VoLuME 113 | dEcEMBEr 2018 Background Colorectal cancer (CRC) is the second leading cause of cancer death in men and women in the United States (US). Because of the effectiveness of CRC screening in reducing the incidence of and mortality associated with CRC, ample research has focused on improving adherence to screening for CRC [1-3]. The "de-escalation" of screening, meaning the cessation of routine preventive screening in older adults when benefits may be minimal or outweighed by potential risks, is an emerging concept that will have increasing importance as the US population ages [4, 5]. Optimizing appropriate use of screening colonoscopy in older adults improves care at the patient level, and importantly, at the system level, it may reduce costs and improve availability of colonoscopy for those in need of first-time screening. In 2008, the US Preventive Services Task Force (USPSTF) recommended that routine CRC screening stops after the age of 75 and that the decision to screen be individualized between the ages of 76 and 85 [6]. At that time, the USPSTF also recommended against routine screening in adults over 85 years old. Similarly, the US Multi-Society Task Force (USMSTF) on CRC recommends that persons who are up-to-date with screening and have negative prior screening tests be considered to stop screening at the age of 75 years [7]. In addition, the USMSTF recommends