural polymer obtained from silkworms with good biocompatibility, high hardness, and controllable biodegradability. These properties provide many opportunities for integrating silk fibroin with implantable microneedle systems. In this review, the research progress of silk fibroin microneedles in recent years is summarized, including their materials, processing technology, detection, drug release methods, and applications. Besides, the research and development of silk fibroin in a multidimensional way are analyzed. Finally, it is expected that silk fibroin microneedles will have excellent development prospects in various fields.

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Pathology‐Guided Cell Membrane‐Coated Polydopamine Nanoparticles for Efficient Multisynergistic Treatment of Periodontitis

Pan,

Zhong,

Lan

et al. 2024

Adv Funct Materials

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Nanodrug delivery systems (NDDSs) for the treatment of periodontitis remain a significant clinical challenge. The low biocompatibility, singular effect, and lack of disease specificity of conventional nanoparticles limit their biomedical application. Recent studies have highlighted the pivotal role of cell membrane‐coated nanotechnology in anti‐inflammatory strategies due to its improved biocompatibility and superior biointerface properties. Herein, combined with the pathological heterogeneity of periodontitis revealed by bioinformatics analysis, this study develops a novel cell membrane‐coated nanoparticle composed of two elements: minocycline‐loaded polydopamine nanoparticles (PM) and cRGD‐modified cell membrane (RCM). The in vitro results indicate that PM@RCM rescues impaired human periodontal ligament stem cells through antioxidant, anti‐ferroptosis, anti‐inflammatory, and pro‐osteogenic effects, and exhibits favorable antibacterial bioactivity. The in vivo studies further reveal that PM@RCM promotes periodontal tissue regeneration and remodeled periodontal homeostasis in periodontitis mice. Collectively, these findings highlight the unique pathological changes in periodontitis. Moreover, the novel NDDS developed in this study, which leverages the excellent natural properties of cell membrane‐coated nanotechnology and the versatility of nanoparticle cores, provides a promising strategy for the clinical treatment of periodontitis.

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Going below and beyond the surface: Microneedle structure, materials, drugs, fabrication, and applications for wound healing and tissue regeneration

Cited by 46 publications

References 193 publications

Modern microelectronics and microfluidics on microneedles

Modern microelectronics and microfluidics on microneedles

Advanced Silk Fibroin Biomaterials‐Based Microneedles for Healthcare

Pathology‐Guided Cell Membrane‐Coated Polydopamine Nanoparticles for Efficient Multisynergistic Treatment of Periodontitis

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