2018
DOI: 10.6061/clinics/2018/e327
|View full text |Cite
|
Sign up to set email alerts
|

Goal-directed therapy in patients with early acute kidney injury: a multicenter randomized controlled trial

Abstract: OBJECTIVES:Acute kidney injury is associated with many conditions, and no interventions to improve the outcomes of established acute kidney injury have been developed. We performed this study to determine whether goal-directed therapy conducted during the early stages of acute kidney injury could change the course of the disease.METHODS:This was a multicenter prospective randomized controlled study. Patients with early acute kidney injury in the critical care unit were randomly allocated to a standard care (co… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1
1

Citation Types

0
13
0

Year Published

2019
2019
2022
2022

Publication Types

Select...
5
2

Relationship

2
5

Authors

Journals

citations
Cited by 10 publications
(13 citation statements)
references
References 32 publications
0
13
0
Order By: Relevance
“…Considering data from the literature, we assumed a renal complication rate of 15% in high-risk surgical patients [4,7,12]. Therefore, we estimated that at least 1,000 patients would be required to conduct the study with the inclusion of fteen explanatory variables in a robust logistic regression model, with 28-day mortality as the dependent variable.…”
Section: Discussionmentioning
confidence: 99%
See 2 more Smart Citations
“…Considering data from the literature, we assumed a renal complication rate of 15% in high-risk surgical patients [4,7,12]. Therefore, we estimated that at least 1,000 patients would be required to conduct the study with the inclusion of fteen explanatory variables in a robust logistic regression model, with 28-day mortality as the dependent variable.…”
Section: Discussionmentioning
confidence: 99%
“…The subsequent rupture of intercellular junctions leads to the release of cells into the tubular lumen and to polarity loss of the transmembrane ion channel. It is expected that, in many cases, simply restoring the circulating volume does not improve the results and may be counterproductive [4,5]. Elevated intratubular pressure decreases glomerular ltration and activation of tubuloglomerular feedback, with consequent preglomerular vasoconstriction, which leads to an additional reduction in glomerular ltration.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Whether the results seen in animal pre-clinical models can be repeated in humans has been discussed previously [37,38]. The promising results of many therapeutics seen in animal AKI models [39][40][41][42][43][44], were unable to be repeated in AKI patients [11][12][13][14][15][16][17][18]45]. This has been explained by numerous factors including the failure of pre-clinical studies to model AKI accurately.…”
Section: Methods Of Aki Induction In Animal Modelsmentioning
confidence: 99%
“…ClinVar was recently found to be missing a large number of hearing impairment variants that primarily affect individuals of African ancestry 52 , likely indicative of a broader pattern. For variant predictors, this bias will lead to greater reliance on European ancestry variants and European genetic context, producing less accurate classification of IEM and PGX variants in other ancestries (e.g., African ancestry), which would only compound existing injustice in healthcare access for underrepresented populations 53,54 . Disparity in ancestry representation is especially stark in data sources for Genome Wide Association Studies (GWAS), where European ancestry disproportionately represents 81% of the data set population 48 .…”
Section: Ethical Considerations In Rare Variant Interpretationmentioning
confidence: 99%