Glyphosate-based herbicide induces toxic effects on human adipose-derived mesenchymal stem cells grown in human plasma

Re-registration Challenges of Glyphosate in the European Union

“…In addition, Glifosato Atanor R was found genotoxic, correlated with lipid peroxidation and DNA fragmentation effects, at concentrations of 9-26% (corresponding to glyphosate concentrations of 0.038-0.113 mg/ml) on human peripheral blood leukocyte cells (Barbosa et al, 2017). Roundup Original R was found cytotoxic to human adipose-derived mesenchymal stem cells with an IC 50 value corresponding to glyphosate concentration of 43.0 ± 1.7 µg/ml, induced death by apoptosis and necrosis upon 24 h of exposure, and caused reduced alkaline phosphatase activity in cells induced to osteogenic differentiation (de Melo et al, 2018). Formulations containing glyphosate IPA salt, Roundup 3 Plus R , Roundup Biovert R , Amega R , Cargly R and Cosmic R , unlike glyphosate alone, were shown to affect cell proliferation in embryonic cells 360 min upon fertilization of the sea urchin Sphaerechinus granularis inducing a delay in entry into the Mphase in the cell cycle (Marc et al, 2002(Marc et al, , 2004.…”

Examining German Media Coverage of the Re-Evaluation of Glyphosate

“…Glyphosate was initially considered an effective and yet environmentally friendly herbicide [15] with relatively little ecological and toxicological side effects [16]. However, a review [17] highlights numerous studies that demonstrate negative effects of glyphosate on organisms, unicellular [18] and multicellular [19], invertebrates [20], and vertebrates [21,22]. While the active ingredient adheres to soil particles, its metabolite aminophosphonic acid (AMPA) is more mobile [6].…”