Glycyrrhizin protects spinal cord and reduces inflammation in spinal cord ischemia–reperfusion injury

Ni, Bin; Cao, Zhenyu; Liu, Yan

doi:10.3109/00207454.2013.796551

Cited by 30 publications

(16 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…GA was shown to inhibit HMGB1 production by Kupffer cells and prevented I/R-induced liver injury [40]. GA could also alleviate I/R-induced [41] and spinal cord [42] mechanism. In addition, GA conjugates free radicals, which might explain the protective action of GA [43].…”

Section: Inhibition Of Hepatic Apoptosis and Necrosismentioning

confidence: 96%

Glycyrrhizic Acid in the Treatment of Liver Diseases: Literature Review

Cao

Liu

et al. 2014

BioMed Research International

178

168

View full text Add to dashboard Cite

Glycyrrhizic acid (GA) is a triterpene glycoside found in the roots of licorice plants (Glycyrrhiza glabra). GA is the most important active ingredient in the licorice root, and possesses a wide range of pharmacological and biological activities. GA coupled with glycyrrhetinic acid and 18-beta-glycyrrhetic acid was developed in China or Japan as an anti-inflammatory, antiviral, and antiallergic drug for liver disease. This review summarizes the current biological activities of GA and its medical applications in liver diseases. The pharmacological actions of GA include inhibition of hepatic apoptosis and necrosis; anti-inflammatory and immune regulatory actions; antiviral effects; and antitumor effects. This paper will be a useful reference for physicians and biologists researching GA and will open the door to novel agents in drug discovery and development from Chinese herbs. With additional research, GA may be more widely used in the treatment of liver diseases or other conditions.

show abstract

Section: Inhibition Of Hepatic Apoptosis and Necrosismentioning

confidence: 96%

Glycyrrhizic Acid in the Treatment of Liver Diseases: Literature Review

Cao

Liu

et al. 2014

BioMed Research International

178

168

View full text Add to dashboard Cite

show abstract

“…Furthermore, glycyrrhizin has been reported to attenuate I/R-induced gut, spinal cord, liver and heart damage (9–14). However, to the best of our knowledge, the effect of glycyrrhizin on I/R-induced renal injury has not been investigated.…”

Section: Introductionmentioning

confidence: 99%

Glycyrrhizin protects mice against renal ischemia-reperfusion injury through inhibition of apoptosis and inflammation by downregulating p38 mitogen-activated protein kinase signaling

Zhu

Ming

et al. 2014

Experimental and Therapeutic Medicine

View full text Add to dashboard Cite

Ischemia-reperfusion (I/R) often leads to acute kidney injury, chronic renal failure and kidney transplantation failure. Glycyrrhizin is extracted from Glycyrrhiza glabra roots and is the predominant active component, which exhibits anti-inflammatory effects. However, to the best of our knowledge, the effect of glycyrrhizin on I/R-induced renal injury has not been investigated. In the present study, glycyrrhizin was demonstrated to attenuate renal I/R injury in mice via administration of glycyrrhizin, which suppressed the serum levels of creatinine and blood urea nitrogen 6 h following reperfusion; furthermore, the superoxide anions as well as the activity of superoxide dismutase within renal tissues was reduced by glycyrrhizin pretreatment. Moreover, the protein level of cleaved caspase-3, as well as its activity in renal tissue, was suppressed as a result of the glycyrrhizin pretreatment, indicating that glycyrrhizin inhibits I/R-induced renal cell apoptosis. In addition, glycyrrhizin pretreatment appeared to ameliorate I/R-induced renal injury via inhibition of inflammatory cell infiltration, as well as the production of pro-inflammatory cytokines, including tumor necrosis factor-α, interferon-γ, interleukin (IL)-1β and IL-6. The underlying molecular mechanism was investigated and it was shown that the activity of p38 mitogen-activated protein kinase signaling was downregulated as a result of glycyrrhizin administration. In conclusion, the present study indicated that glycyrrhizin provided significant protection against I/R-induced renal injury in mice by inhibiting inflammatory responses and renal cell apoptosis. Therefore, glycyrrhizin may be used in abdominal surgery and kidney transplantation for the prevention of renal I/R damage.

show abstract

“…Notably, the present study indicated that treatment with glycyrrhizin effectively decreased HMGB1 miRNA expression levels in rats with myocardial I/R injury. However, Ni et al (39) reported that the neuroprotective effect of glycyrrhizin prevents spinal cord I/R injury, through inflammatory cytokines and HMGB-1 expression.…”

Section: Discussionmentioning

confidence: 99%

Protective effect of glycyrrhizin on myocardial ischemia/reperfusion injury-induced oxidative stress, inducible nitric oxide synthase and inflammatory reactions through high-mobility group box 1 and mitogen-activated protein kinase expression

Cai

Wang

et al. 2017

Experimental and Therapeutic Medicine

View full text Add to dashboard Cite

Abstract. Glycyrrhizin, which is a type of perennial leguminous caudex, has been used in various Asian countries, including P.R. China, India and Japan, for thousands of years. The present study was designed to investigate the protective effect of glycyrrhizin on myocardial ischemia/reperfusion (I/R) injury through oxidative stress, inducible nitric oxide synthase (iNOS), and inflammatory reactions via high-mobility group box 1 (HMGB1) and mitogen-activated protein kinase (MAPK) expression. Sprague-Dawley rats were divided into five groups: Sham; myocardial I/R injury + non-treated; myocardial I/R injury + 2 mg/kg glycyrrhizin; myocardial I/R injury + 4 mg/kg glycyrrhizin; and myocardial I/R injury + 10 mg/kg glycyrrhizin. Pre-treatment with glycyrrhizin significantly reduced infarct size and inhibited creatine kinase, creatine kinase-MB, lactate dehydrogenase and cardiac troponin T activities in rats with myocardial I/R injury. Furthermore, glycyrrhizin treatment significantly suppressed oxidative stress, iNOS protein expression and inflammatory reactions in rats with myocardial I/R injury. Additionally, treatment with glycyrrhizin significantly decreased the release of HMGB1 from the cerebral cortex into the serum in rats with myocardial I/R injury. Notably, glycyrrhizin significantly suppressed p-ERK, p-p38 MAPK and p-c-Jun N-terminal kinase protein expressions, and promoted extracellular signal-regulated kinase protein expression in rats with myocardial I/R injury. Collectively, the present study indicates that the protective effect of glycyrrhizin may reduce myocardial I/R injury through oxidative stress, iNOS and inflammatory reactions, via HMGB1 and MAPK expression.

show abstract

Glycyrrhizin protects spinal cord and reduces inflammation in spinal cord ischemia–reperfusion injury

Cited by 30 publications

References 26 publications

Glycyrrhizic Acid in the Treatment of Liver Diseases: Literature Review

Glycyrrhizic Acid in the Treatment of Liver Diseases: Literature Review

Glycyrrhizin protects mice against renal ischemia-reperfusion injury through inhibition of apoptosis and inflammation by downregulating p38 mitogen-activated protein kinase signaling

Protective effect of glycyrrhizin on myocardial ischemia/reperfusion injury-induced oxidative stress, inducible nitric oxide synthase and inflammatory reactions through high-mobility group box 1 and mitogen-activated protein kinase expression

Contact Info

Product

Resources

About