Glyoxal-induced exacerbation of pruritus and dermatitis is associated with staphylococcus aureus colonization in the skin of a rat model of atopic dermatitis

Han, Rafael Taeho; Kim, Hye Young; Ryu, Hyun Jin; Jang, Wooyoung; Ha, Su Min; Kim, Hyo Young; Lee, Jae Hee; Back, Seung Keun; Kim, Hee Jin; Na, Heung Sik

doi:10.1016/j.jdermsci.2018.02.012

Cited by 13 publications

(26 citation statements)

References 54 publications

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“…Exposure to 40% glyoxal vapour for 2 h daily over 5 weeks led to increased pruritus and dermatitis in rats with existing AD but did not induce AD symptoms in healthy animals, indicating that intrinsic barrier disruption is required for PM to exacerbate AD. Increased skin S. aureus colonization was observed in both AD and healthy animals after glyoxal exposure . Staphylococcus aureus is more prevalent on AD skin than on healthy skin, and colonization is a major driving factor in the disease cycle.…”

Section: Resultsmentioning

confidence: 97%

“…Non‐English‐language publications, review articles and case reports were excluded. Following these inclusion and exclusion criteria, a total of 21 publications were selected for evaluation in this review …”

Section: Methodsmentioning

confidence: 99%

“…16 Han et al used a rat model of capsaicin-induced AD to study the effects of vaporized glyoxal, a major source of PM production. Exposure to 40% glyoxal vapour for 2 h daily over 5 weeks led to increased pruritus and dermatitis in rats with existing AD but did not induce AD symptoms in healthy animals, 9 indicating that intrinsic barrier disruption is required for PM to exacerbate AD. Increased skin S. aureus colonization was observed in both AD and healthy animals after glyoxal exposure.…”

Section: Particulate Mattermentioning

confidence: 98%

“…Pollutants contribute to dysbiosis through bactericidal effects of O 3 that diminish commensal species, 20 as well as PM-induced increase in S. aureus colonization that contributes to AD flares. 9,39 The cascading and interrelated effects of oxidative damage, barrier defects, inflammation and dysbiosis pose a complex and multifaceted threat to skin homeostasis, with an exaggerated impact in the inherently barrier-impaired state of AD. The cutaneous effects of airborne pollution on the skin barrier may be viewed as analogous to the classic itch-scratch cycle of AD, wherein barrier disruption leads to irritation that promotes scratching, which further damages the skin barrier.…”

Section: Proposed Mechanism Of Pollution-induced Skin Barrier Dysfuncmentioning

confidence: 99%

“…Skin barrier dysfunction manifests as increased transepidermal water loss (TEWL), decreased stratum corneum hydration and increased stratum corneum pH . Barrier disruption facilitates the entry of environmental irritants, allergens and pathogens, inducing an inflammatory response . Resulting pruritus and excoriation further damage the barrier to fuel a vicious itch–scratch cycle .…”

Section: Types Of Pollutionmentioning

confidence: 99%

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The impact of airborne pollution on atopic dermatitis: a literature review

2020

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Summary The increasing prevalence of atopic dermatitis (AD) parallels a global rise in industrialization and urban living over recent decades. This shift in lifestyle is accompanied by greater cutaneous exposure to environmental pollutants during the course of daily activities. The objectives of this review are to highlight the effects of airborne pollution on epidermal barrier function, examine evidence on the relationship between pollutants and AD, synthesize a proposed mechanism for pollution‐induced exacerbation of AD, and identify potential methods for the reduction and prevention of pollutant‐induced skin damage. The literature review was done by searching the PubMed, Embase and Google Scholar databases. Inclusion criteria were in vitro and animal studies, clinical trials and case series. Non‐English‐language publications, review articles and case reports were excluded. Pollutants induce cutaneous oxidative stress and have been shown to damage skin barrier integrity by altering transepidermal water loss, inflammatory signalling, stratum corneum pH and the skin microbiome. AD represents a state of inherent barrier dysfunction, and both long‐ and short‐term pollutant exposure have been linked to exacerbation of AD symptoms and increased AD rates in population studies. Airborne pollutants have a detrimental effect on skin barrier integrity and AD symptoms, and appear to pose a multifaceted threat in AD through several parallel mechanisms, including oxidative damage, barrier dysfunction, immune stimulation and propagation of the itch–scratch cycle. Future research is needed to elucidate specific mechanisms of pollution‐induced epidermal barrier dysfunction and to identify efficacious methods of skin barrier repair and protection against pollutant‐driven damage.

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Section: Resultsmentioning

confidence: 97%

Section: Methodsmentioning

confidence: 99%