Glypican-4 serum levels are associated with cognitive dysfunction and vascular risk factors in Parkinson’s disease
Lars Tatenhorst,
Fabian Maass,
Hannah Paul
et al.
Abstract:Glypicans are biomarkers for various pathologies, including cardiovascular disease, cancer and diabetes. Increasing evidence suggests that glypicans also play a role in the context of neurodegenerative disorders. Initially described as supporting functionality of synapses via glutamate receptors during CNS development, Glypican 4 (GPC-4) also plays a role in the context of dementia via tau hyperphosphorylation in Alzheimer’s disease, which is also a co-pathology in Parkinson’s disease dementia. However, clinic… Show more
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