Goatpox virus (G20-LKV) vaccine strain elicits a protective response in cattle against lumpy skin disease at challenge with lumpy skin disease virulent field strain in a comparative study

Zhugunissov, Kuandyk; Bulatov, Yerbol; Orynbayev, Mukhit; Kutumbetov, Lespek; Abduraimov, Ye.; Shayakhmetov, Ye.; Taranov, Dmitriy; Amanova, Zh T; Mambetaliyev, Muratbay; Absatova, Zh.; Azanbekova, Moldir; Khairullin, Berik; Zakaryа, Kunsulu; Tuppurainen, Eeva

doi:10.1016/j.vetmic.2020.108695

Cited by 31 publications

(24 citation statements)

References 31 publications

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“…Protection by sheeppox RM-65 strain at 10 times dose of small ruminants has been reported to be partial for LSD [16,21,[38][39][40]. Goatpox virus vaccines have been shown experimentally to be effective against LSD [7,41], but more data on the efficacy of these vaccine in the field need to be obtained.…”

Section: Discussionmentioning

confidence: 99%

Investigation of Post Vaccination Reactions of Two Live Attenuated Vaccines against Lumpy Skin Disease of Cattle

et al. 2021

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Lumpy skin disease virus (LSDV) causes an economically important disease in cattle. The only method for successful control is early diagnosis and efficient vaccination. Adverse effects of vaccination such as local inflammation at the injection site and localized or generalized skin lesions in some vaccinated animals have been reported with live vaccines. The aim of this work was to compare the safety of two lumpy skin disease (LSD) vaccine strains, Kenyan (Kn) Sheep and Goat Pox (KSGP O-240) and LSDV Neethling (Nt) strain, and to determine the etiology of the post-vaccination (pv) reactions observed in cattle. Experimental cattle were vaccinated under controlled conditions with Nt- and KSGP O-240-based vaccines, using two different doses, and animals were observed for 3 months for any adverse reactions. Three out of 45 cattle vaccinated with LSDV Nt strain (6.7%) and three out of 24 cattle vaccinated with Kn strain (12.5%) presented LSD-like skin nodules, providing evidence that the post-vaccination lesions may not be strain-dependent. Lesions appeared 1–3 weeks after vaccination and were localized in the neck or covering the whole body. Animals recovered after 3 weeks. There is a positive correlation between the vaccine dose and the appearance of skin lesions in vaccinated animals; at the 105 dose, 12% of the animals reacted versus 3.7% at the 104 dose. Both strains induced solid immunity when protection was measured by neutralizing antibody seroconversion.

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Section: Discussionmentioning

confidence: 99%

Investigation of Post Vaccination Reactions of Two Live Attenuated Vaccines against Lumpy Skin Disease of Cattle

et al. 2021

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“…In Kazakhstan, two locally produced vaccines based on GTPV (G2-LKW) and Niskhi SPPV strains were tested and compared in cattle. The GTPV strain provided full protection for experimental calves with an average protective index of 5.9 ± 0.0 infectious dose (ID) 50 /0.25 mL, compared to that of the SPPV vaccine group 5.3 ± 1.4 ID 50 /0.25 mL [ 48 ]. The GTPV vaccine was grown in LK cells, with an infectious activity of 5.50 ± 0.13 log TCID 50 /mL.…”

Section: Heterologous Vaccinesmentioning

confidence: 99%

Review: Vaccines and Vaccination against Lumpy Skin Disease

et al. 2021

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The geographical distribution of lumpy skin disease (LSD), an economically important cattle disease caused by a capripoxvirus, has reached an unprecedented extent. Vaccination is the only way to prevent the spread of the infection in endemic and newly affected regions. Yet, in the event of an outbreak, selection of the best vaccine is a major challenge for veterinary authorities and farmers. Decision makers need sound scientific information to support their decisions and subsequent actions. The available vaccine products vary in terms of quality, efficacy, safety, side effects, and price. The pros and cons of different types of live attenuated and inactivated vaccines, vaccination strategies, and associated risks are discussed. Seroconversion, which typically follows vaccination, places specific demands on the tools and methods used to evaluate the effectiveness of the LSD vaccination campaigns in the field. We aimed to give a comprehensive update on available vaccines and vaccination against LSD, to better prepare affected and at-risk countries to control LSD and ensure the safe trade of cattle.

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“…Although many countries have experienced the outbreak of LSD, but which strain or variants will be the perfect match for vaccine production is remained as a debatable issue (Ayelet et al., 2013; Ben‐Gera et al., 2015). Some recent articles claimed the potentiality of vaccine candidates for LSD prevention (Klement et al., 2020; Wolff et al., 2020; Zhugunissov et al., 2020). In contrast, vaccine strains were also found during the disease outbreak in Russia which raised further doubts on the vaccine candidate and its efficacy (Kononov et al., 2019).…”

Section: Introductionmentioning

confidence: 99%

Lumpy skin disease outbreak in cattle population of Chattogram, Bangladesh

Hasib

Islam

Das

et al. 2021

Veterinary Medicine & Sci

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Background Lumpy skin disease (LSD) is an important viral disease causing significant economic losses in commercial livestock production. In mid‐2019, an outbreak of LSD has been reported in cattle population from different parts of Bangladesh including Chattogram division. A cross‐sectional surveillance study was undertaken from August 2019 to December 2019 to investigate the prevalence and associated risk factors of LSD in cattle in Chattogram district. Methods A total of 3,327 cattle from 19 commercial farms were examined for the LSD specific skin lesions and associated risk factors. A total of 120 skin biopsies were collected from the suspected animal for the confirmation of the disease using molecular detection and histopathological examination. Partial genome sequencing and phylogenetic analyses were performed on selected viral isolates. Results The overall clinical prevalence of LSD in the study population was 10% (95% confidence interval [CI]: 9.4%–11%) where the highest farm level outbreak frequency was 63.33% (95% CI: 45.51%–78.13%) and the lowest 4.22% (95% CI: 3.39%–5.25%). Crossbred and female cattle showed a significantly higher prevalence of the disease compared to their counterparts. Introduction of new animals in farms was found to be one of the most significant risk factors in the transmission of the disease. All suspected skin biopsies were positive for LSD virus (LSDV) infection with granulomatous and pyogranulomatous dermatitis was revealed on histopathology. Phylogenetic analysis based on the inverted terminal repeat region of the LSDV gene suggested that the locally circulating strain was closely related to the strains isolated from the Middle East and North African countries. Conclusions The data generated in this study would be beneficial to the field veterinarians and animal health decision makers in the country as well as it will aid in taking appropriate measures to prevent further relapse or outbreak of this disease in future.

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Goatpox virus (G20-LKV) vaccine strain elicits a protective response in cattle against lumpy skin disease at challenge with lumpy skin disease virulent field strain in a comparative study

Cited by 31 publications

References 31 publications

Investigation of Post Vaccination Reactions of Two Live Attenuated Vaccines against Lumpy Skin Disease of Cattle

Investigation of Post Vaccination Reactions of Two Live Attenuated Vaccines against Lumpy Skin Disease of Cattle

Review: Vaccines and Vaccination against Lumpy Skin Disease

Lumpy skin disease outbreak in cattle population of Chattogram, Bangladesh

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