GnRH antagonist-induced inhibition of the premature LH surge increases pregnancy rates in IUI-stimulated cycles. A prospective randomized trial

Allegra, Adolfo; Marino, Angelo; Coffaro, Francesco; Scaglione, Piero; Sammartano, Francesca; Rizza, Giovanni Manca; Volpes, Aldo

doi:10.1093/humrep/del337

Cited by 66 publications

(92 citation statements)

References 35 publications

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“…The mean value obtained in the study group was 1.65 ± 0.95, and in the control group the mean was 1.94 ± 0.98, with no statistical difference between the two (p = 0.203). In study conducted by Allegra et al [9], the number of mature follicles on the day of trigger was similar in the two groups. In another study conducted by Lambalk et al [13], there was no statistically significant difference in the number of mature follicles in the two groups.…”

Section: Mild Ovarian Hyperstimulation (Moh) Is Defined As the Adminimentioning

confidence: 64%

“…Study conducted by Allegra et al [9] did not show any difference in the incidence of OHSS in patients using cetrorelix and those who did not. There was no case of OHSS in either group.…”

Section: Mild Ovarian Hyperstimulation (Moh) Is Defined As the Adminimentioning

confidence: 78%

“…Study conducted by Checa et al [17] showed increased endometrial thickness in GnRH antagonist group as compared to the control group. Studies conducted by Lee et al [8], Graziano et al [16], Allegra et al [9] and Steward et al [14] did not show significant difference between endometrial thicknesses in the two groups. Kolibianakis et al [18] reported dysfunctional endometrium in IVF antagonist cycles.…”

Section: Mild Ovarian Hyperstimulation (Moh) Is Defined As the Adminimentioning

confidence: 82%

“…In the study conducted by Allegra et al [9], the mean duration of GnRH antagonist was 3.5 ? 0.8, and in study conducted by Cantineau et al, it was 2.2 days.…”

Section: Mild Ovarian Hyperstimulation (Moh) Is Defined As the Adminimentioning

confidence: 89%

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Evaluation of Role of GnRH Antagonist in Intrauterine Insemination (IUI) Cycles with Mild Ovarian Hyperstimulation (MOH): A Prospective Randomised Study

Wadhwa

Khanna

Gupta

et al. 2016

J Obstet Gynecol India

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Aims and Objective To evaluate the role of GnRH antagonist in prevention of premature LH surge and increasing pregnancy rates in IUI cycle with mild ovarian hyperstimulation (MOH). Study Design Prospective parallel, randomised controlled study. Material and Methods Couples diagnosed with unexplained, male factor subfertility and with one or both tubes patent were randomised to receive either a GnRH antagonist (study group) or no intervention (control group 123 women were treated with clomiphene citrate (D3-D7) followed by HMG. A GnRH antagonist was added when one or more follicles of 16 mm diameter or more were visualised in the study group. When at least one follicle reached a size of C18 mm, ovulation was induced by hCG injection. A single IUI was performed 36 h later. The primary outcome was premature LH surge and pregnancy rate. The secondary outcomes were the amount of gonadotropins used, duration of use of GnRH antagonist and incidence and severity of OHSS. Results A total of seventy patients attending the infertility clinic in the outpatient department of Obstetrics and Gynecology, of a tertiary care centre, were recruited in the study which was carried out from August 2011 to March 2013. The study group included 34 women and 36 in the control arm. The incidence of premature LH surge was significantly lower in the antagonist group as compared to the control group 2.9 vs. 13.9 %, with a p value of \0.001. The clinical pregnancy rates were similar in both the groups 8.8 vs. 11.1 %, p value being 1.000. The amount of gonadotropins used in GnRH antagonist group was lower than in control group but not statistically significant. Duration of GnRH antagonist was 1.85 ± 0.61 days in the study group. Conclusion The delayed administration of GnRH antagonists in MOH with IUI cycles when follicle size is C16 mm is beneficial in terms of preventing the occurrence of premature LH surge but with no improvement in pregnancy rates.

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Section: Mild Ovarian Hyperstimulation (Moh) Is Defined As the Adminimentioning

confidence: 64%

“…Study conducted by Allegra et al [9] did not show any difference in the incidence of OHSS in patients using cetrorelix and those who did not. There was no case of OHSS in either group.…”

Section: Mild Ovarian Hyperstimulation (Moh) Is Defined As the Adminimentioning

confidence: 78%

Section: Mild Ovarian Hyperstimulation (Moh) Is Defined As the Adminimentioning

confidence: 82%

“…In the study conducted by Allegra et al [9], the mean duration of GnRH antagonist was 3.5 ? 0.8, and in study conducted by Cantineau et al, it was 2.2 days.…”

Section: Mild Ovarian Hyperstimulation (Moh) Is Defined As the Adminimentioning

confidence: 89%

See 2 more Smart Citations

Evaluation of Role of GnRH Antagonist in Intrauterine Insemination (IUI) Cycles with Mild Ovarian Hyperstimulation (MOH): A Prospective Randomised Study

Wadhwa

Khanna

Gupta

et al. 2016

J Obstet Gynecol India

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“…Authors claiming increased pregnancy rates with antagonist use in IUI cycles proposed the mechanism of higher number of mature follicles which is a result of not scaring of premature luteinization (12) . Decreased incidence of premature luteinization may has a direct positive effect on pregnancy rates (17) .…”

Section: Premature Lh Surge and Pregnancy Ratesmentioning

confidence: 99%

THE USE OF GnRH ANTAGONISTS IN OVARIAN STIMULATION FOR INTRAUTERINE INSEMINATION

Işıkoğlu¹

2013

J Turk Soc Obstet Gynecol

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Agents for ovarian stimulation for intrauterine insemination (IUI) in ovulatory women with infertility

Cantineau

Rutten

Cohlen

2021

Cochrane Database of Systematic Reviews

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GnRH antagonist-induced inhibition of the premature LH surge increases pregnancy rates in IUI-stimulated cycles. A prospective randomized trial

Abstract: The use of GnRH antagonist in COS/IUI cycles improves pregnancy rate, preventing the premature LH rise and luteinization.

Cited by 66 publications

References 35 publications

Evaluation of Role of GnRH Antagonist in Intrauterine Insemination (IUI) Cycles with Mild Ovarian Hyperstimulation (MOH): A Prospective Randomised Study

Evaluation of Role of GnRH Antagonist in Intrauterine Insemination (IUI) Cycles with Mild Ovarian Hyperstimulation (MOH): A Prospective Randomised Study

THE USE OF GnRH ANTAGONISTS IN OVARIAN STIMULATION FOR INTRAUTERINE INSEMINATION

Agents for ovarian stimulation for intrauterine insemination (IUI) in ovulatory women with infertility

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