Glypican 3 is a sensitive, but not a specific, marker for the diagnosis of yolk sac tumours

Preda, Ovidiu; Nicolae, Alina; Aneiros‐Fernández, José; Borda, Angela; Nogales, Francisco F.

doi:10.1111/j.1365-2559.2010.03735.x

Cited by 28 publications

(26 citation statements)

References 3 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Glypican-3 can be positive in embryonal carcinoma, choriocarcinoma, and teratoma, as well as in some non-germ cell tumors. 19,[39][40][41][42] ZBTB16, a transcription repressor, has been known to have a key role in normal spermatogenesis. 43 Its contribution to the pathogenesis of germ cell tumor and clinical value in the diagnosis of germ cell tumor, however, has not yet been investigated.…”

Section: Discussionmentioning

confidence: 99%

“…2,[13][14][15][16] In addition, their expression may be lost in metastases or after treatment. 17,18 Glypican-3 is a more recently identified sensitive marker for yolk sac tumor; 19,20 nevertheless, glypican-3 has also been reported in embryonal carcinoma, choriocarcinoma and teratoma. [18][19][20] Zinc finger and BTB domain containing 16 (ZBTB16), first identified in a patient with acute promyelocytic leukemia, is a zinc finger transcription factor belonging to the POZ-Krüppel family that binds to specific DNA sequences with its C-terminal zinc fingers and suppresses transcription by recruiting co-repressors with its aminoterminal POZ domain.…”

mentioning

confidence: 99%

“…17,18 Glypican-3 is a more recently identified sensitive marker for yolk sac tumor; 19,20 nevertheless, glypican-3 has also been reported in embryonal carcinoma, choriocarcinoma and teratoma. [18][19][20] Zinc finger and BTB domain containing 16 (ZBTB16), first identified in a patient with acute promyelocytic leukemia, is a zinc finger transcription factor belonging to the POZ-Krüppel family that binds to specific DNA sequences with its C-terminal zinc fingers and suppresses transcription by recruiting co-repressors with its aminoterminal POZ domain. 21,22 ZBTB16 affects diverse signaling pathways including cell cycle, differentiation, and programmed cell death pathways in hematopoietic cells and in solid tumors as well, [22][23][24][25] and is involved in major developmental and biological processes such as spermatogenesis and stem cell maintenance, hind limb formation, hematopoiesis, immune regulation, and oncogenesis.…”

mentioning

confidence: 99%

See 2 more Smart Citations

ZBTB16: a novel sensitive and specific biomarker for yolk sac tumor

Xiao

Unger

et al. 2016

Modern Pathology

View full text Add to dashboard Cite

Although the function of zinc finger and BTB domain containing 16 (ZBTB16) in spermatogenesis is well documented, expression of ZBTB16 in germ cell tumors has not yet been studied. The aim of this study was to investigate the immunohistochemical expression and diagnostic utility of ZBTB16 in germ cell tumors. A total of 67 adult germ cell tumors were studied (62 testicular germ cell tumors, 2 ovarian yolk sac tumors, 1 mediastinal yolk sac tumor, and 2 retroperitoneal metastatic yolk sac tumors). The 62 testicular primary germ cell tumors are as follows: 34 pure germ cell tumors (20 seminomas, 8 embryonal carcinomas, 2 teratomas, 1 choriocarcinoma, 1 carcinoid, and 2 spermatocytic tumors) and 28 mixed germ cell tumors (composed of 13 embryonal carcinomas, 15 yolk sac tumors, 15 teratomas, 7 seminomas, and 3 choriocarcinomas in various combinations). Thirty-five cases contained germ cell neoplasia in situ. Yolk sac tumor was consistently reactive for ZBTB16. Among the 15 testicular yolk sac tumors in mixed germ cell tumors, all displayed moderate to diffuse ZBTB16 staining. ZBTB16 reactivity was present regardless of the histologic patterns of yolk sac tumor and ZBTB16 was able to pick up small foci of yolk sac tumor intermixed/embedded in other germ cell tumor subtype elements. Diffuse ZBTB16 immunoreactivity was also observed in 2/2 metastatic yolk sac tumors, 1/1 mediastinal yolk sac tumor, 2/2 ovarian yolk sac tumors, 2/2 spermatocytic tumors, 1/1 carcinoid, and the spermatogonial cells. All the other non-yolk sac germ cell tumors were nonreactive, including seminoma (n = 27), embryonal carcinoma (n = 21), teratoma (n = 17), choriocarcinoma (n = 4), and germ cell neoplasia in situ (n = 35). The sensitivity and specificity of ZBTB16 in detecting yolk sac tumor among the germ cell tumors was 100% (20/20) and 96% (66/69), respectively. In conclusion, ZBTB16 is a highly sensitive and specific marker for yolk sac tumor.

