Going Above and Beyond: A Tenfold Gain in the Performance of Luminescence Thermometers Joining Multiparametric Sensing and Multiple Regression

Abstract

Luminescence thermometry has substantially progressed in the last decade, rapidly approaching the performance of concurrent technologies. Performance is usually assessed through the relative thermal sensitivity, Sr, and temperature uncertainty, δT. Until now, the state‐of‐the‐art values at ambient conditions do not exceed maximum Sr of 12.5% K−1 and minimum δT of 0.1 K. Although these numbers are satisfactory for most applications, they are insufficient for fields that require lower thermal uncertainties, such as biomedicine. This has motivated the development of materials with an improved thermal response, many of them responding to the temperature through distinct photophysical properties. This paper demonstrates how the performance of multiparametric luminescent thermometers can be further improved by simply applying new analysis routes. The synergy between multiparametric readouts and multiple linear regression makes possible a tenfold improvement in Sr and δT, reaching a world record of 50% K−1 and 0.05 K, respectively. This is achieved without requiring the development of new materials or upgrading the detection system as illustrated by using the green fluorescent protein and Ag2S nanoparticles. These results open a new era in biomedicine thanks to the development of new diagnosis tools based on the detection of super‐small temperature fluctuations in living specimens.

Customized Luminescent Multiplexed Quick‐Response Codes as Reliable Temperature Mobile Optical Sensors for eHealth and Internet of Things

“…The comparison of S m with data reported in the literature is shown in Figure 3d. Such comparison includes the figures of merit from conventional spectroscopic [ 23,54–78 ] and mOptical sensing for IoT. [ 13,14,79–81 ] Noticeably, the figures of merit reported here are among the best ones in the literature, demonstrating the potential of color demultiplexing [ 45 ] to push luminescence thermometry toward IoT in a simple way.…”

“…In fact, the improvement of S r and δT values for physiological temperatures was recognized as one of the main challenges of the emerging field of luminescent micro‐ and nanothermometry [ 19 ][ 53 ][ 85 ] and a recent breakthrough in this direction reporting a tenfold improvement in S r and δT in that temperature range, reaching a world record of 50% K −1 and 0.05 K, respectively. [ 78 ]…”

“…In fact, the improvement of S r and δT values for physiological temperatures was recognized as one of the main challenges of the emerging field of luminescent micro-and nanothermometry [19][53] [85] and a recent breakthrough in this direction reporting a tenfold improvement in S r and δT in that temperature range, reaching a world record of 50% K À1 and 0.05 K, respectively. [78] In the next section, we will provide theoretical modeling for Δ 3 , allowing the temperature readout based on the R and G components to be independently verified through theoretical modeling. This permits to infer degradation of the medical adhesive as a smart label because the R and G coordinates arise from dU6Eu and dU6Tb inks, respectively.…”

Luminescence thermometry using sprayed films of metal complexes

“…4 These strides have been accompanied by the application of luminescence thermometry to study processes in the realm of the ultrafast 5 and ultrasmall, 6 contributing to augment our overall understanding of the natural world. The recently showcased use of advanced data treatment approaches, 7 along with the foreseeable implementation of artificial intelligence, is expected to push the boundaries of luminescence thermometry even further, providing researchers with a sophisticated and accurate tool in their investigations of physical, biological, and chemical systems. On the other hand, straightforward strategies that bring this technology closer to its widespread implementation in real-life and everyday applications are less developed.…”

Impact of Noise and Background on Measurement Uncertainties in Luminescence Thermometry

“…Newly developed thermometer materials are therefore often characterized and compared in terms of this parameter. 4 , 5 …”