Glypican-3 antibody functionalized Prussian blue nanoparticles for targeted MR imaging and photothermal therapy of hepatocellular carcinoma

Li, Zhenglin; Zeng, Yongyi; Zhang, Da; Wu, Ming; Wu, Lingjie; Huang, Aimin; Yang, Huanghao; Liu, Xiaolong; Liu, Jingfeng

doi:10.1039/c4tb00516c

Cited by 73 publications

(71 citation statements)

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“…Although targeting can also be achieved using small molecules, peptides, aptamers and other biomolecules [15], we focus in this section on the use of antibodies. Surface modifications of nanoparticle systems ranging from metal particles to polymer and micellar structures allows covalent attachment of antibodies via methods such as amide bonds using EDAC NHS chemistry [16][17][18], dopamine-mediated bonding [19], maleimide groups [20], disulfide bonds [21] and the use of a hydrazide alkyl linker [22]. Regardless of the linkage, the formation of a protein corona surrounding the nanoparticle is likely to take place, thereby blocking recognition of the functional groups.…”

Section: Targeting Tumor Cells With Antibodiesmentioning

confidence: 99%

Inorganic nanoparticles for biomedicine: where materials scientists meet medical research

et al. 2016

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Materials scientists have performed exceptional accomplishments in the design of various types of materials that can be directly used for biomedical research. In particular, nanomaterials (including plasmonic nanoparticles) have become forefront scaffolds for designing bioactive materials. The application of such materials in biomedicine however requires a directed design providing actuation and stability in a particularly complex environment such as living organisms. Enhanced diagnostic tools for diseases such as cancer and HIV are pursued, and in this context nanoparticles offer exclusive physicochemical features for accurate biosensing, as well as actuation. We discuss the biosensing capabilities of plasmonic nanoparticles, in connection with SERS imaging. Novel therapies based on local drug delivery and photothermal therapy activated by nanoparticles are being explored. These applications are briefly discussed in this article, considering the actual biological problems faced by materials scientists and highlighting the beneficial interactions between materials science and biomedicine, which lead to novel routes in biomedical research and practice.

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Section: Targeting Tumor Cells With Antibodiesmentioning

confidence: 99%

Inorganic nanoparticles for biomedicine: where materials scientists meet medical research

et al. 2016

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“…NPs can also be used to target the tumor stroma changing the tumor microenvironment from its pro-tumorigenic state to an antitumorigenic state. One study demonstrated the ability of nanoparticles to target the tumor endothelium and improve the anti-tumoral efficacy of paclitaxel, both in vivo and in vitro [27]. Another approach would be to target the macrophage because they are inherently phagocytic and may uptake nanoparticles either within the tumor or in the circulation and subsequently migrate towards to the tumor.…”

Section: Molecular Mechanism Of Nanoparticle-mediated Tumor Ablationmentioning

confidence: 99%

Old versus New – Tumor Ablation versus Tumor Nanoablation with Particular Emphasis on Liver Tumors