show abstract

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

See 1 more Smart Citation

ZBTB16: a novel sensitive and specific biomarker for yolk sac tumor

Xiao

Unger

et al. 2016

Modern Pathology

View full text Add to dashboard Cite

show abstract

“…56 CHORIOCARCINOMA Pure nongestational choriocarcinoma is exceptionally rare in the ovary. Similar to dysgerminoma and EC, it represents more a testicular-type tumor, and its presence should prompt an analysis of the patient's genotype.…”

mentioning

confidence: 99%

“…Trophoblast stains strongly for cytokeratin, human chorionic gonadotropin, a-inhibin, CD10, and GLP3. 56,68 Human placental lactogen can identify the intermediate (extravillous) trophoblastic component. 69 …”

mentioning

confidence: 99%

Germ Cell Tumors of the Ovary: An Update

Nogales

Dulcey

Preda

2014

Archives of Pathology &Amp; Laboratory Medicine

Self Cite

View full text Add to dashboard Cite

Context.—The field of ovarian germ cell tumors (OGCTs) has remained relatively unchanged in the last 2 decades. However, the introduction of new stem cell pluripotency markers has provided a new understanding into the identification and taxonomy of OGCT types. New data have provided new insights into unusual teratoma-associated autoimmune disorders and the origin of gliomatosis peritonei. Objective.—To review the impact of new pluripotency markers in the diagnosis of malignant OGCT (MOGCT) and analyze new nomenclature proposals and clinicopathologic entities. Data Sources.—Ovarian germ cell tumors from routine material and expert consultation files at San Cecilio University Hospital, Granada, Spain, and the relevant literature were reviewed. Conclusions.—Although a correct diagnosis of MOGCT can often be made with histologic and classic immunohistochemical studies, the new immunohistochemical pluripotency markers give higher diagnostic accuracy. Germ cell tumors represent a caricature of the phases of normal embryonic differentiation from primordial germ and stem cells to extraembryonal and somatic tissue differentiation. Since every stage of differentiation and its related tumor type exhibit characteristic markers, the analysis of their expression facilitates tumor typing, thus complementing the use of classic antibodies. They also allow a more precise evaluation of the degree of immaturity in teratoma. The new term, primitive endodermal tumors, simplifies the understanding of the complex histology of the yolk sac tumor group, as this terminology encompasses its multiple endodermal differentiations. Recently described autoimmune encephalitis due to antibodies against the N-methyl-d-aspartate receptor has become the most frequent autoimmune disorder associated with ovarian teratoma.

show abstract

Ovary-II Germ Cell Tumors and Sex Cord Tumors

Cao

Snir

2021

Practical Gynecologic Pathology

View full text Add to dashboard Cite

Glypican 3 is a sensitive, but not a specific, marker for the diagnosis of yolk sac tumours

Cited by 28 publications

References 3 publications

ZBTB16: a novel sensitive and specific biomarker for yolk sac tumor

ZBTB16: a novel sensitive and specific biomarker for yolk sac tumor

Germ Cell Tumors of the Ovary: An Update

Ovary-II Germ Cell Tumors and Sex Cord Tumors

Contact Info

Product

Resources

About