Gneyulins A and B, Stilbene Trimers, and Noidesols A and B, Dihydroflavonol-C-Glucosides, from the Bark of Gnetum gnemonoides

Abstract

Gneyulins A (1) and B (2), two new stilbene trimers consisting of oxyresveratrol constituent units, and noidesols A (3) and B (4), two new dihydroflavonol-C-glucosides, were isolated from the bark of Gnetum gnemonoides. The structures and configurations of 1-4 were elucidated on the basis of 2D NMR correlations and X-ray analysis. Gneyulins A (1) and B (2) showed inhibition of Na(+)-glucose transporters (SGLT-1 and SGLT-2).

Cuspidans A and B, Two New Stilbenoids from the Bark of <i>Gnetum cuspidatum</i>

“…Recently, we have reported the isolation of two new oxyresveratrol trimers, gneyulins A and B, from the bark of G. gnemonoides showed the inhibitory activity against Na + -glucose cotransporter (SGLT). 9) In our search for structurally and biological interesting compounds from tropical plants found in Malaysia, 10,11) two new stilbenoids, cuspidans A (1) and B (2) were isolated from the bark of Gnetum cuspidatum. We report here the isolation and structure elucidation of cuspidans A (1) and B (2) as well as their in vitro cell growth inhibitory activities against human promyelocytic leukemia (HL-60) cells.…”

Molecular mechanism of vSGLT inhibition by gneyulin reveals antiseptic properties against multidrug-resistant gram-negative bacteria

“…Both molecules, known under the names gneyulin A and gneyulin B, can be extracted from Gnetum gnemonoides, a kind of tropical lianas. Substances isolated from Gnetum species, belonging to the group of stilbenes, are already shown to reveal antioxidant, antimicrobial, and some inhibitory activities [18].…”

SGLT inhibitors as antidiabetic agents: a comprehensive review

“…115 Compound (65) was identied as the most potent compound among the constituents of the bark of the tree Acer nikoense, isolated by Morita et al Compound (65) showed IC 50 values of 26 and 43 mM against SGLT1 and SGLT2, respectively. 116 Natural stilbenes were isolated from the dried bark of the tree Gnetum gnemonoides by Shimokawa et al Among these compounds, gneyulin A (66) was found to be the most active inhibitor against both SGLT1 and SGLT2, with IC 50 values of 27 and 25 mM, respectively (Table 3). 116…”