Glyprolines and Semax Prevent Stress-Induced Microcirculatory Disturbances in the Mesentery

Kopylova, G. N.; Смирнова, Е. А.; Sanzhieva, L. Ts.; Umarova, B. A.; Lelekova, T. V.; Samonina, G. E.

doi:10.1023/b:bebm.0000017087.90585.a9

Cited by 6 publications

(8 citation statements)

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“…Vital microscopy of mesenteric microcirculatory bed was performed at various stages of peritonitis (30 min and 2, 6, and 18 h after administration of thioglycollate) [3].…”

Section: Methodsmentioning

confidence: 99%

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The role of protective effects of proline-containing peptides (PGP, PG, and GP) in contractile dysfunction of mesenteric lymphatic vessels in rats with experimental acute peritonitis

et al. 2006

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The development of acute peritonitis in rats induced by intraperitoneal injection of thioglycollate was accompanied by a decrease in contractile function of mesenteric lymphatic vessels and impaired response to norepinephrine. Administration of proline-containing peptides after induction of inflammation significantly decreased the severity of these disorders. Our results attest to the possibility of using peptides for the correction of mesenteric microcirculatory disturbances during inflammation.

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“…Vital microscopy of mesenteric microcirculatory bed was performed at various stages of peritonitis (30 min and 2, 6, and 18 h after administration of thioglycollate) [3].…”

Section: Methodsmentioning

confidence: 99%

“…Pretreatment with proline-containing peptides (PGP, PG, and GP) prevents the development of stress-induced microcirculatory disturbances [3,4].…”

mentioning

confidence: 99%

The role of protective effects of proline-containing peptides (PGP, PG, and GP) in contractile dysfunction of mesenteric lymphatic vessels in rats with experimental acute peritonitis

et al. 2006

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“…The function of these cells is characterized by a drastic increase in the level of secretory activity. We previously showed that injection of glyprolines before stress exposure significantly attenuated the stressogenic disorders in the rat mesenteric microcirculation [2]. Stabilization of mast cells by preinjection of ketotifene prevented stressinduced disorders in contractile activity of mesenteric lymph vessels and reduced stressogenic activation of mast cells [1].…”

Section: Resultsmentioning

confidence: 98%

“…We previously showed that injection of glyprolines before stress exposure significantly attenuated the stressogenic disorders in the rat mesenteric microcirculation [2]. Stabilization of mast cells by preinjection of ketotifene prevented stressinduced disorders in contractile activity of mesenteric lymph vessels and reduced stressogenic activation of mast cells [1]. Increased secretory activity of mast cells during inflammation suggested that the protective effect of PGP is mediated by inhibition of secretory activity of mast cells during inflammation-induced disorders of contractile activity of lymph vessels.…”

Section: Resultsmentioning

confidence: 98%

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Peptide correction of disorders in rat mesenteric microcirculatory system during inflammation

et al. 2007

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PGP peptide had a protective effect in contractile dysfunction of the rat mesenteric lymph vessels under conditions of inflammation, irrespective of the time of its injection (before or after inflammatory agent). The preventive effect of this peptide is largely determined by its capacity to prevent mast cells activation. PGP injected 2 h after induction of inflammation did not inhibit secretory activity of mast cells, which suggests other mechanisms of its therapeutic action.

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Effect of Acute and Moderate Repeated Stress on Disturbances in Reactivity of Mesenteric Lymphatic Vessels during Inflammation in Rats

et al. 2009

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We studied the effect of acute (single immobilization for 1 h) and repeated (daily immobilization for 1 min, 5 days) moderate stress on disturbances in contractility of mesenteric lymphatic vessels in rats with experimental peritonitis. Acute stress was shown to potentiate, while moderate repeated stress attenuate the effect of inflammatory stimulus. It can be hypothesized that moderate repeated stress improves adaptive capacities of the organism, which manifests in reduction or prevention of dysfunction in contractile activity of lymphatic vessels.

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Glyprolines and Semax Prevent Stress-Induced Microcirculatory Disturbances in the Mesentery

Cited by 6 publications

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The role of protective effects of proline-containing peptides (PGP, PG, and GP) in contractile dysfunction of mesenteric lymphatic vessels in rats with experimental acute peritonitis

The role of protective effects of proline-containing peptides (PGP, PG, and GP) in contractile dysfunction of mesenteric lymphatic vessels in rats with experimental acute peritonitis

Peptide correction of disorders in rat mesenteric microcirculatory system during inflammation

Effect of Acute and Moderate Repeated Stress on Disturbances in Reactivity of Mesenteric Lymphatic Vessels during Inflammation in Rats

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