Spârchez¹,

Mocan²,

Radu³

2015

Recent Advances in Liver Diseases and Surgery

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Loco-regional treatments play a key role in the management of hepatocellular carcinoma HCC . Image-guided tumor ablation is recommended in patients with early-stage HCC when surgical options are precluded. Radiofrequency ablation is currently established as the standard method for local tumor treatment. Despite major advances in tumor ablation techniques the disease recurs in a high proportion of cases. " major limitation in its overall effectiveness is due to the difficulties of heating large tumors. Small regions of viable tumor may still remain even after apparently good tumor ablation by perfusion-mediated tissue cooling, preventing the whole tumor reaching a sufficient temperature for coagulation and necrosis. Moreover simple heating techniques have trouble discriminating between tumors and surrounding healthy tissues leading to many side effects. In order to overcome these major limitations numerous groups are investigating the use of energy-absorbing agents localized within tumor tissues to facilitate localized heating. " personal answer based on the review of the literature will be offered to the following questions NIR photothermal therapy, RF" with nanoparticles, or magnetic fluid hyperthermia for the long term management of HCC? How should we deliver nanoparticles systemically or directly intratumoral? "blation versus mild hyperthermia Pros and Cons in the majority of cases, hyperthermia is applied in one of two ways a high temperature for short time periods commonly referred to as ablation, or b lower temperatures for long time periods, often called mild hyperthermia. The former is used to kill cells directly with heat and consequently can be used to thermally ablate tumor. The second method is just above physiological temperature, and these temperatures are more often used to trigger release from thermosensitive drug carriers. "oth approaches can be combined with heat-sensitive drug targeting. There are many ways to induce nanoparticle mediated thermal therapy in solid tumors including absorption of infrared light, radiofrequency ablation and magnetically induced heating. These approaches have demonstrated high efficacy in preclinical models of HCC and are already tested in human clinical trials.Keywords: Nanoparticles, liver tumors, percutaneous ablation © 2015 The Author(s). Licensee InTech. This chapter is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. . IntroductionHepatocellular carcinoma HCC occurs predominantly in patients with chronic liver disease and limited hepatic functional reserve. Therefore, surgical removal of HCC is feasible only in % of cases and non-surgical modalities play a relatively important role in HCC management. There are several non-surgical methods however, ablation therapy has become a mainstay in particular for early-stage HCC because of its superb local control capabil...

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“…Imaging modalities, such as magnetic resonance imaging (MRI), ultrasound imaging, and X‐ray computed tomography (CT), are known as the most commonly used technologies in clinic to diagnose the tumor spatial location/size, track the drug's biodistribution, and monitor the therapeutic efficacy . In particular, MRI, which is based on nuclear magnetic resonance effect, offers multiple superiorities, such as high spatial and temporal resolution, unlimited tissue depth penetration, and exquisite soft‐tissue imaging with 3D anatomical details . However, conventional MRI alone cannot provide comprehensive diagnosis due to its inherent limitations, such as expensive costs, long scanning time, interference from image artifacts, and insensitivity to calcification, calculi, and bone cortex.…”

Section: Introductionmentioning

confidence: 99%

Cobalt Phosphide Nanoparticles Applied as a Theranostic Agent for Multimodal Imaging and Anticancer Photothermal Therapy

Liu

et al. 2018

Part & Part Syst Charact

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Biocompatible single‐component theranostic nanoagents instinctly affording multiple imaging modalities with satisfying therapeutic functions are highly desirable for anticancer treatments. Although cobalt‐based phosphides are well‐recognized as competent electrocatalysts, their potentials for biomedical applications remain unexplored. In this work, cobalt phosphide nanoparticles (CoP NPs) are developed to be a powerful theranostic agent for multimodal imaging and anticancer photothermal therapy. The uniform CoP NPs in a size of ≈21 nm are synthesized via a facile thermal decomposition method, followed by surface modification. The resultant CoP NPs exhibit excellent compatibility and stability in water as well as various physiological solutions. Supported by the good biocompatibility, strong near‐infrared absorption, and high photothermal conversion property, significant photothermal effect of the NPs is demonstrated, realizing efficient hyperthermia ablation on cancer cells. Importantly, the CoP NPs have shown considerable capabilities on high‐contrast in vitro and in vivo triple‐modal imaging, including infrared thermal (IRT), photoacoustic (PA), and T2‐weighted magnetic resonance (MR) imaging. This work has unraveled the promising potentials of CoP‐based nanoagent for precise diagnosis and efficient therapy.

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Glypican-3 antibody functionalized Prussian blue nanoparticles for targeted MR imaging and photothermal therapy of hepatocellular carcinoma

Abstract: MRI-guided photothermal therapy is becoming a more widely accepted minimally invasive technique.

Cited by 73 publications

References 42 publications

Inorganic nanoparticles for biomedicine: where materials scientists meet medical research

Inorganic nanoparticles for biomedicine: where materials scientists meet medical research

Old versus New – Tumor Ablation versus Tumor Nanoablation with Particular Emphasis on Liver Tumors

Cobalt Phosphide Nanoparticles Applied as a Theranostic Agent for Multimodal Imaging and Anticancer Photothermal Therapy

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