GnRh Agonist Treatment Improves Implantation and Pregnancy Rates of Frozen–Thawed Embryos Transfer

Abstract

Objective To study the effect of GnRh agonist administration prior to estrogen-progesterone preparation of the endometrium on the implantation rate in frozen-thawed embryo transfer (FET) cycles in infertile patients treated with IVF/ICSI.Design Prospective controlled study. Setting Private center in Alexandria, Egypt. Patients Patients undergoing frozen-thawed embryo transfer FET. Intervention(s) Patients were divided into two groups, A and B. Group A patients consisted of 110 patients (110 cycles) who received daily subcutaneous injections of 0.1 mg of the GnRh agonist triptorelin starting from the mid-luteal phase of the cycle preceding the actual FET cycle. The dose was reduced to 0.05 mg from the second day of the cycle when daily oral estradiol valerate 6 mg was also started. Daily vaginal supplementation of micronized progesterone 400 mg b.d. was started after 12 days when the GnRh agonist was also stopped. Frozen-thawed embryos were transferred on day ? 1 of their chronological age and when the endometrium reached 12 mm in thickness. Group B consisted of 100 patients (100 cycles) 123 who started daily estradiol valerate 6 mg administration from the second day of the FET cycle and followed the same regimen but without prior treatment with triptorelin. Main Outcome Measures Implantation and pregnancy rates were compared among the two groups.Results There was a significant increase in implantation rate in the GnRh agonist group (group A) compared to the estrogen and progesterone only group (group B) (44.1 vs. 21.1 %; P = 0.002*). The pregnancy rate was also significantly higher in group A compared to group B (65.5 vs. 42 %, P = 0.013*).Conclusions GnRh agonist administration during endometrial preparation for FET increases the implantation and pregnancy rates.

Effects of artificial cycles with and without gonadotropin-releasing hormone agonist pretreatment on frozen embryo transfer outcomes

“…Several studies claimed no difference in pregnancy outcomes between HRT and HRT with GnRHa pretreatment, 7 – 9 and other prospective studies showed that pregnancy outcomes were significantly improved by GnRHa pretreatment in HRT cycles. 10 , 11 We therefore retrospectively analyzed the outcomes of patients treated with FET cycles in our reproductive center and compared outcomes between HRT and HRT + GnRHa cycles.…”

Uterus Size May Affect Reproductive Outcome in Women with Adenomyosis After Gnrh- Agonist Pretreatment Undergoing Frozen Embryo Transfer Cycles: A Retrospective Cohort Study

“…In a study by Niu et al [13], clinical pregnancy, implantation, and ongoing pregnancy rates were signi cantly higher in women who were pretreated with GnRH-a than in those who were not. Hebisha et al [14] reported a signi cant increase in the implantation and pregnancy rates when GnRH-a was administered prior to estrogen-progesterone preparation of the endometrium in FET compared to when it was not. These studies indicate some bene cial effects of GnRH-a therapy in women with adenomyosis, including a potential for improved implantation.…”

Hormone Replacement Therapy With GnRH Agonist Pretreatment Improves Pregnancy Outcomes in Patients With Previous Intrauterine Adhesions: a Retrospective Study

“…Moreover, selective FET was reported to have better pregnancy outcomes than fresh ET in thin endometrium [9]. Proper endometrial preparation plays a key role to maximize IVF success rate and improve pregnancy results [10][11][12]. Therefore, we conducted a retrospective study to explore whether there is a best endometrial preparation protocol for IUAs.…”