Glycyrrhizin inhibits prostaglandin E2 production by activated peritoneal macrophages from rats

Ohuchi, Kazuo; Kamada, Yuko; Levine, Lawrence; Tsurufuji, Susumu

doi:10.1016/0161-4630(81)90033-1

Cited by 97 publications

(53 citation statements)

References 4 publications

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“…(Ohuchi et al, 1981). More than 95% of the adherent cells were found to engulf or attach to sheep red blood cells when examined 2 h after the incubation in the medium containing sheep red blood cells (Ohuchi et al, 1981 (Ohuchi et al, 1987a). At appropriate times of incubation, 100 pl of the medium was withdrawn and counted for the released radioactivity.…”

Section: Macrophage Culturementioning

confidence: 99%

Analysis of the stimulative effect of thapsigargin, a non‐TPA‐type tumour promoter, on arachidonic acid metabolism in rat peritoneal macrophages

Ohuchi

Sugawara

Watanabe

et al. 1988

British J Pharmacology

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1 At concentrations above IO ngml 1, the tumour promoter thapsigargin stimulates the release of radioactivity from [3H]-arachidonic acid-labelled macrophages harvested from rat peritoneal cavity. 2 The release of radioactivity from prelabelled macrophages was augmented more than additively when the cells were incubated in the medium containing both thapsigargin (10 ng ml-) and other tumour promoters (lOngml-1), such as 12-0-tetradecanoylphorbol-13-acetate (TPA), teleocidin and aplysiatoxin. 3 Thapsigargin required extracellular Ca2+ for the stimulation of arachidonic acid release, while TPA did not. 4 Cytoplasmic free calcium level was increased by thapsigargin treatment but not by TPA treatment.5 An inhibitor of protein kinases, H-7 inhibited the effect of TPA dose-dependently, whereas H-7 did not inhibit that of thapsigargin. 6 These results suggest that thapsigargin stimulates arachidonic acid release by a mechanism different from that of TPA, viz by acting as a selective Ca2+ mobilizer, but not by activating protein kinase C as TPA does.

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Section: Macrophage Culturementioning

confidence: 99%

Analysis of the stimulative effect of thapsigargin, a non‐TPA‐type tumour promoter, on arachidonic acid metabolism in rat peritoneal macrophages

Ohuchi

Sugawara

Watanabe

et al. 1988

British J Pharmacology

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“…32 Additionally, it has been shown to possess other pharmacological properties including anti-inflammatory, antiulcer, anti-allergic, immune-modulating and antiviral properties. [33][34][35][36] These actions combined may explain in part the positive results obtained for the production variables assessed in this study, as the productive parameters on week 18 showed a 14 % higher daily gain in the glycyrrhizic acid-treated group, 14 % higher feed consumption, and -0.4 % feed conversion than the control group (table 2). However, it is worth pointing out that the results obtained in this trial apply only to the commercial preparation utilized, i.e., Viusid-Vet® powder, as the effects of glycyrrhizic acid cannot be clearly separated from the combined antiox- Original Research idant and metabolic actions of all the components of the commercial preparation (glucosamine, maltodextrin, arginine, glycine, ascorbic acid, pyridoxal, folic acid, calcium pantothenate, cyanocobalamin, malic acid, zinc sulfate, potassium sorbate and sodium benzoate).…”

Section: Original Researchmentioning

confidence: 84%

Effects of glycyrrhizic acid (Viusid-Vet® powder) on the reduction of influenza virus spread and on production parameters in pigs

Ocampo-Camberos¹,

Tapia²,

Gutiérrez³

et al. 2017

Vet Méx OA

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Influenza viruses are among the most important respiratory pathogens in pigs and humans. They cause seasonal epidemics in pigs and occasional pandemics in humans. Herbal remedies have been regarded as suitable elements to aid in controlling influenza. This study was carried out to analyse the effects of the in-feed administration of glycyrrhizic acid, the best-known component of liquorice (as Viusid-Vet® powder), in pigs suffering an outbreak of influenza. Eighty crossbred Duroc-Landrace pigs, one day post-weaning (22 days old), were included in this trial. Piglets were randomly divided into the following two groups: those treated with glycyrrhizic acid and an untreated control group. Serological measurements to assess viral load and humoral responses were carried out. Blood samples from pigs were obtained every fortnight, starting on week two and ending on week 15. With these samples, haemagglutination inhibition (HI) tests were performed, using A/swine/New Jersey/11/76 (H1N1) and A/swine/Minnesota/9088-2/98 (H3N2) as reference viruses. Quantitative RT-PCR tests against the M gene of the influenza virus were also performed to assess viral shedding from nasal swab samples on weeks 1 to 8 after the beginning of the trial. Weight variables were assessed weekly for 18 weeks. In the HI tests, treated animals showed fewer positive responses compared to the control group for H1N1 and H3N2. However, a positive response to viral protection, as assessed by HI tests, was regarded as not conclusive of humoral immune stimulation. qRT-PCR tests for viral spread exhibited a lower rate of excretion for the treated group compared to the untreated one. Hence, it appears that glycyrrhizic acid stimulates, to some extent, immune responses against pig influenza as measured by viral shedding. For mean body weight, the generalized estimating equations show a higher weight gain for pigs treated with glycyrrhizic acid than the control group (P = 0.0001). These effects may assist producers in addressing the aftermath of an influenza outbreak.

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“…has been reported to possess various pharmacological activities such as anti-inflammation, 1) inhibition of prostaglandin E 2 (PGE 2 ) production in rat macrophages, 2) antiallergic, 3) antiviral 4,5) action, and interferon-g-induction. 6) In Japan, a glycyrrhizin preparation, Stronger-Neo Minophagen C (SNMC), has been used extensively for more than 30 years to treat chronic hepatitis.…”

Section: Glycyrrhizin (Gl) a Main Saponin Component Of Several Glycymentioning

confidence: 99%

Synthesis and Inhibitory Effect of Novel Glycyrrhetinic Acid Derivatives on IL-1.BETA.-Induced Prostaglandin E2 Production in Normal Human Dermal Fibroblasts

Tsukahara

Nishino

Furuhashi

et al. 2005

CHEMICAL & PHARMACEUTICAL BULLETIN

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Olean-11,13(18)-dien-3b b,30-diol dihemiphthalate (3), which was derived from glycyrrhetinic acid (GA), has been reported to produce a potent of anti-inflammatory effect in in vivo assays. Using 3 as a lead compound, we attempted to synthesize some modified compounds which varied in the following; i) the position of a carboxyl group in the phthalate moiety, ii) the number of carboxyls attached to the benzoyl group, iii) conversion of benzene ring to another ring system, iv) the linkage form between the benzene ring and oleanene skeleton at position 3 and/or 30. These were screened for their inhibitory activity against interleukin-1b b (IL-1b b )

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Glycyrrhizin inhibits prostaglandin E2 production by activated peritoneal macrophages from rats

Cited by 97 publications

References 4 publications

Analysis of the stimulative effect of thapsigargin, a non‐TPA‐type tumour promoter, on arachidonic acid metabolism in rat peritoneal macrophages

Analysis of the stimulative effect of thapsigargin, a non‐TPA‐type tumour promoter, on arachidonic acid metabolism in rat peritoneal macrophages

Effects of glycyrrhizic acid (Viusid-Vet® powder) on the reduction of influenza virus spread and on production parameters in pigs

Synthesis and Inhibitory Effect of Novel Glycyrrhetinic Acid Derivatives on IL-1.BETA.-Induced Prostaglandin E2 Production in Normal Human Dermal Fibroblasts

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