Gm allogenotype distribution and lack of HLA‐DR, Gm interaction in SLE and CREST/PSS

Jazwinska, Elizabeth C.; Dunckley, H.; Gatenby, Paul A.; Serjeantson, S. W.

doi:10.1038/icb.1989.39

Immunol Cell Biol

1989

DOI: 10.1038/icb.1989.39

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Gm allogenotype distribution and lack of HLA‐DR, Gm interaction in SLE and CREST/PSS

Elizabeth C. Jazwinska

H. Dunckley

Paul A. Gatenby

et al.

Abstract: Summary The distribution of Gm allogenotypes (Gm allotypes identified by IgCH restriction fragment length polymorphism (RFLP) analysis) was compared in 66 systemic lupus erythematosus (SLE) patients, 38 CREST/PSS patients and 56 healthy controls. Patient/control comparison showed that Gm homozygosity was increased in the CREST/PSS group (/'<0-05) but not in the SLE group. HLA-DR5 is significantly increased in frequency in this series of CREST/PSS patients compared to controls (f<0-001), and log linear regressi… Show more

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Cited by 3 publications

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“…The association of imrnunoglohulin allotypes with susceptibility to systemic lupus erythematosus (SLE) has been reported in different ethnic populations (1-4). A Gm allotype relationship with SLE was found, in association with HLA antigens, in patients in Hungary and Australia (3,4); other studies have demonstrated no such Gm/HLA association (5). In Caucasian SLE patients, we have observed an increased frequency of Gm 1,3,17;5,13,21 and a decreased frequency of Gm 3;5,13 (the latter was thus associated with resistance to the disease) (1).…”

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Immunoglobulin heavy chain constant‐region gene polymorphism in systemic lupus erythematosus

Kumar

Martinez‐Tarquino

Maria‐Forte

et al. 1991

Arthritis & Rheumatism

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Systemic lupus erythematosus (SLE) is associated with immunoglobulin allotypes in several ethnic groups.In this study, we investigated the association of a Bst EII immunoglobulin heavy chain constant-region gene restriction fragment length polymorphism with SLE in patients from the US and Mexico. A 3-kb restriction fragment was observed with significantly decreased frequency in randomly selected Mexican SLE patients and in Mexican SLE patients in multiplex families. However, no such association was observed in SLE patients from the US. Thus, the absence of a 3.0-kb Bst EII restriction fragment from immunoglobulin heavy chain constant-region genes provides a marker for SLE in Mexican individuals.

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mentioning

confidence: 99%

Immunoglobulin heavy chain constant‐region gene polymorphism in systemic lupus erythematosus

Kumar

Martinez‐Tarquino

Maria‐Forte

et al. 1991

Arthritis & Rheumatism

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FcγRII restriction fragment length polymorphism (RFLP): analysis in systemic lupus erythematosus and scleroderma and evidence of an alpha gene duplication

Jazwinska¹,

Olive²,

Hogarth

et al. 1991

Clinical and Experimental Immunology

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SUMMARY The characteristic finding of high levels of circulating immune complexes in patients with the autoimmune connective tissue diseases systemic lupus erythemalosus (SLE) or scleroderma has raised the possibility that these patients may have a primary defect in immune complex clearance. The Fc receptor for IgG (FcγR) plays a central role in the phagocytosis of antibody complexes. We have analysed FcγR (type II) RFLPs identified in TaqI‐and MspI‐restrictcdgenomic DNAand found that their distribution in SLE and selerodenna did not differ significantly from controls. Hybridization with specific regions of the FcγRII cDNA clone indicate that part of the FcγRIIα locus is duplicated in some individuals. A further FcγRII gene has recently been identified (FcγRIIα). This gene shows > 95% homology with FcγRIIα and may thus be the candidate gene for the apparant α duplication seen in some individuals. It is possible that an individual may possess one. two, three or four TaqI FcγRIIα/α′alleles. correlating with incidence and numerical heterogeneity in FcγRIIα and α′. The physiological effects of this numerical heterogeneity remain to be investigated.

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Review: Genetics of systemic lupus erythematosus

Schur

1995

Lupus

112

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IntroductionThe genetics of systemic lupus erythematosus (SLE) was last reviewed in depth in 1992.1.2 The premise that genetic factors are involved in SLE was originally based on the observations of an increased frequency of SLE in identical twins 3-6 and among first degree relatives 7-1 1 and an increased frequency of immune abnormalities in relatives of patients with SLE.12-31 However, no single gene defect has been discovered as the cause of SLE. In fact, based on mathematical models it has been postulated that at least four genes are implicated in the cause of SLE. 32 Subsequent to the discovery that a number of autoimmune diseases and immune abnormalities are influenced by genetic factors, it seemed logical to examine genes in patients with SLE. Resultant numerous studies examined the frequency of genes associated with classical components of the immune system (MHC, complement, T cell receptor (TCR) and immunoglobulins) in patients with SLE. This manuscript reviews the possible role of these and other genetic factors in SLE with particular emphasis on studies from different racial and ethnic groups in various countries. The dataThe associations between SLE and various MHC loci and alleles in different countries is given in Table 1. The B8-DR3 haplotype is associated with SLE in Caucasians: in Australia, among English-Canadians, in Czechoslovakia, England, France, Germany, Hungary, Italy, Scandinavia and Switzerland. Both DR2 and DR3 (haplotypes) are associated with SLE in Bulgaria, Russia and the USA. SLE is also associated with DR2 in Greece, with DQ6 among French-Canadians, with DR4 among Indians, with the B 18-DR3 haplotype in Spain and with no DR in Italy. There was a stronger association with the B8/DR3 associated extended haplotype (Al-B8-C4AO-DR3-DQW2) than any of its alleles.33,34,54.69,70.73.112,115 SLE in Afro-Americans is associated with both DR2 and DR3 in the USA; with DR2 in Toronto and in South African coloured people; and with no DR in the USA and the French West Indies. It should be noted that SLE is not seen in West and Central Africa.213 SLE in the Orient is associated with DR2 and DR3 in China and with DR2 in Japan, Korea and Singapore. There was a stronger association with the extended DRB 1 * 1501 haplotype (DRB I -DRB5-DQA I -DQB I) than any of its alleles in Japan and Korea.SLE has also been associated with sharing of HLA haplotypes in the parents of SLE patients in the USA. 214 SLE in patients in Central Europe was not associated with homozygosity in class II MHC loci/haplotypes.'-' S SLE has also been associated with complement components deficiencies. Heterozygous deficiency of the complement component C4A has been noted frequently in SLE patients in Australia, among English-Canadians, in England, Germany and Scandinavia; and in some studies in patients with SLE in China, France, Japan and the USA. There is no increased frequency of C4A deficiency in SLE patients in Taiwan, Spain and in French-Canadians. Furthermore the frequency of SLE is at least 50% in patients with homozygou...

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Gm allogenotype distribution and lack of HLA‐DR, Gm interaction in SLE and CREST/PSS

Cited by 3 publications

References 13 publications

Immunoglobulin heavy chain constant‐region gene polymorphism in systemic lupus erythematosus

Immunoglobulin heavy chain constant‐region gene polymorphism in systemic lupus erythematosus

FcγRII restriction fragment length polymorphism (RFLP): analysis in systemic lupus erythematosus and scleroderma and evidence of an alpha gene duplication

Review: Genetics of systemic lupus erythematosus

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