GM-CSF and GM-CSF receptor have regulatory role in transforming rat mesenteric mesothelial cells into macrophage-like cells

Katz, Sándor; Zsiros, Viktória; Dóczi, Nikolett; Szabó, Arnold; Biczo, Adam; Kiss, Anna L.

doi:10.1007/s00011-016-0967-5

Cited by 12 publications

(11 citation statements)

References 30 publications

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“…Far from being static actors, they are supposed to play a dynamic role in homeostasis and immunoregulation by synthesizing and secreting immune mediator-like factors [14]. Furthermore, it has been proposed, based on animal models, that under inflammatory stimuli, mesothelial cells can express macrophage markers and possibly transdifferentiate into phago-cytic macrophage-like cells [15,16]. The extensive emperipolesis of malignant lymphoid T cells by mesothelial cells seems to support this preclinical evidence in our case.…”

Section: Discussionsupporting

confidence: 71%

Extensive Emperipolesis of Neoplastic Lymphocytes by Mesothelial Cells in Pleural Effusion Cytology in a Case of a Mediastinal T-Cell Lymphoblastic Lymphoma: A Rare but Diagnostically Useful Phenomenon

et al. 2019

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Emperipolesis is a rare cell-in-cell phenomenon and a pathognomonic sign of Rosai-Dorfman disease. • Nonspecific lymphocyte rich pleural benign effusions are relatively common and mainly composed of reactive T lymphocytes. Novel Insights• Emperipolesis of lymphocytes by mesothelial cells is a rare finding that seems to be specific to both Band T-cell lymphomas in the context of lymphocyte rich pleural effusion. AbstractEmperipolesis is a biological process defined by the presence of an intact cell within the cytoplasm of another cell. In pleural fluid cytology, the phenomenon is very rare but has already been described in B-cell lymphoma. Here, we report the first case of a T-cell lymphoma diagnosed on a pleural fluid exhibiting extensive emperipolesis of tumor cells by mesothelial cells. Additionally, in order to evaluate the prevalence of emperipolesis in lymphocyte rich pleural effusion cytology, we reviewed cases from our archive, including cases with lymphoma and cases with reactive T-lymphocyte rich effusion.

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Section: Discussionsupporting

confidence: 71%

Extensive Emperipolesis of Neoplastic Lymphocytes by Mesothelial Cells in Pleural Effusion Cytology in a Case of a Mediastinal T-Cell Lymphoblastic Lymphoma: A Rare but Diagnostically Useful Phenomenon

et al. 2019

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“…Granulocyte-macrophage colony-stimulating factor (GM-CSF) was once reported being able to change mesothelial cells into macrophage-like cells by an autocrine pattern [ 77 ]. GM-CSF gene expression was also associated with macrophage densities in the arterial wall [ 78 ].…”

Section: Immune Cell Infiltration In Aaamentioning

confidence: 99%

Modulation of Immune-Inflammatory Responses in Abdominal Aortic Aneurysm: Emerging Molecular Targets

Bai

et al. 2018

Journal of Immunology Research

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Abdominal aortic aneurysm (AAA), a deadly vascular disease in human, is a chronic degenerative process of the abdominal aorta. In this process, inflammatory responses and immune system work efficiently by inflammatory cell attraction, proinflammatory factor secretion and subsequently MMP upregulation. Previous studies have demonstrated various inflammatory cell types in AAA of human and animals. The majority of cells, such as macrophages, CD4+ T cells, and B cells, play an important role in the diseased aortic wall through phenotypic modulation. Furthermore, immunoglobulins also greatly affect the functions and differentiation of immune cells in AAA. Recent evidence suggests that innate immune system, especially Toll-like receptors, chemokine receptors, and complements are involved in the progression of AAAs. We discussed the innate immune system, inflammatory cells, immunoglobulins, immune-mediated mechanisms, and key cytokines in the pathogenesis of AAA and particularly emphasis on a further trend and application of these interventions. This current understanding may offer new insights into the role of inflammation and immune response in AAA.

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“…We found that during inflammation-induced EMT mesenteric mesothelial cells start to express macrophage markers (OX43, ED1) as well [1,13]This observation raised the possibility that mesothelial cells might transdifferentiate into macrophage-like cells [14]. This idea seemed to be even more likely since our previous data showed that under inflammatory stimuli the number of macrophages appearing in the peritoneal cavity dramatically increased [15].…”

Section: Inflammation Induced Emt Transdifferentiates Mesothelial Celmentioning

confidence: 60%

Cellular and molecular events of inflammation induced transdifferentiation (EMT) and regeneration (MET) in mesenteric mesothelial cells

Zsiros

Kiss

2020

Inflamm. Res.

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In this review we summarize the cellular and molecular events of inflammation induced epithelial-to-mesenchymal (EMT) and mesothelial-to-macrophage transition (MET) during regeneration. Since the receptor transmits the environmental stimulus, downregulating or upregulating the process on an epigenetic level, the intracellular localization of receptors (signaling organelles: early endosomes or lysosomal degradation: late endosomes) plays a crucial role in the signaling events regulating inflammation and regeneration. Therefore, we focused on the internalization of the receptors as well as the intracellular compartmentalization of signaling molecules during EMT and MET. The review draws the reader’s attention to the plasticity of mesothelial cells and supports the idea that during inflammation an ambient macrophage population might derive from mesothelial cells.

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GM-CSF and GM-CSF receptor have regulatory role in transforming rat mesenteric mesothelial cells into macrophage-like cells

Cited by 12 publications

References 30 publications

Extensive Emperipolesis of Neoplastic Lymphocytes by Mesothelial Cells in Pleural Effusion Cytology in a Case of a Mediastinal T-Cell Lymphoblastic Lymphoma: A Rare but Diagnostically Useful Phenomenon

Extensive Emperipolesis of Neoplastic Lymphocytes by Mesothelial Cells in Pleural Effusion Cytology in a Case of a Mediastinal T-Cell Lymphoblastic Lymphoma: A Rare but Diagnostically Useful Phenomenon

Modulation of Immune-Inflammatory Responses in Abdominal Aortic Aneurysm: Emerging Molecular Targets

Cellular and molecular events of inflammation induced transdifferentiation (EMT) and regeneration (MET) in mesenteric mesothelial cells

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